Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Elizabeth R, Lawlor"'
Autor:
David S. Shulman, Sarah B. Whittle, Didier Surdez, Kelly M. Bailey, Enrique de Álava, Jason T. Yustein, Adam Shlien, Masanori Hayashi, Alexander J. R. Bishop, Brian D. Crompton, Steven G. DuBois, Neerav Shukla, Patrick J. Leavey, Stephen L. Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G. P. Grünewald, Cristina R. Antonescu, Ryan D. Roberts, Jeffrey A. Toretsky, Franck Tirode, Richard Gorlick, Katherine A. Janeway, Damon Reed, Elizabeth R. Lawlor, Patrick J. Grohar
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60–80% of patien
Externí odkaz:
https://doaj.org/article/85d5d49a92054aefa68b0e44c262da64
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Accumulating evidence shows that despite clonal origins tumors eventually become complex communities comprised of phenotypically distinct cell subpopulations. This heterogeneity arises from both tumor cell intrinsic programs and signals from spatiall
Externí odkaz:
https://doaj.org/article/de6dbdf498164f3baec44e9a66e65492
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Primary bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive tumors with peak incidence in childhood and adolescence. The intense standard treatment for these patients consists of combined surgery and/or radiation and max
Externí odkaz:
https://doaj.org/article/e59c3ba5438247f78fac6de46efc7628
Autor:
Allegra G. Hawkins, Claire M. Julian, Sonja Konzen, Sydney Treichel, Elizabeth R. Lawlor, Kelly M. Bailey
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 1063-1072 (2019)
Ewing sarcoma is a bone tumor most commonly diagnosed in adolescents and young adults. Survival for patients with recurrent or metastatic Ewing sarcoma is dismal and there is a dire need to better understand the mechanisms of cell metastasis specific
Externí odkaz:
https://doaj.org/article/df1cad9c71c6453ba765790c2becb9ca
Autor:
Dipika R. Mohan, Kleiton S. Borges, Isabella Finco, Christopher R. LaPensee, Juilee Rege, April L. Solon, Donald W. Little, Tobias Else, Madson Q. Almeida, Derek Dang, James Haggerty-Skeans, April A. Apfelbaum, Michelle Vinco, Alda Wakamatsu, Beatriz M. P. Mariani, Larissa Costa. Amorim, Ana Claudia. Latronico, Berenice B. Mendonca, Maria Claudia N. Zerbini, Elizabeth R. Lawlor, Ryoma Ohi, Richard J. Auchus, William E. Rainey, Suely K.N. Marie, Thomas J. Giordano, Sriram Venneti, Maria Candida Barisson Villares Fragoso, David T. Breault, Antonio Marcondes. Lerario, Gary D. Hammer
Publikováno v:
Cancer Research.
Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9890ecf1e233fe62894cabb8c7c08c
https://doi.org/10.1158/0008-5472.can-22-2712
https://doi.org/10.1158/0008-5472.can-22-2712
Autor:
Emma D. Wrenn, April A. Apfelbaum, Erin R. Rudzinski, Xuemei Deng, Wei Jiang, Sudha Sud, Raelene A. Van Noord, Erika A. Newman, Nicolas M. Garcia, Virginia J. Hoglund, Shruti S. Bhise, Sami B. Kanaan, Olivia G. Waltner, Scott N. Furlan, Elizabeth R. Lawlor
Tumor heterogeneity is a major driver of cancer progression. In epithelial-derived malignancies, carcinoma-associated fibroblasts (CAFs) contribute to tumor heterogeneity by depositing extracellular matrix (ECM) proteins that dynamically remodel the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16ce955eb8cbeacfb9254b68d6a8df8
https://doi.org/10.1101/2023.04.12.536619
https://doi.org/10.1101/2023.04.12.536619
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
GSK-LSD1, Doxorubicin and AraC have no effect on KDM1A and KDM1B expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1051ce09797e7b498c067f204794a86
https://doi.org/10.1158/1535-7163.22509571.v1
https://doi.org/10.1158/1535-7163.22509571.v1
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Protein expression of ER-stress response genes following treatment with SP-2509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0388e4ca3b246780959d79b84a856ff2
https://doi.org/10.1158/1535-7163.22509565.v1
https://doi.org/10.1158/1535-7163.22509565.v1
Autor:
Elizabeth R. Lawlor, Costas A. Lyssiotis, Jolanta Grembecka, Tomasz Cierpicki, Dong Chen, Trupta Purohit, Joshua Bradin, Zeribe C. Nwosu, Elena Haarer, Alessandra X. Garcia, Ramon Ocadiz Ruiz, Abhijay Kumar, Laurie K. Svoboda, Allegra G. Hawkins, April A. Apfelbaum, Jennifer A. Jiménez
Supplementary Figure S1. Real-time cell proliferation analysis of shATF4, MI-503 treatment, and dox-inducible shMEN1 knockdown in Ewing sarcoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65896b8b3795e1db6d930758a68a4535
https://doi.org/10.1158/1541-7786.22526076
https://doi.org/10.1158/1541-7786.22526076
Autor:
Stephen L. Lessnick, Sunil Sharma, David F. Callen, Mary C. Beckerle, Olivier Delattre, Jaume Mora, Franck Tirode, Elizabeth R. Lawlor, Brian D. Crompton, Ioana L. Pop, Ranajeet S. Saund, Kirsten M. Johnson, Emily R. Theisen, Cenny Taslim, Christina D. Drenberg, Kathleen I. Pishas
Targeted KDM1A inhibition and EWS/FLI knockdown induces similar transcriptional signatures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43708ed7fd5e4213822a969dd241bbbf
https://doi.org/10.1158/1535-7163.22509577
https://doi.org/10.1158/1535-7163.22509577