Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Elizabeth R Duke"'
Autor:
E Fabian Cardozo-Ojeda, Elizabeth R Duke, Christopher W Peterson, Daniel B Reeves, Bryan T Mayer, Hans-Peter Kiem, Joshua T Schiffer
Publikováno v:
eLife, Vol 10 (2021)
Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To projec
Externí odkaz:
https://doaj.org/article/e4fa43b65ac8466fba011375655a9c96
Autor:
Daniel B Reeves, Yunda Huang, Elizabeth R Duke, Bryan T Mayer, E Fabian Cardozo-Ojeda, Florencia A Boshier, David A Swan, Morgane Rolland, Merlin L Robb, John R Mascola, Myron S Cohen, Lawrence Corey, Peter B Gilbert, Joshua T Schiffer
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007626 (2020)
The ongoing Antibody Mediated Prevention (AMP) trials will uncover whether passive infusion of the broadly neutralizing antibody (bNAb) VRC01 can protect against HIV acquisition. Previous statistical simulations indicate these trials may be partially
Externí odkaz:
https://doaj.org/article/b57609ab3ca948799af4d9654506360b
Autor:
Florencia A. Tettamanti Boshier, Daniel B. Reeves, Elizabeth R. Duke, David A. Swan, Martin Prlic, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer
Publikováno v:
Journal of Virus Eradication, Vol 8, Iss 4, Pp 100091- (2022)
The HIV reservoir is a population of 1–10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication
Externí odkaz:
https://doaj.org/article/288b3e7c136f4bc8a6639690c4e7cf24
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104448- (2022)
Summary: In clinical trials, remdesivir decreased recovery time in hospitalized patients with SARS- CoV-2 and prevented hospitalization when given early during infection, despite not reducing nasal viral loads. In rhesus macaques, early remdesivir pr
Externí odkaz:
https://doaj.org/article/2f1df64e83674b2fa00b65bb9e211b69
Autor:
Daniel B. Reeves, Elizabeth R. Duke, Thor A. Wagner, Sarah E. Palmer, Adam M. Spivak, Joshua T. Schiffer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generate
Externí odkaz:
https://doaj.org/article/d3e708e779664bdfbeec752fe51d1be0
Autor:
Elizabeth R. Duke, Florencia A. T. Boshier, Michael Boeckh, Joshua T. Schiffer, E. Fabian Cardozo-Ojeda
Publikováno v:
Viruses, Vol 13, Iss 11, p 2292 (2021)
Cytomegalovirus (CMV) causes significant morbidity and mortality in recipients of allogeneic hematopoietic cell transplantation (HCT). Whereas insights gained from mathematical modeling of other chronic viral infections such as HIV, hepatitis C, and
Externí odkaz:
https://doaj.org/article/2167d503aa2f4a6caf767800792aae40
Autor:
Daniel B. Reeves, Elizabeth R. Duke, Sean M. Hughes, Martin Prlic, Florian Hladik, Joshua T. Schiffer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract In the era of antiretroviral therapy (ART), HIV-1 infection is no longer tantamount to early death. Yet the benefits of treatment are available only to those who can access, afford, and tolerate taking daily pills. True cure is challenged by
Externí odkaz:
https://doaj.org/article/3bd56a0f58ac4f5799ab988ad7daaffa
BK viremia and changes in eGFR in children and young adults after hematopoietic cell transplantation
Autor:
Chiara, Wychera, Hannah N, Imlay, Elizabeth R, Duke, Anna, Faino, Meei, Li-Huang, Terry, Stevens-Ayers, Chris, Davis, Baerbel, Lange-Sperandio, Kanwaldeep K, Mallhi, Joshua A, Hill, Michael, Boeckh, Janet A, Englund, Sangeeta, Hingorani
Publikováno v:
Transplantation and cellular therapy.
Kidney disease in allogeneic hematopoietic cell transplant (HCT) recipients is associated with increased mortality rates. BK virus (BKV) viremia has been associated with kidney dysfunction in pediatric HCT recipients, however, few studies have invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa605c46df685508436ce7dc6fac726e
https://pubmed.ncbi.nlm.nih.gov/36494016
https://pubmed.ncbi.nlm.nih.gov/36494016
Autor:
Lisa So, Jordan Gauthier, Andrew J. Cowan, Cameron J. Turtle, Leah M. Yoke, Madeleine R. Heldman, Elizabeth R. Duke, Joshua A. Hill, Catherine Liu, Riley A O'Hara, Elizabeth A Gulleen, Jimmy Ma
Publikováno v:
J Immunother
Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394a8dd35d47d7155d69795264f5a43d
https://doi.org/10.1097/cji.0000000000000388
https://doi.org/10.1097/cji.0000000000000388
Autor:
Danniel Zamora, Hu Xie, Wendy M. Leisenring, Brenda Akoto, Joshua T. Schiffer, Stephen C. De Rosa, Elizabeth R. Duke, Ralf Wagner, Terry Stevens-Ayers, Greg Finak, Bradley C. Edmison, Michael Boeckh, Richard Kiener, Keith R. Jerome, Marco Mielcarek
Publikováno v:
Blood. 138:34-43
Decreased cytomegalovirus (CMV)-specific immunity after hematopoietic cell transplantation (HCT) is associated with late CMV reactivation and increased mortality. Whether letermovir prophylaxis-associated reduction in viral exposure influences CMV-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed5cf39c7c48067dc0d89c7d060c257
https://doi.org/10.1182/blood.2020009396
https://doi.org/10.1182/blood.2020009396