Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria

Autor: Christina D. Edgar, Elizabeth S. Poole, Johannes Fredebohm, Jennifer Murphy, Warren P. Tate, David J. Young

Publikováno v: RNA. 16:1146-1155

Vertebrate mitochondria use stop codons UAA and UAG decoded by the release factor (RF) MTRF1L and two reassigned arginine codons, AGA and AGG. A second highly conserved RF-like factor, MTRF1, which evolved from a gene duplication of an ancestral mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2a9bdfe99ce07aa6eafe8ad716cff1
https://doi.org/10.1261/rna.1970310

Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms

Autor: Alhad A. Mahagaonkar, Leif A. Isaksson, Elizabeth S. Poole, Louise L. Major, Warren P. Tate, Andrew G. Cridge

Publikováno v: Nucleic Acids Research

Six diverse prokaryotic and five eukaryotic genomes were compared to deduce whether the protein synthesis termination signal has common determinants within and across both kingdoms. Four of the six prokaryotic and all of the eukaryotic genomes invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0621f0ff9b0ca3fe50f4a3388f3d79a6
https://doi.org/10.1093/nar/gkl074

Risk of Ovarian Cancer and the NF-κB Pathway: Genetic association with IL1A and TNFSF10

Autor: Angela Brooks-Wilson, Ingo B. Runnebaum, Hannah P. Yang, Graham G. Giles, David N. Rider, Evelyn Despierre, Arto Leminen, Jennifer A. Doherty, Lene Lundvall, Alexander Hein, Roberta B. Ness, James Paul, Ralf Bützow, Piotr Sobiczewski, Leon F.A.G. Massuger, Urmila Chandran, Sara H. Olson, Cezary Cybulski, Galina Lurie, Pamela J. Thompson, Lynne R. Wilkens, Anne M. van Altena, Peter A. Fasching, Mari K. Halle, Hoda Anton-Culver, Valerie McGuire, Camilla Krakstad, Claus Høgdall, William R. Bamlet, Kimberly R. Kalli, Jan Lubinski, Matthew S. Block, Agnieszka Dansonka-Mieszkowska, Keith L. Knutson, Shan Wang-Gohrke, Britton Trabert, Jenny Lester, David Van Den Berg, Stanley B. Kaye, Natalia Bogdanova, Helga B. Salvesen, Arif B. Ekici, Gianluca Severi, Linda E. Kelemen, Alice S. Whittemore, Jonathan Tyrer, Kunle Odunsi, Montserrat Garcia-Closas, Zachary C. Fogarty, Elisa V. Bandera, Diana Eccles, Robert H Edwards, Honglin Song, Joellen M. Schildkraut, Paul D.P. Pharoah, Elisabeth Wik, Matthias W. Beckmann, Simon A. Gayther, Andrew Berchuck, Georgia Chenevix-Trench, Lambertus A. Kiemeney, Francesmary Modugno, Estrid Høgdall, Malcolm C. Pike, Linda S. Cook, Elizabeth S. Poole, Philipp Harter, Clareann H. Bunker, Lukasz Szafron, Harvey A. Risch, Sandrina Lambrechts, Christine S. Walsh, Joseph H. Rothstein, Yukie Bean, Ian Sean Campbell, James M. Flanagan, Heli Nevanlinna, Robert A. Vierkant, Anja Rudolph, Nhu D. Le, Diether Lambrechts, Ellen L. Goode, Julie M. Cunningham, Catherine M. Phelan, Jie Lin, Jacek Gronwald, Kirsten B. Moysich, Shelley S. Tworoger, Kathryn L. Terry, Allan Jensen, Ignace Vergote, Celeste Leigh Pearce, Ira Schwaab, Lara Sucheston, Katja K.H. Aben, Michelle A.T. Hildebrandt, Grace Friel, Susanne K. Kjaer, Laura Baglietto, Thomas A. Sellers, Susan J. Ramus, Irene Orlow, Jolanta Kupryjanczyk, Nicolas Wentzensen, Steven A. Narod, Karen H. Lu, Daniel W. Cramer, Argyrios Ziogas, Andreas du Bois, Aleksandra Gentry-Maharaj, Jenny Chang-Claude, Janusz Menkiszak, Robert M Brown, Louise A. Brinton, Marc T. Goodman, Liisa M. Pelttari, Tanja Pejovic, Bridget Charbonneau, Usha Menon, Florian Heitz, Beth Y. Karlan, Dong Liang, Brooke L. Fridley, Mary Anne Rossing, Thilo Dörk, Douglas A. Levine, Allison F. Vitonis, Anna H. Wu, Weiva Sieh

Publikováno v: Cancer Research, 74, 3, pp. 852-61
Cancer Research, 74, 852-61
Cancer Research

Contains fulltext : 136742.pdf (Publisher’s version ) (Closed access) A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246d782bb5f5b65de447039296e193c8
https://europepmc.org/articles/PMC3946482/

Selection of aminoacyl-tRNAs at sense codons: the size of the tRNA variable loop determines whether the immediate 3′ nucleotide to the codon has a context effect

Autor: Warren P. Tate, Elizabeth S. Poole, James F. Curran, Beverly L. Gross

Publikováno v: Nucleic Acids Research. 23:4104-4108

Codon context can affect translational efficiency by several molecular mechanisms. The base stacking interactions between a codon-anticodon complex and the neighboring nucleotide immediately 3' can facilitate translation by amber suppressors and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fdd4cb45b929106519c561afa08f0b
https://doi.org/10.1093/nar/23.20.4104

A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons

Autor: Elizabeth S. Poole, Warren P. Tate, Tony S. Cardno, Suneeth F. Mathew, Ryan Graves

Publikováno v: RNA

Recoding mechanisms are programmed protein synthesis events used commonly by viruses but only very rarely in cells for cellular gene expression. For example, HIV-1 has an absolute reliance on frameshifting to produce the correct ratio of key proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd897d9eaf45078084e68c0f263ce60
https://europepmc.org/articles/PMC2714747/