Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elizabeth X. Kwan"'
Autor:
Elizabeth X. Kwan, Gina M. Alvino, Kelsey L. Lynch, Paula F. Levan, Haley M. Amemiya, Xiaobin S. Wang, Sarah A. Johnson, Joseph C. Sanchez, Madison A. Miller, Mackenzie Croy, Seung-been Lee, Maria Naushab, Antonio Bedalov, Josh T. Cuperus, Bonita J. Brewer, Christine Queitsch, M.K. Raghuraman
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112161- (2023)
Summary: Timely completion of genome replication is a prerequisite for mitosis, genome integrity, and cell survival. A challenge to this timely completion comes from the need to replicate the hundreds of untranscribed copies of rDNA that organisms ma
Externí odkaz:
https://doaj.org/article/52aee668d64145149ab27041aab50554
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2829-2838 (2016)
The Saccharomyces cerevisiae ribosomal DNA (rDNA) locus is known to exhibit greater instability relative to the rest of the genome. However, wild-type cells preferentially maintain a stable number of rDNA copies, suggesting underlying genetic control
Externí odkaz:
https://doaj.org/article/cb66e24a57e74a2d88139da6632bfdb5
Autor:
Joseph C Sanchez, Elizabeth X Kwan, Thomas J Pohl, Haley M Amemiya, M K Raghuraman, Bonita J Brewer
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007041 (2017)
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins
Externí odkaz:
https://doaj.org/article/c428286c82bd4029ae1c65b1892d6f21
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263569 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263569 (2022)
We performed a comparative analysis of replication origin activation by genome-wide single-stranded DNA mapping in two common laboratory strains of Saccharomyces cerevisiae challenged by hydroxyurea (HU), an inhibitor of the ribonucleotide reductase.
Autor:
Calvin A. Mok, Christine Queitsch, Konstantin Queitsch, Vivek Nandakumar, Ashley N. Hall, Elizabeth A. Morton, Elizabeth X. Kwan, Bonita J. Brewer, John A. Stamatoyannopoulos, Robert H. Waterston
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 417-430 (2020)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Individuals within a species can exhibit vast variation in copy number of repetitive DNA elements. This variation may contribute to complex traits such as lifespan and disease, yet it is only infrequently considered in genotype-phenotype associations
Autor:
Maria Naushab, M. K. Raghuraman, Madison Miller, Seung-been Lee, Kelsey L. Lynch, Josh T. Cuperus, Xiaobin S. Wang, Joseph C. Sanchez, Bonita J. Brewer, Haley M. Amemiya, Paula F. Levan, Christine Queitsch, Mackenzie Croy, Elizabeth X. Kwan, Gina M. Alvino, Sarah A. Johnson
Eukaryotes maintain hundreds of copies of ribosomal DNA (rDNA), many more than required for ribosome biogenesis, suggesting a yet undefined role for large rDNA arrays outside of ribosomal RNA synthesis. We demonstrate that reducing the Saccharomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fd1fbef8a791125112761bb2c68fd00
https://doi.org/10.1101/2021.02.25.432950
https://doi.org/10.1101/2021.02.25.432950
Autor:
Elizabeth X Kwan, Eric J Foss, Scott Tsuchiyama, Gina M Alvino, Leonid Kruglyak, Matt Kaeberlein, M K Raghuraman, Bonita J Brewer, Brian K Kennedy, Antonio Bedalov
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003329 (2013)
Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a viney
Externí odkaz:
https://doaj.org/article/356236c712c8426c8604962fc9490be9
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 10, p e1008430 (2019)
PLoS Genetics, Vol 15, Iss 10, p e1008430 (2019)
Chromosome replication in Saccharomyces cerevisiae is initiated from ~300 origins that are regulated by DNA sequence and by the limited abundance of six trans-acting initiation proteins (Sld2, Sld3, Dpb11, Dbf4, Sld7 and Cdc45). We set out to determi
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002250 (2011)
Aging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard strain RM11 and a laboratory str
Externí odkaz:
https://doaj.org/article/b710e395a1c043d89ab80a28d9c63403
Autor:
Elizabeth X. Kwan, Joseph C. Sanchez, Maitreya J. Dunham, Mitsuhiro Tsuchiya, Christopher R. L. Large, Bonita J. Brewer, M. K. Raghuraman, Gina M. Alvino, Matt Kaeberlein, Matthew M. Crane, Courtnee Clough, Anja R Ollodart
The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, and thus, the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1202e7223254d0cac56e592dd0465603