Blood and immune development in human fetal bone marrow and Down syndrome

Autor: Nicola K. Wilson, Michal Slyper, David Dixon, Gary Reynolds, Emily Stephenson, Berthold Göttgens, Irene Roberts, Petra Balogh, Anindita Roy, Bo Li, Monika S. Kowalczyk, Aviv Regev, Nicole Mende, Hamish W King, Iwo Kucinski, Laura Jardine, Mirjana Efremova, Meghan Acres, Orr Ashenberg, Caroline Shrubsole, Thomas Creasey, Dave Horsfall, Mika Sarkin Jain, Simone Webb, Elizabeth Poyner, Steven Lisgo, Rachel Queen, Kerstin B. Meyer, Kirsty Ambridge, John E. Lawrence, Natalina Elliott, Elena Prigmore, Jaume Bacardit, Rachel A. Botting, Danielle Dionne, Muzlifah Haniffa, Justin Engelbert, Marcin Tabaka, Rafiqul Hussain, Myriam L. R. Haltalli, Christopher D. Carey, Thomas Ness, Bayanne Olabi, Deborah J. Henderson, Daniel Maunder, Elisa Laurenti, Keir Pickard, Orit Rozenblatt-Rosen, Rowen Coulthard, Jim McGrath, Sam Behjati, Issac Goh, David McDonald, Sorcha O’Byrne, Timothy L. Tickle, Emma Dann, Claire G. Jones, Sarah A. Teichmann, Caitlin Murnane, Dorin-Mirel Popescu, Jonathan Coxhead, Mariana Quiroga Londoño, Michael W. Mather, Andrew Filby

Publikováno v: Nature

Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after conception1,2, yet almost nothing is known about how fetal BM (FBM) evolves t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616a4b608e777594fb92efca1fe30968
https://doi.org/10.1038/s41586-021-03929-x

Developmental cell programs are co-opted in inflammatory skin disease

Autor: Emily Stephenson, Anna Dubois, C Jones, David McDonald, Tzachi Hagai, Mirjana Efremova, Neil Rajan, Kile Green, Gary Reynolds, Roser Vento-Tormo, James Fletcher, Graham S. Ogg, Sam Behjati, Simone Webb, Elizabeth Poyner, Steven Lisgo, Bayanne Olabi, David Dixon, Edel A. O'Toole, Justin Engelbert, Daniel Maunder, Alexandra-Chloé Villani, Magnus D. Lynch, Victor A. Negri, A. Husain, Ni Huang, Krzysztof Polanski, Dorin-Mirel Popescu, Kerstin B. Meyer, Andrew Filby, Muzlifah Haniffa, Rachel A. Botting, Jim McGrath, Peter Vegh, Laura Jardine, Ben Sayer, Daria Belokhvostova, Fiona M. Watt, Xiao-Nong Wang, Thomas Ness, Dave Horsfall, Nick J. Reynolds, Jaume Bacardit, Sarah A. Teichmann, Jong-Eun Park, Philip H. Jones, Jonathan Coxhead, Christopher D. Carey, Issac Goh

Publikováno v: Science. 371

Cellular beauty is skin deep Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a5019522460b488c82de080b6bbf9e
https://doi.org/10.1126/science.aba6500

Décodage de l'hématopoïèse fétale hépatique humaine

Autor: Ben Millar, Laura Jardine, Rachel Rowell, Gary Reynolds, Sarah A. Teichmann, Anindita Roy, Orit Rozenblatt-Rosen, Emily Stephenson, Elisa Laurenti, Michal Slyper, Issac Goh, Aviv Regev, Frankie Greig, Lira Mamanova, Orr Ashenberg, Monika S. Kowalczyk, Barbara A. Innes, Jong-Eun Park, David McDonald, Berthold Göttgens, Corina Moldovan, Kile Green, Matthew D. Young, Danielle Dionne, Peter D. Carey, Irene Roberts, Mirjana Efremova, Zhichao Miao, Rachel A. Botting, Alain Chédotal, Simone Webb, Bo Li, Elizabeth Poyner, Steven Lisgo, Marcin Tabaka, Peter Vegh, Andrew Fuller, Yorick Gitton, Roser Vento-Tormo, Susan Lindsay, David Dixon, Sam Behjati, Meghan Acres, Alexandra-Chloé Villani, Michael J. T. Stubbington, Jaume Bacardit, Emily Calderbank, Dorin-Mirel Popescu, Daniel Maunder, Krzysztof Polanski, James Fletcher, Michael W. Mather, Kerstin B. Meyer, Timothy L. Tickle, Andrew Filby, Muzlifah Haniffa

Publikováno v: Nature
Nature, Nature Publishing Group, 2019, 574, pp.365-371. ⟨10.1038/s41586-019-1652-y⟩
Nature, Nature Publishing Group, 2019, 574 (7778), pp.365-371. ⟨10.1038/s41586-019-1652-y⟩

International audience; Definitive haematopoiesis in the fetal liver supports self-renewal anddifferentiation of haematopoietic stem cells and multipotent progenitors(HSC/MPPs) but remains poorly defined in humans. Here, using single-celltranscriptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2c8813ac4ea92ac6e1ca1e722aab2
https://www.repository.cam.ac.uk/handle/1810/297663

Renal allograft rejection: Examination of delayed differentiation of Treg and Th17 effector T cells

Autor: Sarah Jenkinson, John A. Kirby, Elizabeth Poyner, Simi Ali, Joseph D. P. Willet, Marcin L. Pekalski, Abdulaziz H. Alhamidi, Helen Robertson

Publikováno v: Immunobiology. 218:303-310

Antigen presentation after kidney transplantation occurs in lymphoid tissues remote from the allograft, with activated T cells then migrating towards the graft. This study examined the possibility that these activated T cells can differentiate to acq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9e962d58dc9ed90b039e4f2f459a68
https://doi.org/10.1016/j.imbio.2012.05.014

Population of Monocyte-Derived Macrophages

Autor: Duan Kaibo, Kile Green, Elizabeth Poyner, Laura Jardine, Rachel E. Dickinson, Sarah Pagan, Matthew Collin, Donovan Low, Venetia Bigley, Paul Milne, Samuel Covins, Muzlifah Haniffa, Martin Windebank, Anis Larbi, Florent Ginhoux, Xiao-Nong Wang, Amanda Shin, Andreas Schlitzer, Michael Poidinger, Diego Miranda-Saavedra, Merry Gunawan, Naomi McGovern, Khadija Aljefri, Katie Best, Pavandip Singh Wasan

Publikováno v: Immunity

Summary Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141hiXCR1+CLEC9A+ DCs and CD1c+ DCs are murine CD103+ D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18388faf0fbad3259d91dda9b5d09a93
https://doi.org/10.1016/j.immuni.2015.01.018