Výsledky vyhledávání - "Elizabeth Ramos-Morales"

Structure-activity studies of 1,2,4-oxadiazoles for the inhibition of the NAD+ dependent lysine deacylase Sirtuin2

Autor: Arianna Colcerasa, Jelena Melesina, Patrick Moser, Anja Vogelmann, Florian Friedrich, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Gross, Wolfgang Sippl, Manfred Jung

The NAD+-dependent lysine deacylase Sirtuin2 (Sirt2) is involved in multiple pathological conditions, including cancer. Targeting Sirt2 has thus received an increased interest for therapeutic purpose, including the ortholog from Schistosoma mansoni (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14bc1d79ad63cc86730b8191549ebacd
https://doi.org/10.26434/chemrxiv-2023-7x8pz

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Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni

Autor: Muhammad Murtaza Hassan, Abootaleb Sedighi, Olasunkanmi O. Olaoye, Cécile Häberli, Annika Merz, Elizabeth Ramos‐Morales, Elvin D. de Araujo, Christophe Romier, Manfred Jung, Jennifer Keiser, Patrick T. Gunning

Publikováno v: ChemMedChem. 17(18)

Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe1eaabb042d7d4205d0c4f9b3731bb
https://pubmed.ncbi.nlm.nih.gov/35983937

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Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 37, ⟨10.1016/j.celrep.2021.110129⟩

Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries, thus, represents a valid approach to fighting parasitic diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ace4f324f4075f85756d3020e718daf
https://pubmed.ncbi.nlm.nih.gov/34936867

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The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

Autor: Jordi Del-Pozo-Rodríguez, Christophe Romier, Peggy Tilly, Elizabeth Ramos-Morales, Thalia Salinas-Giegé, Eric Ennifar, Efil Bayam, Edouard Troesch, Martin Marek, Philippe Wolff, Juliette D. Godin, Laurence Drouard

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, 49 (11), pp.6529-6548. ⟨10.1093/nar/gkab436⟩
Nucleic Acids Research, 2021, 49 (11), pp.6529-6548. ⟨10.1093/nar/gkab436⟩
Nucleic acids research

Post-transcriptional modification of tRNA wobble adenosine into inosine is crucial for decoding multiple mRNA codons by a single tRNA. The eukaryotic wobble adenosine-to-inosine modification is catalysed by the ADAT (ADAT2/ADAT3) complex that modifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3049956f50a214bd85cb77744940af2f
https://hal.archives-ouvertes.fr/hal-03282247/document

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Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from

Autor: Daria, Monaldi, Dante, Rotili, Julien, Lancelot, Martin, Marek, Nathalie, Wössner, Alessia, Lucidi, Daniela, Tomaselli, Elizabeth, Ramos-Morales, Christophe, Romier, Raymond J, Pierce, Antonello, Mai, Manfred, Jung

Publikováno v: Journal of medicinal chemistry. 62(19)

The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ec21040e92d40996e35c3f07a830dd4
https://pubmed.ncbi.nlm.nih.gov/31496251

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Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

Autor: Raymond J. Pierce, Nathalie Wössner, Christophe Romier, Elizabeth Ramos-Morales, Daria Monaldi, Antonello Mai, Dante Rotili, Manfred Jung, Alessia Lucidi, Julien Lancelot, Daniela Tomaselli, Martin Marek

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩
Journal of Medicinal Chemistry, 2019, 62 (19), pp.8733-8759. ⟨10.1021/acs.jmedchem.9b00638⟩

The standard drug for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance to this treatment makes the research on novel therapeutic agents necessary and urgent. To this end, the targeting of Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590f6837f9fd9369c77a49ed274ed34
https://doi.org/10.26434/chemrxiv.7957544.v1

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