Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth V. McDonnell"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122290 (2015)
Prostate cancer is the most frequent non-cutaneous malignancy in men. There is strong evidence in rodents that neonatal estrogen exposure plays a role in the development of this disease. However, there is little information regarding the effects of e
Externí odkaz:
https://doaj.org/article/c23b4462872542cc81d339e4a7b2f70a
Autor:
Kim Boekelheide, Michelle Vanlandingham, Sherry M. Lewis, Edward Dere, Susan J. Hall, Samantha J. Madnick, Daniel J. Spade, Linnea M. Anderson, Luísa Camacho, Susan M. Huse, Elizabeth V. McDonnell-Clark
Publikováno v:
Toxicology and Applied Pharmacology. 347:1-9
Bisphenol A (BPA) is a ubiquitous industrial chemical that has been identified as an endocrine disrupting compound (EDC). There is growing concern that early life exposures to EDCs, such as BPA, can adversely affect the male reproductive tract and fu
Publikováno v:
International Journal of Toxicology. 34:119-128
Prostate cancer is a common disease in older men. Rodent models have demonstrated that an early and later-life exposure to estrogen can lead to cancerous lesions and implicated hormonal dysregulation as an avenue for developing future prostate neopla
Autor:
Daniel J. Spade, Monique E. De Paepe, Kim Boekelheide, Philip A. Gruppuso, Jennifer A. Sanders, Elizabeth V. McDonnell, Camelia M. Saffarini, Nicholas E. Heger
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:410-422
Many diseases that manifest throughout the lifetime are influenced by factors affecting fetal development. Fetal exposure to xenobiotics, in particular, may influence the development of adult diseases. Established animal models provide systems for ch
Autor:
Kim Boekelheide, Camelia M. Saffarini, Daniel J. Spade, Elizabeth V. McDonnell, Susan M. Huse, Susan J. Hall
Publikováno v:
Toxicological Sciences. 138:148-160
In utero exposure to antiandrogenic xenobiotics such as di-n-butyl phthalate (DBP) has been linked to congenital defects of the male reproductive tract, including cryptorchidism and hypospadias, as well as later life effects such as testicular cancer
Autor:
Elizabeth V. McDonnell, Ali Amin, Camelia M. Saffarini, Daniel J. Spade, Susan J. Hall, Kim Boekelheide, Susan M. Huse, Stefan Kostadinov
Publikováno v:
The Prostate. 73:1761-1775
BACKGROUND Prostate cancer is the most commonly diagnosed nonskin cancer in men. The etiology of prostate cancer is unknown, although both animal and epidemiologic data suggest that early life exposures to various toxicants, may impact DNA methylatio
Autor:
Kamin J. Johnson, Kevin W. Gaido, Erin N. McDowell, Kayla A. Martin, Elizabeth V. McDonnell, Susan J. Hall, Moses A. Sandrof, Kim Boekelheide, Janan B. Hensley, Nicholas E. Heger
Publikováno v:
Environmental Health Perspectives
Background: In utero exposure to endocrine-disrupting chemicals may contribute to testicular dysgenesis syndrome (TDS), a proposed constellation of increasingly common male reproductive tract abnormalities (including hypospadias, cryptorchidism, hypo
Autor:
Nicholas E. Heger, Quanfu Mao, Christoph Schorl, Elizabeth V. McDonnell-Clark, Kim Boekelheide, Susan J. Hall, Monique E. De Paepe, Sharon Chu
Publikováno v:
Experimental lung research. 41(9)
Human fetal lung xenografts display an unusual pattern of non-sprouting, plexus-forming angiogenesis that is reminiscent of the dysmorphic angioarchitecture described in bronchopulmonary dysplasia (BPD). The aim of this study was to determine the cli
Autor:
David L. Martin, Anthony P. Russo, Donald H. Szarowski, Hisham Mohamed, Michele Caggana, James N. Turner, Elizabeth V. McDonnell, Michael G. Spencer, Lori A. Lepak
Publikováno v:
Journal of Chromatography A. 1111:214-219
In lab-on-a-chip applications, filtration is currently performed prior to sample loading or through pre-cast membranes adhered to the substrate. These membranes cannot be patterned to micrometer resolution, and their adhesion may be incompatible with
Autor:
Sarah N. Campion, Elizabeth V. McDonnell, Moses A. Sandrof, Camelia M. Saffarini, Kim Boekelheide, Sara E. Pacheco, Nicholas E. Heger, Natasha Catlin
Publikováno v:
Experientia Supplementum ISBN: 9783764383398
Mammalian reproductive tract development is a tightly regulated process that can be disrupted following exposure to drugs, toxicants, endocrine disrupting chemicals or other compounds via alterations to gene and protein expression or epigenetic regul