Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Elizabeth T. Ener"'
Autor:
Darko Bosnakovski, Erik A. Toso, Elizabeth T. Ener, Micah D. Gearhart, Lulu Yin, Felipe F. Lüttmann, Alessandro Magli, Ke Shi, Johnny Kim, Hideki Aihara, Michael Kyba
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107823- (2023)
Summary: Double homeobox (DUX) genes are unique to eutherian mammals, expressed transiently during zygotic genome activation (ZGA) and involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer when misexpressed. We evaluate the 3 human DUX
Externí odkaz:
https://doaj.org/article/a7c6f6cbfc28497fb285fd280369e1cd
Autor:
Darko Bosnakovski, Elizabeth T. Ener, Mark S. Cooper, Micah D. Gearhart, Kevin A. Knights, Natalie C. Xu, Christian A. Palumbo, Erik A. Toso, Graham P. Marsh, Hannah J. Maple, Michael Kyba
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-11 (2021)
Abstract CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the C-terminal transcriptional ac
Externí odkaz:
https://doaj.org/article/9014b9e9949c4001a62f7611aa341766
Autor:
Darko Bosnakovski, David Oyler, Ana Mitanoska, Madison Douglas, Elizabeth T. Ener, Ahmed S. Shams, Michael Kyba
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 1983 (2022)
FSHD is caused by loss of silencing of the DUX4 gene, but the DUX4 protein has not yet been directly detected immunohistologically in affected muscle, raising the possibility that DUX4 expression may occur at time points prior to obtaining adult biop
Externí odkaz:
https://doaj.org/article/6004c77f508143bc95c5736325e346bd
Autor:
Michael Kyba, Christian A Palumbo, Kevin A Knights, Micah D. Gearhart, Darko Bosnakovski, Hannah J. Maple, Erik A. Toso, Natalie C Xu, Mark S Cooper, Graham P. Marsh, Elizabeth T. Ener
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-11 (2021)
Oncogenesis
Oncogenesis
CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the transcriptional repressor Capicua (CIC) fused to the C-terminal transcriptional activation
Autor:
Ce Yuan, Ajit Jadhav, Darko Bosnakovski, Michael A. Walters, Erik A. Toso, Elizabeth T. Ener, Sithara T. Sunny, Meiricris T. Silva, Michael Kyba, Ziyou Cui
Publikováno v:
Science Advances
DUX4 drives global histone H3 hyperacetylation; and a new P300 inhibitor, iP300w, blocks DUX4-mediated transcription and toxicity.
Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription f
Facioscapulohumeral muscular dystrophy (FSHD) results from mutations causing overexpression of the transcription f