Výsledky vyhledávání - "Elizabeth R. Smithwick"

Role of Secondary Coordination Sphere Residues in Halogenation Catalysis of Non-heme Iron Enzymes

Autor: R. Hunter Wilson, Sourav Chatterjee, Elizabeth R. Smithwick, Joseph J. Dalluge, Ambika Bhagi-Damodaran

Publikováno v: ACS Catalysis. 12:10913-10924

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42e0dc578794ff4cd04eec22a75fe142
https://doi.org/10.1021/acscatal.2c00954

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Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases

Autor: Elizabeth R. Smithwick, R. Hunter Wilson, Sourav Chatterjee, Yu Pu, Joseph J. Dalluge, Anoop Rama Damodaran, Ambika Bhagi-Damodaran

Publikováno v: bioRxiv

Non-heme iron halogenases (NHFe-Hals) catalyze the direct insertion of a chloride/bromide ion at an unactivated carbon position using a high-valent haloferryl intermediate. Despite more than a decade of structural and mechanistic characterization, ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a728a40cd623acf81c5442b5c8de8e25
https://europepmc.org/articles/PMC10245910/

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Role of a secondary coordination sphere residue in halogenation catalysis of non-heme iron enzymes

Autor: R. Hunter Wilson, Sourav Chatterjee, Elizabeth R. Smithwick, Joe J. Dalluge, Ambika Bhagi-Damodaran

Chemo- and regio-selective catalysis of C(sp3)-H halogenation reaction is a formidable goal in chemical synthesis. 2-oxo-glutarate (2OG) dependent non-heme iron halogenases catalyze selective chlorination/bromination of C-H bonds and exhibit high seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d30c3478c295ec931ef59a3e2351b5a
https://doi.org/10.26434/chemrxiv-2022-61wck

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2′-Deoxy-2′-fluoro-arabinonucleic acid: a valid alternative to DNA for biotechnological applications using charge transport

Autor: Elizabeth R. Smithwick, Agostino Migliore, Ruijie D. Teo

Publikováno v: Phys Chem Chem Phys

The non-biological 2’-deoxy-2’-fluoro-arabinonucleic acid (2’F-ANA) may be used as a valid alternative to DNA in biomedical and electronic applications because of its higher resistance to hydrolysis and nuclease degradation. However, the advant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359add93574487fad126d723ef79033d
https://doi.org/10.1039/c9cp04805g

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Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling

Autor: Rosa Di Felice, Ruijie D. Teo, David N. Beratan, Agostino Migliore, Benjamin J. G. Rousseau, Elizabeth R. Smithwick

Publikováno v: Chem (Cambridge. Online) 5 (2019): 122–137. doi:10.1016/j.chempr.2018.09.026
info:cnr-pdr/source/autori:Teo R.D.; Rousseau B.J.G.; Smithwick E.R.; Di Felice R.; Beratan D.N.; Migliore A./titolo:Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling/doi:10.1016%2Fj.chempr.2018.09.026/rivista:Chem (Cambridge. Online)/anno:2019/pagina_da:122/pagina_a:137/intervallo_pagine:122–137/volume:5

Recent experiments suggest that DNA-mediated charge transport might enable signaling between the [4Fe4S] clusters in the C-terminal domains of human DNA primase and polymerase α, as well as the signaling between other replication and repair high-pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b75f9279390e48b643015533bc7d9
http://hdl.handle.net/11577/3365114

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A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation

Autor: David N. Beratan, Ruijie D. Teo, Elizabeth R. Smithwick, Agostino Migliore

Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5556f63bcd94b0223afe6e0dff1c0ef5
http://hdl.handle.net/11577/3365120

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Mapping hole hopping escape routes in proteins

Autor: Elizabeth R. Smithwick, David N. Beratan, Michael J. Therien, Ruijie D. Teo, Agostino Migliore, Ruobing Wang

A recently proposed oxidative damage protection mechanism in proteins relies on hole hopping escape routes formed by redox-active amino acids. We present a computational tool to identify the dominant charge hopping pathways through these residues bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d0225659497b2da4e5d698622ab932
http://hdl.handle.net/11577/3365113

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Designed Ankyrin Repeat Proteins: A Look at their Evolving Use in Medicine with a Focus on the Treatment of Chorioretinal Vascular Disorders

Autor: Elizabeth R. Smithwick, Michael W. Stewart

Publikováno v: Anti-inflammatoryanti-allergy agents in medicinal chemistry. 16(1)

Background: Antibodies constitute an important drug development platform for drugs to treat several ophthalmic, oncologic, and immunologic conditions, but due to limitations inherent in antibody production and structure, a wide range of other protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba46ae4ccaca9122896756f0b5e1f753
https://pubmed.ncbi.nlm.nih.gov/28464780

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