Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elizabeth Mutter-Rottmayer"'
Autor:
Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic i
Externí odkaz:
https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e
Autor:
Kenneth H. Pearce, An J, Elizabeth Mutter-Rottmayer, Yuchen Yang, Amélie Fradet-Turcotte, Jablonski Ae, Chen S, Anand, Yanzhe Gao, Hollingworth R, Jayaprakash D, Cyrus Vaziri, Simon Blanchet, Xiaolin Cheng, Grant S. Stewart
The E3 ligase RNF168 has been suggested to have roles at DNA replication forks in addition to its canonical functions in DNA double-strand break (DSB) signaling. However, the precise role of RNF168 in DNA replication remains unclear. Here we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25edc4b382d36f77afc0ee053590f114
https://doi.org/10.1101/2021.03.17.435897
https://doi.org/10.1101/2021.03.17.435897
Autor:
Jordan Kardos, Tigist Y. Tamir, Yang Yang, Cyrus Vaziri, William Y. Kim, Michael B. Major, Bernard E. Weissman, Elizabeth Mutter-Rottmayer, Yanzhe Gao
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antige
Publikováno v:
Genes, Vol 8, Iss 2, p 64 (2017)
Genes
Genes
Accurate DNA replication is crucial for cell survival and the maintenance of genome stability. Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise from both endogenous and environmental sources. Lesions encountered
Autor:
Judy Tung, Luoping Zhang, Elizabeth Mutter-Rottmayer, Martyn T. Smith, Zhiying Ji, Michele Fromowitz, Xiyi Li
Publikováno v:
Toxicology letters, vol 224, iss 2
Although formaldehyde (FA) has been classified as a human leukemogen, the mechanisms of leukemogenesis remain elusive. Previously, using colony-forming assays in semi-solid media, we showed that FA exposure in vivo and in vitro was toxic to human hem
Publikováno v:
Molecularcellular oncology. 3(6)
Trans-lesion synthesis (TLS) is a DNA damage-tolerant and error-prone mode of DNA replication. Recent work shows that many cancer cells coopt an aberrantly expressed germ cell protein, melanoma antigen-A4 (MAGE-A4), to activate TLS. MAGE-A4–induced
In response to DNA damage and DNA-replication stress, eukaryotic cells activate two postreplication repair (PRR) mechanisms to facilitate completion of DNA synthesis. A DNA damage–tolerance mechanism termed “trans-lesion synthesis” (TLS) uses e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9eeaa81d2aa54603a237f887d54a1de
https://doi.org/10.1016/b978-0-12-803309-8.00016-1
https://doi.org/10.1016/b978-0-12-803309-8.00016-1