Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth Skuba"'
Publikováno v:
Toxicologic Pathology. 45:223-237
The continuing education course on integrating clinical and anatomical pathology data was designed to communicate the importance of using a weight of evidence approach to interpret safety findings in toxicology studies. This approach is necessary, as
Autor:
Diane E. Gunson, Phil Bentley, Michael Hayes, Elizabeth Skuba, Peter Hoffmann, Dan Lapadula, Steve Busch, Lori Martin, Michael Keselica
Publikováno v:
Toxicologic Pathology. 45:76-83
This article describes acute toxicity data in cynomolgus monkeys following oral treatment with vildagliptin, a dipeptidyl peptidase-4 inhibitor. Acute toxicity symptoms in cynomolgus monkeys include edema formation of the extremities, tails, and face
Autor:
Terrilyn A. Richardson, Chi-Hse Teng, Audrey Fischer, Marianne Schwald, William Kluwe, Joerg Andreas Mahl, Robin Alec Fairhurst, Luigi Manenti, Francois Pognan, Armin Wolf, Gerd A. Kullak-Ublick, Mathilde Lienard, Jacqueline Kinyamu-Akunda, Elizabeth Skuba, Salah-Dine Chibout, Andreas Weiss, Kuno Wuersch, Philippe Couttet, Heiko Schadt, Diana Graus Porta, Corinne Emotte
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
The FGF19- fibroblast growth factor receptor (FGFR4)-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset
Autor:
Paul Vancutsem, Marc DeCristofaro, Salah-Dine Chibout, Armin Wolf, Tao Wang, M. Craig Keselica, Francois Pognan, Marion Wiesmann, Elizabeth Skuba, Maria Papoutsi, Judit Markovits, Robert H. Spaet, James Sutton, Pierre Moulin, William Kluwe, Lew Petryk
Publikováno v:
International Journal of Toxicology. 30:300-312
This article addresses the issue of miscorrelation between hepatic injury biomarkers and histopathological findings in the drug development context. Our studies indicate that the use of toxicogenomics can aid in the drug development decision-making p
Autor:
Janetta Dewhurst, Branko Radetich, Gerard Joberty, Lawrence G. Hamann, Erin P. Keaney, Kara Balabanis, Jian Shao, Keith Hoffmaster, Tommasi Ruben A, Ivan Cornella-Taracido, Tewis Bouwmeester, Michael Franti, Aurelio Bonavia, Bushell Simon, Leanne Lanieri, Teresa Compton, Mohindra Seepersaud, Jakal Amin, Michelle Broome, John A. Tallarico, Colin P. Osborne, Elizabeth Skuba, Judit Markovits, Ayako Honda, James Monroe, Karen Wolff, Kelli Kuhen
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6739-6744
The search for novel therapeutic interventions for viral disease is a challenging pursuit, hallmarked by the paucity of antiviral agents currently prescribed. Targeting of viral proteins has the inextricable challenge of rise of resistance. Safe and
Autor:
Joseph Cruz, Chikwendu Ibebunjo, Michelle Broome, Sophie Brachat, Sabine Gutzwiller, Steven P. Gygi, QiCheng Ma, Christine Li, John K. Eash, Brigitte Fournier, David J. Glass, Tracee L. Kendall, Brian A. Clarke, Yunyu Zhang, Joel M. Chick, Zhidan Wu, Elizabeth Skuba, Judit Markovits, Michelle Steinkrauss, Jun Shi, Jean-Rene Galarneau, Chad Vickers
Molecular mechanisms underlying sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear. To identify molecular changes that correlated best with sarcopenia and might contribute to its pathogenesis, we determined global g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b22769308ebbe381f2179855585dcd
https://europepmc.org/articles/PMC3554128/
https://europepmc.org/articles/PMC3554128/
Autor:
Michael C. Milone, Elizabeth Skuba, Daher Ibrahim Aibo, LeeAnne Talbot, Regina M. Young, Lori Martin, Vijay Bhoj, Steve Busch, Saar Gill, Jennifer Marlowe, Timothy K. MacLachlan, Linda Dong, Olga Shestova, Celeste Richardson, Xiaorui Yao
Publikováno v:
Molecular Therapy. 24:S158
The CAR-T platform has provided an exceptionally potent means to treat cancers that have proven resistant to standard treatments. This potency, however, can work against normal tissue as well. Some clinical trials have identified adverse consequences
Publikováno v:
Veterinary and Comparative Orthopaedics and Traumatology. :82-87
SummaryRectus femoris muscle slings were transposed over femoral head ostectomy sites in four large breed dogs, while in three other dogs, standard femoral head and neck excision arthroplasty was performed. After the operation two dogs, with rectus f
Publikováno v:
Toxicologic Pathology; Jan2017, Vol. 45 Issue 1, p52-56, 5p
Autor:
Hoffmann, Peter, Martin, Lori, Keselica, Michael, Gunson, Diane, Skuba, Elizabeth, Lapadula, Dan, Hayes, Michael, Bentley, Phil, Busch, Steve
Publikováno v:
Toxicologic Pathology; Jan2017, Vol. 45 Issue 1, p76-83, 8p