Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elizabeth R, Leight"'
Autor:
Amanda M. Smith, Angela M. Verdoni, Haley J. Abel, David Y. Chen, Shamika Ketkar, Elizabeth R. Leight, Christopher A. Miller, Timothy J. Ley
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104004- (2022)
Summary: Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knocko
Externí odkaz:
https://doaj.org/article/01b3d370f1c6454ba941449503cd5b03
Autor:
Mieke Hoock, Catrina Fronick, Gue Su Chang, Angela M. Verdoni, David H. Spencer, Elizabeth R. Leight, Robert S. Fulton, Celia V. Bangert, Christopher A. Miller, Meryl K. Brune, Nichole M. Helton, Timothy J. Ley, Amanda Smith, Daniel R. George, David Y. Chen, Sai Mukund Ramakrishnan, Shamika Ketkar, Allegra A. Petti
Publikováno v:
Proceedings of the National Academy of Sciences. 117:3123-3134
Mutations in the DNA methyltransferase 3A ( DNMT3A ) gene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and are among the most common initiating events for acute myeloid leukemia (AML). The most frequent D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a73828fa5a10b09980e27c95b12a85a7
https://doi.org/10.1073/pnas.1918611117
https://doi.org/10.1073/pnas.1918611117
Autor:
Amanda M, Smith, Angela M, Verdoni, Haley J, Abel, David Y, Chen, Shamika, Ketkar, Elizabeth R, Leight, Christopher A, Miller, Timothy J, Ley
Publikováno v:
iScience. 25(4)
Mutations in the gene encoding DNA methyltransferase 3A (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::158585263ff31de8e71ff06d7c45afae
https://pubmed.ncbi.nlm.nih.gov/35313694
https://pubmed.ncbi.nlm.nih.gov/35313694
Autor:
Shamika, Ketkar, Angela M, Verdoni, Amanda M, Smith, Celia V, Bangert, Elizabeth R, Leight, David Y, Chen, Meryl K, Brune, Nichole M, Helton, Mieke, Hoock, Daniel R, George, Catrina, Fronick, Robert S, Fulton, Sai Mukund, Ramakrishnan, Gue Su, Chang, Allegra A, Petti, David H, Spencer, Christopher A, Miller, Timothy J, Ley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mutations that reduce the function of the de novo DNA methyltransferase, DNMT3A, are very common in patients with clonal hematopoiesis and hematopoietic malignancies. Restoring the function of DNMT3A in mouse hematopoietic cells deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5880c8fc6f1e2d090f24ad74042b015
https://pubmed.ncbi.nlm.nih.gov/31996479
https://pubmed.ncbi.nlm.nih.gov/31996479
Autor:
Elizabeth R. Leight, Sai Mukund Ramakrishnan, Shamika Ketkar, Amanda Smith, Timothy J. Ley, Angela M. Verdoni, Christopher A. Miller, Haley J. Abel, David Y. Chen
Publikováno v:
Blood. 138:1087-1087
Introduction Somatic mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis, and among the most common initiating events for acute myeloid leukemia (AML). Constitutional DNMT3A mutations cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9855b6602d6e9c7ae19ade4ecb8cd4
https://doi.org/10.1182/blood-2021-150558
https://doi.org/10.1182/blood-2021-150558
Autor:
Timothy J. Ley, Vincent Magrini, Shamika Ketkar, Christopher B Cole, Angela M. Verdoni, Elizabeth R. Leight, David A. Russler-Germain, Tamara Lamprecht, Ryan Demeter
The DNA methyltransferases DNMT3A and DNMT3B are primarily responsible for de novo methylation of specific cytosine residues in CpG dinucleotides during mammalian development. While loss-of-function mutations in DNMT3A are highly recurrent in acute m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2870d3a0914384b97a70a664516571a3
https://europepmc.org/articles/PMC4701540/
https://europepmc.org/articles/PMC4701540/
Autor:
Thomas M. Ratliff, Duaa H Mohammad, Daniel Schneider, Elizabeth R. Leight, Douglas A. Fantz, John T. Murphy, Michael A. Herman, Kerry Kornfeld, Danielle Pepin
Publikováno v:
Genetics. 199(3)
The LIN-1 ETS transcription factor plays a pivotal role in controlling cell fate decisions during development of the Caenorhabditis elegans vulva. Prior to activation of the RTK/Ras/ERK-signaling pathway, LIN-1 functions as a SUMOylated transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bddf1c8f659e99f9be2a48ae8830f2
https://pubmed.ncbi.nlm.nih.gov/25567989
https://pubmed.ncbi.nlm.nih.gov/25567989
Autor:
Bill Sugden, Elizabeth R. Leight
Publikováno v:
Reviews in Medical Virology. 10:83-100
Epstein-Barr nuclear antigen 1, or EBNA-1, is required for the replication of the EBV genome as an extra-chromosomal element and is a key transcriptional regulator of this virus's latent gene expression. In this review we will describe the salient fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ca6fbfcd49c8d004befc7ac6e1c7fcf
https://doi.org/10.1002/(sici)1099-1654(200003/04)10:2<83::aid-rmv262>3.0.co
https://doi.org/10.1002/(sici)1099-1654(200003/04)10:2<83::aid-rmv262>3.0.co
Publikováno v:
Molecular and cellular biology. 26(3)
We developed a mammalian plasmid replicon with a formerly uncharacterized origin of DNA synthesis, 8xRep*. 8xRep* functions efficiently to support once-per-cell-cycle synthesis of plasmid DNA which initiates within Rep*. By characterizing Rep*'s requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3648a5d19369cc417f58ffc0d66d689f
https://pubmed.ncbi.nlm.nih.gov/16428463
https://pubmed.ncbi.nlm.nih.gov/16428463
Publikováno v:
Development (Cambridge, England). 132(5)
The LIN-1 ETS transcription factor inhibits vulval cell fates during Caenorhabditis elegans development. We demonstrate that LIN-1 interacts with UBC-9, a small ubiquitin-related modifier (SUMO) conjugating enzyme. This interaction is mediated by two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b83b04d509c622eb03a2fb1cafb4f3
https://pubmed.ncbi.nlm.nih.gov/15689373
https://pubmed.ncbi.nlm.nih.gov/15689373