Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elizabeth T. Eng"'
Autor:
Nameer B. Kirma, Rajeshwar Rao Tekmal, Usha Mandava, Elizabeth T. Eng, D. Williams, Shiuan Chen
Publikováno v:
Annals of the New York Academy of Sciences. 963:239-246
Estrogen synthesized in situ plays a more important role in breast cancer cell proliferation than does circulating estrogen. Aromatase is the enzyme that converts androgen to estrogen and is expressed at a higher level in breast cancer tissue than in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e4ec55b0dc7806b690977278d24019
https://doi.org/10.1111/j.1749-6632.2002.tb04116.x
https://doi.org/10.1111/j.1749-6632.2002.tb04116.x
Publikováno v:
Pharmaceutical Biology. 36:53-61
Aromatase (CYP19) converts androgens to estrogens. By synthesizing estrogens, aromatase (especially tumor aromatase) is thought to play an important role in promoting breast cancer growth in postmenopausal women. By inhibiting estrogen biosynthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ade9b98fb77390b2be321cf8476f772
https://doi.org/10.1076/phbi.36.6.53.4555
https://doi.org/10.1076/phbi.36.6.53.4555
Autor:
Elizabeth T, Eng, JingJing, Ye, Dudley, Williams, Sheryl, Phung, Roger E, Moore, Mary K, Young, Ugis, Gruntmanis, Glenn, Braunstein, Shiuan, Chen
Publikováno v:
Cancer research. 63(23)
In breast cancer, in situ estrogen production has been demonstrated to play a major role in promoting tumor growth. Aromatase is the enzyme responsible for the conversion of androgen substrates into estrogens. This enzyme is highly expressed in breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb040d90cbf1ec4a339b09cc86f41bc7
https://pubmed.ncbi.nlm.nih.gov/14679019
https://pubmed.ncbi.nlm.nih.gov/14679019
Autor:
Fangming Zhang, Mark A. Sherman, Yoshio Osawa, Ikuko Kijima, Michael Cho, Dujin Zhou, Yate-Ching Yuan, Elizabeth T. Eng, Yoshiro Toma, Shiuan Chen
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 86(3-5)
The utilization of computer modeling, site-directed mutagenesis, inhibition kinetic analysis and reaction metabolite analysis allows us to better understand the structure-function relationship between aromatase and its inhibitors. Our results have he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7b339f8c7deca0bdbca699de814024
https://pubmed.ncbi.nlm.nih.gov/14623516
https://pubmed.ncbi.nlm.nih.gov/14623516
Autor:
Yeh-Chih Kao, Bin Yu, Chun Yang, Annette Kwon, Shiuan Chen, Tomoharu Okubo, Dujin Zhou, Elizabeth T. Eng, Baiba Grube
Publikováno v:
Annals of the New York Academy of Sciences. 963
Estrogen promotes the proliferation of breast cancer cells. Aromatase is the enzyme that converts androgen to estrogen. In tumors, expression of aromatase is upregulated compared to that of surrounding noncancerous tissue. Tumor aromatase is thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bac1bdc9499f116dea268d9ea71ab1
https://pubmed.ncbi.nlm.nih.gov/12095949
https://pubmed.ncbi.nlm.nih.gov/12095949
Autor:
Usha Mandava, Rajeshwar Rao Tekmal, Dudley Williams, Shiuan Chen, Elizabeth T. Eng, Nimeer Kirma
Publikováno v:
Breast cancer research and treatment. 67(2)
Estrogen promotes the proliferation of breast cancer cells. Aromatase is the enzyme that converts androgen to estrogen. In tumors, the expression of aromatase is upregulated compared to surrounding non-cancerous tissue. In this study, we found that w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a61d8990a0683e4b0df1f5a3c65645
https://pubmed.ncbi.nlm.nih.gov/11519862
https://pubmed.ncbi.nlm.nih.gov/11519862
Publikováno v:
Archives of biochemistry and biophysics. 385(1)
The rat form of DT-diaphorase (NAD(P)H: quinone acceptor oxidoreductase; EC 1.6.99.2) is more effective than the human form in activating prodrugs such as CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). Our site-directed mutagenesis study has revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea89e885dfd4b10fccb54f2bfdea8417
https://pubmed.ncbi.nlm.nih.gov/11361019
https://pubmed.ncbi.nlm.nih.gov/11361019