Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Elizabeth Strobert"'
Autor:
Elizabeth Strobert, Laura B. Higginbotham, Alfred Joseph Tector, Joseph M. Ladowski, Andrew B. Adams, Eric M. Walters, David V. Mathews, Alton B. Farris, Joe B. Jenkins, Gregory Martens, Cynthia P. Breeden, Christian P. Larsen, Allison Stephenson, Matthew Tector, Steven C. Kim
Publikováno v:
Am J Transplant
The shortage of available organs remains the greatest barrier to expanding access to transplantation. Despite advances in genetic editing and immunosuppression, survival in experimental models of kidney xenotransplantation has generally been limited
Autor:
W. C. Wakwe, Cynthia A. Breeden, Michael C. Lowe, Andrew B. Adams, Alton B. Farris, Mandy L. Ford, Robert M. Townsend, Mustimbo Roberts, David V. Mathews, Joe B. Jenkins, Christian P. Larsen, Steven C. Kim, Elizabeth Strobert
Publikováno v:
American Journal of Transplantation. 17:2285-2299
Recently, newer therapies have been designed to more specifically target rejection in an effort to improve efficacy and limit unwanted toxicity. Belatacept, a CD28-CD80/86 specific reagent, is associated with superior patient survival and graft funct
Autor:
Douglas J. Anderson, Elizabeth Strobert, Joe B. Jenkins, Denise J. Lo, Mingqing Song, Francis Leopardi, Allan D. Kirk, Christian P. Larsen
Publikováno v:
Clin Transplant
Belatacept, the CD28-B7 costimulation pathway inhibitor, has been approved as a calcineurin inhibitor (CNI) alternative in kidney transplantation. Although costimulation blockade (CoB) allows for CNI avoidance, it is associated with increased rates o
Autor:
Adriana E. Kajon, James E. Gern, Sujin Lee, Xiaoyan Lu, Martin L. Moore, Elizabeth Strobert, Yury A. Bochkov, Paul Spearman, Krishnendu Roy, Joe B. Jenkins, Ranjna Madan-Lala, Dean D. Erdman, Minh Trang Nguyen, Michael G. Currier
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
Nature Communications
Nature Communications
As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease. Early studies showed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing antib
Autor:
Allan D. Kirk, Francis Leopardi, Keith A. Reimann, Christian P. Larsen, Denise J. Lo, Joe B. Jenkins, Nicole A. Turgeon, Mingqing Song, Rijian Wang, Douglas J. Anderson, Elizabeth Strobert
Publikováno v:
American Journal of Transplantation. 16:1456-1464
Costimulation blockade with the fusion protein belatacept provides a desirable side effect profile and improvement in renal function compared with calcineurin inhibition in renal transplantation. This comes at the cost of increased rates of early acu
Autor:
Michael J. Ricciardi, Diogo M. Magnani, Cassia G. T. Silveira, Sherrie Jean, David E. Lee, Dennis R. Burton, Elizabeth Strobert, Lucas Gonzalez-Nieto, Nathan D. Grubaugh, Aline Domingues, Myrna C. Bonaldo, Guido Silvestri, Varian K. Bailey, Devin Sok, Khoa Le, Esper G. Kallas, Bryan Briney, Ann Chahroudi, Thomas H. Vanderford, Nathan Beutler, David I. Watkins, Thomas F. Rogers, Nuria Pedreño-Lopez, Erica E. Okwuazi, Stephen S. Whitehead, Mauricio A. Martins, Martin J. Gutman, Alexander Strubel, Helen S. Maxwell, Ronald C. Desrosiers
Publikováno v:
Science Translational Medicine. 9
Therapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasmablasts of a ZIKV-infected pa
Autor:
Bradley H. Collins, J. Cano, Michael C. Lowe, Joe B. Jenkins, Peter W. Thompson, Benjamin M. Martin, Kannan P. Samy, C.R. Dove, F. Leopardi, Elizabeth Strobert, Alton B. Farris, M. Song, Christian P. Larsen, Allan D. Kirk
Publikováno v:
American Journal of Transplantation. 15:1241-1252
Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet loss remains substantial and attributed to an instant blood mediated inflammatory reaction
Autor:
M. Song, Steven J. Chapin, Denise Lo, Frank V. Leopardi, Allan D. Kirk, Erik E. Karrer, Bruce H. Devens, Elizabeth Strobert, Douglas J. Anderson, Alton B. Farris
Publikováno v:
American Journal of Transplantation. 15:984-992
Costimulation blockade with the B7-CD28 pathway-specific agent belatacept is now used in clinical kidney transplantation, but its efficacy remains imperfect. Numerous alternate costimulatory pathways have been proposed as targets to synergize with be
Autor:
Maria E. Fuentes, Ying Dong, Christian P. Larsen, Cynthia P. Breeden, William H. Kitchens, Elizabeth Strobert, David V. Mathews, Mandy L. Ford, Andrew B. Adams
Publikováno v:
JCI Insight. 2
The potential of costimulation blockade to serve as a novel transplant immunosuppression strategy has been explored for over 20 years, culminating in the recent clinical approval of belatacept for renal transplant patients. Despite improving long-ter
Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection
Autor:
Christian P. Larsen, Anish Suri, Elizabeth Strobert, Aaron P. Yamniuk, Steven G. Nadler, Steven C. Kim, Thomas C. Pearson, Walter Wakwe, Cynthia P. Breeden, Robert Kuhn, Andrew B. Adams, Mandy L. Ford, Haiqing Wang, Joe B. Jenkins, Allison Stephenson, David V. Mathews, Karen Price, Suzanne J. Suchard, Laura B. Higginbotham, Alton B. Farris, Laura Price
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(5)
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD1