Výsledky vyhledávání - "Elizabeth V. Crabtree"

Akademický článek

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-l-xylitol (N-benzyl-l-XYLNAc)

Autor: Sarah. F. Jenkinson, Elizabeth. V. Crabtree, Andreas. F. G. Glawar, Terry D. Butters, George. W. J. Fleet, David. J. Watkin

Publikováno v: Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1147-o1148 (2010)

X-ray crystallography defines the relative configuration at the three-stereogenic centres in the title compound N-benzyl-l-XYLNAc, C14H20N2O3. The five-membered pyrrolidine ring adopts an envelope conformation with the N atom lying out of the plane o

Externí odkaz: https://doaj.org/article/a8384492d10549cbb8a87a8a6ca7f2b1

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Synthesis of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin [DGJNAc] from D-glucuronolactone: the first sub-micromolar inhibitor of alpha-N-acetylgalactosaminidases

Autor: Isao Adachi, Daniel Best, Atsushi Kato, Francis Xavier Wilson, Chu-Yi Yu, Phoom Chairatana, Elizabeth V. Crabtree, Wu-Bao Wang, George W. J. Fleet, Andreas F. G. Glawar, Yue-Mei Jia, Terry D. Butters

2-Acetamido-1,2-dideoxy- d -galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d -glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e017100adaaaccba35de40eb3d0d3eab
https://ora.ox.ac.uk/objects/uuid:f44a9088-286f-4768-9055-dd5c242f654e

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Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition

Autor: Daniel Best, Benjamin James Ayers, George W. J. Fleet, Atsushi Kato, Saori Miyauchi, Shinpei Nakagawa, José M. García Fernández, Matilde Aguilar-Moncayo, Elizabeth V. Crabtree, Francis Xavier Wilson, Carmen Ortiz Mellet, Andreas F. G. Glawar, Terry D. Butters

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The efficient scalable syntheses of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin (DGJNAc) and 2-acetamido-1,2-dideoxy-D-gluco-nojirimycin (DNJNAc) from D-glucuronolactone, as well as of their enantiomers from L-glucuronolactone, are reported. The ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd26b293f95ba5d17b9269e9c110dd9
https://pubmed.ncbi.nlm.nih.gov/22736508

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2-Acetamido-N-benzyl-1,4-imino-1,2,4-tride-oxy-l-xylitol (N-benzyl-l-XYLNAc)

Autor: Terry D. Butters, Sarah F. Jenkinson, George W. J. Fleet, David J. Watkin, Elizabeth V. Crabtree, Andreas F. G. Glawar

Publikováno v: Acta Crystallographica Section E, Vol 66, Iss 5, Pp o1147-o1148 (2010)
Acta Crystallographica Section E: Structure Reports

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db9822d82ad14f16e6ed53fb1c927da
http://ora.ox.ac.uk/objects/uuid:8fa757d4-cf26-4a8d-ae76-44f8da7afe01

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Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols

Autor: Isao Adachi, R. Fernando Martínez, Shinpei Nakagawa, Elizabeth V. Crabtree, Atsushi Kato, Terry D. Butters, Andreas F. G. Glawar, George W. J. Fleet

Publikováno v: Organic & Biomolecular Chemistry. 12:3932

The enantiomers of XYLNAc (2-N-acetylamino-1,2,4-trideoxy-1,4-iminoxylitol) are prepared from the enantiomers of glucuronolactone; the synthesis of the enantiomers of LYXNAc (2-N-acetylamino-1,2,4-trideoxy-1,4-iminolyxitol) from an L-arabinono-δ-lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e2dc944723eeb93113767b64250936
https://doi.org/10.1039/c4ob00097h

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Akademický článek

Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition.

Autor: Glawar, Andreas F. G.^1,2, Best, Daniel², Ayers, Benjamin J.², Miyauchi, Saori³, Nakagawa, Shinpei³, Aguilar-Moncayo, Matilde⁴, García Fernández, José M.⁵, Ortiz Mellet, Carmen⁴, Crabtree, Elizabeth V.^1,2, Butters, Terry D.¹, Wilson, Francis X.⁶, Kato, Atsushi³, Fleet, George W. J.^1,2

Publikováno v: Chemistry - A European Journal. Jul2012, Vol. 18 Issue 30, p9341-9359. 19p.

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Akademický článek

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Publikováno v: Organic & Biomolecular Chemistry; 2014, Vol. 12 Issue 23, p3759-3767, 9p

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Akademický článek

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols.

Autor: Crabtree, Elizabeth V., Martínez, R. Fernando, Nakagawa, Shinpei, Adachi, Isao, Butters, Terry D., Kato, Atsushi, Fleet, George W. J., Glawar, Andreas F. G.

Publikováno v: Organic & Biomolecular Chemistry; 2014, Vol. 12 Issue 23, p3932-3943, 12p

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