Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elizabeth S. Childress"'
Autor:
Christopher C. Presley, Charles K. Perry, Elizabeth S. Childress, Matthew J. Mulder, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Externí odkaz:
https://doaj.org/article/5fdf499332094c6c9828c3faab3a798f
Autor:
Stefan R. Hargett, Elizabeth S. Childress, Joseph M. Salamoun, Jose A Santiago-Rivera, Divya P. Shah, Christopher J Garcia, Webster L. Santos, Sing-Young Chen, Kyle L. Hoehn, Stephanie J. Alexopoulos, Yumin Dai, Simon P. Tucker
Publikováno v:
J Med Chem
Small molecule mitochondrial uncouplers are emerging as a new class of molecules for the treatment of nonalcoholic steatohepatitis. We utilized BAM15, a potent protonophore that uncouples the mitochondria without depolarizing the plasma membrane, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c63066c5df1da3ac8c7de08a159b6e
https://doi.org/10.1021/acs.jmedchem.9b01440
https://doi.org/10.1021/acs.jmedchem.9b01440
Autor:
Colleen M. Niswender, Christopher C Presley, P. Jeffrey Conn, Vincent B. Luscombe, Alice L. Rodriguez, Charles K. Perry, Craig W. Lindsley, Matthew J. Mulder, Elizabeth S. Childress
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507940bc2a7cff2b1f11bcdaff15da0
https://doi.org/10.1021/acsomega.9b02017
https://doi.org/10.1021/acsomega.9b02017
Autor:
Sing-Young Chen, Simon P. Tucker, Stefan R. Hargett, Elizabeth S. Childress, Martina Beretta, Kyle L. Hoehn, Kate G. R. Quinlan, Stephanie J. Alexopoulos, Webster L. Santos, Isabella Aleksovska, Charles G. Cranfield, Divya P. Shah, Ellen M. Olzomer, Joseph M. Salamoun, Tristan Rawling, Ariane Roseblade, Margaret J. Morris
Publikováno v:
Metabolism: clinical and experimental. 117
Aims Mitochondrial uncouplers decrease caloric efficiency and have potential therapeutic benefits for the treatment of obesity and related metabolic disorders. Herein we investigate the metabolic and physiologic effects of a recently identified small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19db1b6d2ea6e699712033db27bda54
https://pubmed.ncbi.nlm.nih.gov/33548253
https://pubmed.ncbi.nlm.nih.gov/33548253
Autor:
Colleen M. Niswender, Craig W. Lindsley, Andrew S. Felts, Vincent B. Luscombe, P. Jeffrey Conn, Hyekyung P. Cho, Elizabeth S. Childress, Megan M. Breiner, Joshua M. Wieting, Kyle A. Emmitte, Madeline F. Long, Alice L. Rodriguez, Anna L. Blobaum
Publikováno v:
Journal of Medicinal Chemistry. 62:378-384
A scaffold hopping exercise from a monocyclic mGlu2 NAM with poor rodent PK led to two novel heterobicyclic series of mGlu2 NAMs based on either a functionalized pyrazolo[1,5- a]pyrimidine-5-carboxamide core or a thieno[3,2- b]pyridine-5-carboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa63b24c5c476a59c658718b488936d
https://doi.org/10.1021/acs.jmedchem.8b01266
https://doi.org/10.1021/acs.jmedchem.8b01266
Autor:
Anna L. Blobaum, Jerri M. Rook, Jonathan W. Dickerson, Colleen M. Niswender, Julie L. Engers, Hekyung P Cho, Elizabeth S. Childress, Darren W. Engers, Rory A. Capstick, P. Jeffrey Conn, Craig W. Lindsley, Vincent B. Luscombe, Madeline F. Long
Publikováno v:
ACS Medicinal Chemistry Letters. 9:917-922
[Image: see text] Herein, we report the chemical optimization of a new series of M(1) positive allosteric modulators (PAMs) based on a novel pyrrolo[2,3-b]pyridine core, developed via scaffold hopping and iterative parallel synthesis. The vast majori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7814bce28c4b007cc453c0d3f611c1b2
https://doi.org/10.1021/acsmedchemlett.8b00261
https://doi.org/10.1021/acsmedchemlett.8b00261
Publikováno v:
Journal of Medicinal Chemistry. 61:4641-4655
Small molecule mitochondrial uncouplers transport protons from the mitochondrial inner membrane space into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP generation. The therapeutic potential of mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68fe9a3165bc1841d15220b4b5561d93
https://doi.org/10.1021/acs.jmedchem.7b01182
https://doi.org/10.1021/acs.jmedchem.7b01182
Autor:
Kevin R. Lynch, Yugesh Kharel, Webster L. Santos, Anne M. Brown, David R. Bevan, Elizabeth S. Childress
Publikováno v:
Journal of Medicinal Chemistry. 60:3933-3957
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its five G-protein coupled receptors (S1P1–5) to regulate cell growth and survival and has been implicated in a variety of diseases including cancer and sickle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6160b8a341233c06b1eeb2e4fcc593a3
https://doi.org/10.1021/acs.jmedchem.7b00233
https://doi.org/10.1021/acs.jmedchem.7b00233
Publikováno v:
The Journal of organic chemistry. 84(9)
Here we report the first synthesis of a family of novel heterocyclic compounds based on a 5-dihydropyrazolo[3',4':5,6]pyrano[3,4- b]pyridine core. In the course of our drug discovery programs, we had need to access the previously unknown 5-dihydropyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da460a3fcf08f2138855490e0f4b0b33
https://pubmed.ncbi.nlm.nih.gov/30807155
https://pubmed.ncbi.nlm.nih.gov/30807155
Autor:
Elizabeth S. Childress, Webster L. Santos, Frank Gillam, Jeannine S. Strobl, Masoud Agah, Chenming Zhang, Vaishnavi Srinivasaraghavan, Hesam Babahosseini, Zongmin Zhao
Publikováno v:
Lab on a Chip
A microfluidic chip developed to study the effects of free-drug versus NPs-mediated drug delivery on cancer cells using their electromechanical biomarkers.
Cancer progression and physiological changes within the cells are accompanied by alterati
Cancer progression and physiological changes within the cells are accompanied by alterati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c152e246c298a2b5665c486b5e372f9b
https://doi.org/10.1039/c5lc01201e
https://doi.org/10.1039/c5lc01201e