Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elizabeth S. McKenney"'
Publikováno v:
Frontiers in Microbiology, Vol 3 (2012)
The methylerythritol phosphate (MEP) pathway is essential in most prokaryotes and some lower eukaryotes but absent from human cells, and is a validated target for antimicrobial drug development. The formation of MEP is catalyzed by 1-deoxy-D-xylulose
Externí odkaz:
https://doaj.org/article/6b0569eb8017442084c7ea10f258cb9d
Autor:
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e38167 (2012)
Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The
Externí odkaz:
https://doaj.org/article/06a91359bad242128ad771b2c63ac854
Autor:
Gregory D. Cuny, Lizbeth Hedstrom, Yan Zhang, Helena I. Boshoff, Meaghan M. Rabideau, Hannah M. Bernstein, Suresh Kumar Gorla, Minjia Zhang, Corey R. Johnson, Ian J. Glomski, Shibin Chacko, Kavitha Mandapati, Elizabeth S. McKenney, Aiping Qin, Amanda L. House, Barbara J. Mann, Joanna B. Goldberg
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Francisella tularensis is the causative agent of tularemia and a potential biowarfare agent. The virulence of F. tularensis is decreased by deletion of guaB , the gene encoding IMP dehydrogenase (IMPDH), suggesting that this enzyme is a target for an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0744dac4c4473718d3b206fc7080c8
https://doi.org/10.1128/aac.00939-17
https://doi.org/10.1128/aac.00939-17
Autor:
Elizabeth S. McKenney, Suraj Nagendra Rao, Deviprasad R. Gollapalli, Ian J. Glomski, Lizbeth Hedstrom, Joanna B. Goldberg, Kavitha Mandapati, Amanda L. House, Gregory D. Cuny, Barbara J. Mann, Minjia Zhang, Suresh Kumar Gorla
Publikováno v:
ACS Medicinal Chemistry Letters. 5:846-850
Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8269b3bd144c8685b5f82b740b2bdcbb
https://doi.org/10.1021/ml500203p
https://doi.org/10.1021/ml500203p
Autor:
Joanna B. Goldberg, Herbert P. Schweizer, Elizabeth S. McKenney, Mariette Barbier, George W. Liechti, F. Heath Damron
Publikováno v:
Applied and Environmental Microbiology. 79:4149-4153
We describe the construction of mini-Tn 7 -based broad-host-range vectors encoding lux genes as bioluminescent reporters. These constructs can be mobilized into the desired host(s) by conjugation for chromosomal mini-Tn 7-lux integration and are usef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5376a58c5b4002058a3c759b1cf3829
https://doi.org/10.1128/aem.00640-13
https://doi.org/10.1128/aem.00640-13
Autor:
Elizabeth S. McKenney, Kavitha Mandapati, Suraj Nagendra Rao, Lizbeth Hedstrom, Joanna B. Goldberg, Barbara J. Mann, Gregory D. Cuny, Suresh Kumar Gorla, Minjia Zhang, Amanda L. House, Deviprasad R. Gollapalli, Ian J. Glomski
The structures of A98, P146, and P150 in the TOC Graphic and Figure 3b were incorrect. The Cl substituent should be in the 4 position, and the amide substituents should be in the 3 position as shown below. Regrettably, several structures were incorre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb28ffba4cce8cf24b311c20984a66e7
https://europepmc.org/articles/PMC4190637/
https://europepmc.org/articles/PMC4190637/
Autor:
Joanna B. Goldberg, Elizabeth S. McKenney, Michael J. Schurr, F. Heath Damron, Mariette Barbier
Publikováno v:
Journal of bacteriology. 195(18)
Pseudomonas aeruginosa is an opportunistic pathogen that can adapt to changing environments and can secrete an exopolysaccharide known as alginate as a protection response, resulting in a colony morphology and phenotype referred to as mucoid. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571980564ca116505f45090f22f990c
https://pubmed.ncbi.nlm.nih.gov/23794622
https://pubmed.ncbi.nlm.nih.gov/23794622
Microbiota and pathogen ‘pas de deux’: setting up and breaking down barriers to intestinal infection
Publikováno v:
Pathogens and Disease. 74:ftw051
The gut microbiota plays essential roles in human health and disease. In this review, we focus on the role of the intestinal microbiota in promoting resistance to infection by bacterial pathogens as well as how pathogens overcome this barrier. We dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648d0059db426e722586dd8ac108a9ca
https://doi.org/10.1093/femspd/ftw051
https://doi.org/10.1093/femspd/ftw051
Publikováno v:
Applied and environmental microbiology. 79(2)
We describe a mini-Tn 7 -based broad-host-range expression cassette for arabinose-inducible gene expression from the P BAD promoter. This delivery vector, pTJ1, can integrate a single copy of a gene into the chromosome of Gram-negative bacteria for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2018ac76639d2fa29896e43e7ae9345a
https://pubmed.ncbi.nlm.nih.gov/23124231
https://pubmed.ncbi.nlm.nih.gov/23124231
Autor:
McKenney, Elizabeth S.1, Sargent, Michelle2, Khan, Hameed3, Uh, Eugene2, Jackson, Emily R.2, San Jose, Géraldine2, Couch, Robin D.3,4, Dowd, Cynthia S.2, van Hoek, Monique L.1,4 mvanhoek@gmu.edu
Publikováno v:
PLoS ONE. Oct2012, Vol. 7 Issue 10, Special section p1-12. 12p.