Výsledky vyhledávání - "Elizabeth N. Kaytor"

Insulin-responsive Nuclear Proteins Facilitate Sp1 Interactions with the Insulin-like Growth Factor-I Gene

Autor: Ching-I Pao, Elizabeth N. Kaytor, Lawrence S. Phillips, Juan Li Zhu

Publikováno v: Journal of Biological Chemistry. 276:36896-36901

The diabetes-induced decrease in insulin-like growth factor-I transcription appears to be mediated by footprint region V in exon 1. Since region V contains both an Sp1 site and an AT-rich element that recognizes an insulin-responsive binding protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c37da731e900703bef4acfca67d8b3c
https://doi.org/10.1074/jbc.m104035200

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Autor: Elizabeth N. Kaytor, J. Qian, L K Olson, Howard C. Towle

Publikováno v: Molecular and Cellular Biochemistry. 210:13-21

Transcription of the L-type pyruvate kinase (L-PK) and S14 genes is induced in hepatocytes in response to increased glucose metabolism. The regulatory sequences of these genes responsible for induction by glucose have been mapped to related E-box con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3f38c65a211327741174174c43eacc4
https://doi.org/10.1023/a:1007006429041

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Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic β-cells

Autor: Howard C. Towle, L K Olson, J. Qian, Elizabeth N. Kaytor

Publikováno v: Biochemical Journal. 341:315-322

The homeobox gene Pdx-1 plays a key role in the development of the pancreas. In the adult, however, expression of the Pdx-1 gene is restricted to pancreatic beta-cells and endocrine cells of duodenal epithelium. Recently, the transcription factor, up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::daf6b473aca26f33ffe6d14ec9ac3c7f
https://doi.org/10.1042/bj3410315

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REGULATION OF THE EXPRESSION OF LIPOGENIC ENZYME GENES BY CARBOHYDRATE

Autor: Howard C. Towle, Elizabeth N. Kaytor, Hsiu-Ming Shih

Publikováno v: Annual Review of Nutrition. 17:405-433

▪ Abstract Diets high in simple carbohydrates and low in fats lead in the mammalian liver to induction of a set of enzymes involved in lipogenesis. This induction occurs, in part, through transcriptional mechanisms that lead to elevated levels of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c32e3acb8a590243246d3061dc33f4
https://doi.org/10.1146/annurev.nutr.17.1.405

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Carbohydrate Regulation of Hepatic Gene Expression

Autor: Howard C. Towle, Elizabeth N. Kaytor, Hsiu-ming Shih

Publikováno v: Journal of Biological Chemistry. 272:7525-7531

Hepatic expression of the genes encoding L-type pyruvate kinase (L-PK) and S14 is induced in rats upon feeding them a high carbohydrate, low fat diet. A carbohydrate response element (ChoRE) containing two CACGTG-type E boxes has been mapped in the 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44e5fe693777003dca8074b09673274b
https://doi.org/10.1074/jbc.272.11.7525

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An insulin-response element-binding protein that ameliorates hyperglycemia in diabetes

Autor: Elizabeth N. Kaytor, Betty C. Villafuerte

Publikováno v: The Journal of biological chemistry. 280(20)

Insulin modulates glucose homeostasis, but the role of insulin-responsive transcription factors in such actions is not well understood. Recently, we have identified the insulin-response element-binding protein-1 (IRE-BP1) as a transcription factor th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24890a525f8f319c6e3f70a03bb46ea2
https://pubmed.ncbi.nlm.nih.gov/15753094

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Physiological concentrations of insulin promote binding of nuclear proteins to the insulin-like growth factor I gene

Autor: Elizabeth N. Kaytor, Lawrence S. Phillips, Juan Li Zhu, Ching-I Pao

Publikováno v: Endocrinology. 142(3)

Limitations in understanding the mechanism of transcriptional regulation by insulin are due in part to lack of models in which there is insulin-responsive binding of nuclear factors to critical promoter regions. The insulin-like growth factor I (IGF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd730eb97e951c809a1d7df48a0c4f
https://pubmed.ncbi.nlm.nih.gov/11181517

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