Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth Tringham"'
Autor:
Lina Chen, Hassan Pajouhesh, Cyrus Eduljee, Michael E. Hildebrand, Yongbao Zhu, Stephen P. Arneric, Molly Fee-Maki, Frank Porreca, Terrance P. Snutch, Paula L. Smith, Manjeet Parmar, Francesco Belardetti, Chris Bladen, David Parker, Clint J. Doering, Janette Mezeyova, Gerald W. Zamponi, Elizabeth Tringham, Jennifer Y. Xie
Publikováno v:
Pain. 152:833-843
Voltage-gated ion channels are implicated in pain sensation and transmission signaling mechanisms within both peripheral nociceptors and the spinal cord. Genetic knockdown and knockout experiments have shown that specific channel isoforms, including
Autor:
James B Herrington, Brande S. Williams, Vivien A. Warren, Rodolfo Haedo, Annie Liang, Cyrus Eduljee, D. Euan MacIntyre, Terrance P. Snutch, Clare London, Randal M. Bugianesi, Shruti Mistry, Owen B. McManus, Gregory J. Kaczorowski, Scott B. Hoyt, McHardy M. Smith, Catherine Abbadie, Kathryn A. Lyons, Elizabeth Tringham, Ge Dai, Joseph L. Duffy, Patricia B. Bunting, Andrew M. Swensen, Sylvia Volksdorf, Valerie V. White, Stephen P. Arneric, Shu-Yu Sun, Nina Jochnowitz, Erin McGowan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 334:545-555
Voltage-gated calcium channel (Ca(v))2.2 (N-type calcium channels) are key components in nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treating refractory pain but exhibit
Autor:
Diana Janke, Haiheng Dong, David Parker, Hassan Pajouhesh, Francesco Belardetti, Afsheen Khawaja, Stephen P. Arneric, Terrance P. Snutch, Cyrus Eduljee, Robert A. Fraser, Adam Hendricson, Elizabeth Tringham, Yoko Shimizu, Xinpo Jiang, Janette Mezeyova
Publikováno v:
ASSAY and Drug Development Technologies. 7:266-280
T-type voltage-gated Ca(2+) channels have been implicated in contributing to a broad variety of human disorders, including pain, epilepsy, sleep disturbances, cardiac arrhythmias, and certain types of cancer. However, potent and selective T-type Ca(2
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:806-814
The identification of currents carried by N- and P-type Ca(2+) channels in the nervous system relies on the use of omega-conotoxin (CTx) GVIA and omega-agatoxin (Aga) IVA. The peptide omega-Aga-IVA inhibits P-type currents at nanomolar concentrations
Publikováno v:
The Journal of Physiology. 578:693-714
To determine if the properties of Ca2+ channels in cerebellar Purkinje cells change during postnatal development, we recorded Ca2+ channel currents from Purkinje cells in cerebellar slices of mature (postnatal days (P) 40–50) and immature (P13–20
Autor:
Hassan Pajouhesh, Terrance P. Snutch, Elizabeth Tringham, Andrey Borzenko, Laurel L. Schafer, Jerrie-Lynn Morrison
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(11)
A novel approach to the synthesis of substituted piperazines and their investigation as N-type calcium channel blockers is presented. A common scaffold exhibiting high activity as N-type blockers is N-substituted piperazine. Using recently developed
Autor:
Manjeet Parmar, Kristy Kuplast, Gil S. Rind, Terrance P. Snutch, Janette Mezeyova, Emma L. Braine, David Parker, Xinpo Jiang, Nigel C. Jones, Terence J. O'Brien, Jerrie Lynn Morrison, Molly Fee-Maki, Stuart M. Cain, Manjula Weerapura, Elizabeth Tringham, Paula L. Smith, Hassan Pajouhesh, Cyrus Eduljee, Kim L. Powell
Publikováno v:
Science translational medicine. 4(121)
Absence seizures are a common seizure type in children with genetic generalized epilepsy and are characterized by a temporary loss of awareness, arrest of physical activity, and accompanying spike-and-wave discharges on an electroencephalogram. They
Autor:
Michael E. Hildebrand, Paula L. Smith, Terrance P. Snutch, Elizabeth Tringham, Michael W. Salter, Janette Mezeyova
Publikováno v:
Molecular Pain
Molecular Pain, Vol 7, Iss 1, p 67 (2011)
Molecular Pain, Vol 7, Iss 1, p 67 (2011)
Background: Voltage-gated sodium channels play key roles in acute and chronic pain processing. The molecular, biophysical, and pharmacological properties of sodium channel currents have been extensively studied for peripheral nociceptors while the pr
Autor:
Jerrie Lynn Morrison, Gerald W. Zamponi, Frank Porreca, Todd W. Vanderah, Elizabeth Tringham, Lester A. Mitscher, Eric Simonson, Terrance P. Snutch, Hossein Pajouhesh, Hassan Pajouhesh, Francesco Belardetti, Zhong Ping Feng, Lingyun Zhang, Yanbing Ding
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(4)
A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC(50) values in the ran
Autor:
Terrance P. Snutch, Elizabeth Tringham
Publikováno v:
Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels
Calcium (Ca2þ) is a ubiquitous signaling molecule involved in a diverse array of cellular processes ranging from control of membrane excitability to gene transcription, all of which require that intracellular levels be tightly regulated. In particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671b0d30b39947bf512c92dc4e3451c1
https://doi.org/10.1002/9780470429907.ch2
https://doi.org/10.1002/9780470429907.ch2