Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elizabeth R. Sprague"'
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 268K, Figure S2. LJM716 inhibits HER3 mediated PI3K signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45aed25076d0e9d1013eb0646b27aeb1
https://doi.org/10.1158/0008-5472.22396491.v1
https://doi.org/10.1158/0008-5472.22396491.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 459K, Figure S1. HER2, HER3 and members of the PI3K signaling pathway are activated in HER2 amplified cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86548e62b2a877ed8988ea2fa0e960b5
https://doi.org/10.1158/0008-5472.22396494.v1
https://doi.org/10.1158/0008-5472.22396494.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 181K, Figure S8. PIK3CA mutation is associated with reduced activity contributed by Trastuzumab (T) in Trastuzumab + LJM716 (L) combinations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1935d2ce8c30a6516c913bc1f80d67
https://doi.org/10.1158/0008-5472.22396473.v1
https://doi.org/10.1158/0008-5472.22396473.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 237K, Figure S5. Combination treatment consisting of trastuzumab+LJM716 or Cetuximab+LJM716 is well tolerated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1da5758fc8ca3d4818b19d0e7cea89c
https://doi.org/10.1158/0008-5472.22396482
https://doi.org/10.1158/0008-5472.22396482
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 272K, Figure S4. The NRG1/ HER3 binding affinity is unaffected by LJM716.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9905ed13c63505a9745e221ae07856d3
https://doi.org/10.1158/0008-5472.22396485.v1
https://doi.org/10.1158/0008-5472.22396485.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 204K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e713f2d3e336ae68588d5dfbe600adb
https://doi.org/10.1158/0008-5472.22396467.v1
https://doi.org/10.1158/0008-5472.22396467.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
HER2/HER3 dimerization resulting from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activation of phosphoinositide 3-kinase (PI3K) signaling. Although ligand-blocking HER3 antibodies inhibit NRG1-driven tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e0f1b0b51f8f53719c3b0b278caaae
https://doi.org/10.1158/0008-5472.c.6504582.v1
https://doi.org/10.1158/0008-5472.c.6504582.v1
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 1205K, Figure S7. Treatment of HER2 amplified cell lines with LJM716/ trastuzumab combinations is synergistic in a subset of cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c3b8508bdb81b5b8889de952f8a993
https://doi.org/10.1158/0008-5472.22396476
https://doi.org/10.1158/0008-5472.22396476
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 239K, Figure S3. LJM716 is specific for HER3 and binds a conformational epitope that includes key residues in D2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee576876ad11deb810bfc9827362234
https://doi.org/10.1158/0008-5472.22396488
https://doi.org/10.1158/0008-5472.22396488
Autor:
Seth A. Ettenberg, William R. Sellers, Carlos L. Arteaga, Alwin Schuller, Joshua Murtie, Kara Herlihy, Analeah B. Heidt, Christian Kunz, Winfried Elis, Manuela Haberl, Carolin Zehetmeier, Nicole Haubst, Alan Huang, Jian Gu, Rebecca Mosher, Rita Das, Jinsheng Liang, Huiqin Wang, Yan Chen, Dongshu Chen, Cammie R. Sutton, Parmita Saxena, Olga Sineshchekova, Sharon Li, Qing Sheng, Joan T. Garrett, Elizabeth R. Sprague, Carl U. Bialucha, Andrew P. Garner
PDF file - 114K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01af4451777148cf96ef3983240402d5
https://doi.org/10.1158/0008-5472.22396470.v1
https://doi.org/10.1158/0008-5472.22396470.v1