Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elizabeth W. Kahney"'
Publikováno v:
EMBO reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914adc2f5c0dcb465da51a19a741a477
https://doi.org/10.15252/embr.202256404
https://doi.org/10.15252/embr.202256404
Stem cells have the unique ability to undergo asymmetric division which produces two daughter cells that are genetically identical, but commit to different cell fates. The loss of this balanced asymmetric outcome can lead to many diseases, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30409e8156bd6dbbb824a492571f6c0
https://doi.org/10.1101/2020.08.18.255455
https://doi.org/10.1101/2020.08.18.255455
Autor:
James Morris, Jennifer E. Golden, Elizabeth R. Sharlow, Elizabeth W. Kahney, Amber L. Hackler, Daniel P. Flaherty, Stephen L. Patrick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:755-758
A sulfonamidebenzamide series was assessed for anti-kinetoplastid parasite activity based on structural similarity to the antiparasitic drug, nifurtimox. Through structure-activity optimization, derivatives with limited mammalian cell toxicity and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9f314723faaac215cb2d5d40b3d0f5
https://doi.org/10.1016/j.bmcl.2017.01.043
https://doi.org/10.1016/j.bmcl.2017.01.043
Publikováno v:
Curr Opin Cell Biol
The asymmetric division of adult stem cells into one self-renewing stem cell and one differentiating cell is critical for maintaining homeostasis in many tissues. One paradigmatic model of this division is the Drosophila male and female germline stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65d07a523e0342dbfc6785566e10765
https://pubmed.ncbi.nlm.nih.gov/31014993
https://pubmed.ncbi.nlm.nih.gov/31014993
Autor:
Jeffrey Aubé, Elizabeth R. Sharlow, Amber L. Hackler, Stephen L. Patrick, Daniel P. Flaherty, Warren S. Weiner, Jennifer E. Golden, Haaris Khan, Michael T. Harris, James Morris, Chad E. Schroeder, Elizabeth W. Kahney
Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098b6d81bae60945cd1ef08213c0dd9f
https://europepmc.org/articles/PMC5808564/
https://europepmc.org/articles/PMC5808564/
Autor:
Andrew Maselli, Elizabeth W. Kahney, Michael T. Harris, April C. Joice, Heidi Dodson, James Morris, Daniel C. Whitehead
Publikováno v:
International Journal for Parasitology, Drugs and Drug Resistance
Graphical abstract
Highlights • Trypanosoma brucei hexokinase 1 is irreversibly inhibited by ebselen. • Mutation of Cys residues did not change hexamer abundance. • Active variants bearing Cys mutations were inhibited by ebselen. • ESI
Highlights • Trypanosoma brucei hexokinase 1 is irreversibly inhibited by ebselen. • Mutation of Cys residues did not change hexamer abundance. • Active variants bearing Cys mutations were inhibited by ebselen. • ESI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63776d6c0cc1fc57bc88feacc6b9cf6
https://pubmed.ncbi.nlm.nih.gov/24533305
https://pubmed.ncbi.nlm.nih.gov/24533305