Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Elizabeth W Tucker"'
Autor:
Xueyi Chen, Bhavatharini Arun, Oscar J. Nino-Meza, Mona O. Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth W. Tucker, Laurence S. Carroll, Joel S. Freundlich, Charles A. Peloquin, Vijay D. Ivaturi, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration. Here, we perform first
Externí odkaz:
https://doaj.org/article/12b747e27b024b34afbe5771b810380b
Autor:
John Kim, Ian Spears, Clara Erice, Hye-Young H. Kim, Ned A. Porter, Caitlin Tressler, Elizabeth W. Tucker
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106721- (2024)
Tuberculous (TB) meningitis is the deadliest form of extrapulmonary TB which disproportionately affects children and immunocompromised individuals. Studies in pulmonary TB have shown that Mycobacterium tuberculosis can alter host lipid metabolism to
Externí odkaz:
https://doaj.org/article/ddedd996dfea47ca90a8bdd08de80f30
Autor:
Filipa Mota, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Daniel P. Holt, Patricia De Jesus, Martin A. Lodge, Clara Erice, Xueyi Chen, Melissa Bahr, Kelly Flavahan, John Kim, Mary Katherine Brosnan, Alvaro A. Ordonez, Charles A. Peloquin, Robert F. Dannals, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the cent
Externí odkaz:
https://doaj.org/article/f0a782321c4e4e36aa37ab969660b2e2
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3f38821f6eaf47988003b3c7cf76c889
Autor:
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Maria I. Reyes-Mantilla, Clara Erice, Melissa Bahr, Kelly Flavahan, Patricia de Jesus, John Kim, Catherine A. Foss, Charles A. Peloquin, Dima A. Hammoud, Alvaro A. Ordonez, Carlos A. Pardo, Sanjay K. Jain
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the ba
Externí odkaz:
https://doaj.org/article/60a8e9fb510a41cda1c8b3797413d48b
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Central nervous system (CNS) infections occur more commonly in young children than in adults and pose unique challenges in the developing brain. This review builds on the distinct vulnerabilities in children's peripheral immune system (outlined in pa
Externí odkaz:
https://doaj.org/article/903070074762432da6de87daa9546f31
Autor:
Alvaro A. Ordonez, Matthew F.L. Parker, Robert J. Miller, Donika Plyku, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Justin M. Luu, Dustin A. Dikeman, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Lloyd S. Miller, Steven P. Rowe, David M. Wilson, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the
Externí odkaz:
https://doaj.org/article/5177739448e9442882f49a5d260f8ffe
Autor:
Oren Gordon, Mary Katherine Brosnan, Steve Yoon, Dawoon Jung, Kirsten Littlefield, Abhinaya Ganesan, Christopher A. Caputo, Maggie Li, William R. Morgenlander, Stephanie N. Henson, Alvaro A. Ordonez, Patricia De Jesus, Elizabeth W. Tucker, Nadine Peart Akindele, Zexu Ma, Jo Wilson, Camilo A. Ruiz-Bedoya, M. Elizabeth M. Younger, Evan M. Bloch, Shmuel Shoham, David Sullivan, Aaron A.R. Tobian, Kenneth R. Cooke, Ben Larman, Jogarao V.S. Gobburu, Arturo Casadevall, Andrew Pekosz, Howard M. Lederman, Sabra L. Klein, Sanjay K. Jain
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
BACKGROUND While most children who contract COVID-19 experience mild disease, high-risk children with underlying conditions may develop severe disease, requiring interventions. Kinetics of antibodies transferred via COVID-19 convalescent plasma early
Externí odkaz:
https://doaj.org/article/dd0c2a9ab4b14dc49bfbf39f9343ac3a
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
Central nervous system (CNS) infections remain a major burden of pediatric disease associated with significant long-term morbidity due to injury to the developing brain. Children are susceptible to various etiologies of CNS infection partly because o
Externí odkaz:
https://doaj.org/article/1141db979ae64785952ce114001be94d
Autor:
Jaime La Charite, Elizabeth W. Tucker, Julia Rosenberg, Janine Young, Nikita Gupta, Katherine Hoops
Publikováno v:
Laws, Vol 12, Iss 1, p 18 (2023)
Little is known of pediatric clinicians’ experiences with and approaches to taking care of immigrant children who have been in US custody. The objectives of this article are to (1) recognize the challenges facing pediatric clinicians in caring for
Externí odkaz:
https://doaj.org/article/57c209dd33934adc8172d5d4e75ee14f