Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes

Autor: Hannah L Klein, Kenny K.H. Ang, Michelle R. Arkin, Emily C. Beckwitt, Yi-Hsuan Chang, Jun Fan, Youngho Kwon, Michael J. Morten, Sucheta Mukherjee, Oliver J. Pambos, Hafez el Sayyed, Elizabeth S. Thrall, João P. Vieira-da-Rocha, Quan Wang, Shuang Wang, Hsin-Yi Yeh, Julie S. Biteen, Peter Chi, Wolf-Dietrich Heyer, Achillefs N. Kapanidis, Joseph J. Loparo, Terence R. Strick, Patrick Sung, Bennett Van Houten, Hengyao Niu, Eli Rothenberg

Publikováno v: Microbial Cell, Vol 6, Iss 1, Pp 65-101 (2019)

Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. In vivo, many of such changes are studies using reporters for specific types of changes, or through cytological studies that detect changes at the single

Externí odkaz: https://doaj.org/article/284d1fa54b1b42a89ebab92b52616ba5

Compartmentalization of the replication fork by single-stranded DNA-binding protein regulates translesion synthesis

Autor: Seungwoo Chang, Elizabeth S. Thrall, Luisa Laureti, Sadie C. Piatt, Vincent Pagès, Joseph J. Loparo

Publikováno v: Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 2022, 29 (9), pp.932+. ⟨10.1038/s41594-022-00827-2⟩
Nat Struct Mol Biol

Processivity clamps tether DNA polymerases to DNA, allowing their access to the primer-template junction. In addition to DNA replication, DNA polymerases also participate in various genome maintenance activities, including translesion synthesis (TLS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a976ee7bf300c9759acd8812d70dfd9a
https://doi.org/10.1038/s41594-022-00827-2

Machine learning for functional group identification in vibrational spectroscopy: A pedagogical lab for undergraduate chemistry students

Autor: Joshua Schrier, Elizabeth S. Thrall, Seung Eun Lee, Yijun Shao

Techniques from the branch of artificial intelligence known as machine learning (ML) have been applied to a wide range of problems in chemistry. Nonetheless, there are very few examples of pedagogical activities to introduce ML to chemistry students

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e870f51a0f5abea94c5013e938afd2
https://doi.org/10.33774/chemrxiv-2021-db11k

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Autor: Seungwoo Chang, Elizabeth S. Thrall, Joseph J. Loparo, James E. Kath

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications

Unrepaired DNA lesions are a potent block to replication, leading to replication fork collapse, double-strand DNA breaks, and cell death. Error-prone polymerases overcome this blockade by synthesizing past DNA lesions in a process called translesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a2fcceadf1c12984968f8200a7da8a
http://link.springer.com/article/10.1038/s41467-017-02333-2

The Role of Photon Energy and Semiconductor Substrate in the Plasmon-Mediated Photooxidation of Citrate by Silver Nanoparticles

Autor: Asher Preska Steinberg, Louis E. Brus, Elizabeth S. Thrall, Xiaomu Wu

Publikováno v: The Journal of Physical Chemistry C. 117:26238-26247

The plasmon-mediated photooxidation of citrate ions adsorbed on silver (Ag) nanoparticle–semiconductor electrodes is studied in a photoelectrochemical cell. Consistent with previous reports, a negative photovoltage and an anodic photocurrent arise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4257f13ceac6e8f058ac116d3e44db1a
https://doi.org/10.1021/jp409586z