Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Elizabeth Terry-Kantor"'
Autor:
Elizabeth Terry-Kantor, Arati Tripathi, Thibaut Imberdis, Zachary M. LaVoie, Gary P. H. Ho, Dennis Selkoe, Saranna Fanning, Nagendran Ramalingam, Ulf Dettmer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5193 (2020)
Genetic and biochemical evidence attributes neuronal loss in Parkinson’s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein α-synuclein (αS). There is no consensus on how αS exerts toxicity. Explanations range from d
Externí odkaz:
https://doaj.org/article/96f85b570ea5491d9d3c2b51f3a6b6a6
Autor:
Arati Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer
Publikováno v:
J Neurosci
α-Synuclein (αS) plays a key role in Parkinson's disease. Although Parkinson's disease is typically “sporadic,” inherited αS missense mutations provide crucial insights into molecular mechanisms. Here, we examine two clinical mutants, E46K and
Autor:
Tracy L. Young-Pearse, Ulf Dettmer, Thibaut Imberdis, Elizabeth Terry-Kantor, Dennis J. Selkoe, Oren A. Levy, Tae-Eun Kim, Saranna Fanning, Gary P.H. Ho, Georgia L. Stirtz, Joseph Negri, Nagendran Ramalingam
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Misfolding and accumulation of the protein α-synuclein (αS) inside nerve cells characterize Parkinson’s disease (PD) and related brain diseases, for which no disease-modifying therapies exist. Robust cell models are needed that recap
Autor:
Thibaut Imberdis, Frank Soldner, Michel Becuwe, Sepp D. Kohlwein, Yelena Freyzon, Gary P.H. Ho, Aftabul Haque, Tobias C. Walther, Clary B. Clish, Elizabeth Terry-Kantor, Dennis J. Selkoe, Saranna Fanning, Gregory A. Newby, Daniel Termine, Tallie Noble, Nagendran Ramalingam, M. Inmaculada Barrasa, Robert V. Farese, Michael A. Welte, Susan Lindquist, Yali Lou, Jackson Sandoe, Tae-Eun Kim, Harald F. Hofbauer, Silke Nuber, David Pincus, Dirk Landgraf, Rudolf Jaenisch, Supriya Srinivasan, Ulf Dettmer, Valeriya Baru
Publikováno v:
PMC
In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995be04b05c6e841478eda306d3ad6bc
https://hdl.handle.net/1721.1/125128
https://hdl.handle.net/1721.1/125128
Autor:
Tim Bartels, Silke Nuber, Victoria E. von Saucken, Nagendran Ramalingam, Dennis J. Selkoe, Elizabeth Terry-Kantor, Ulf Dettmer, Maria Ericsson, Tae-Eun Kim, Andrew J. Newman, Saranna Fanning, Oren A. Levy, Susan Lindquist
α-Synuclein (αS) forms round cytoplasmic inclusions in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Evidence suggests a physiological function of αS in vesicle trafficking and release. In contrast to earlier tenets, recent work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb70667481e275a264a8ca7865e5a6f8
https://europepmc.org/articles/PMC5884392/
https://europepmc.org/articles/PMC5884392/