Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Elizabeth Mroczek"'
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 47, Iss , Pp 102045- (2024)
Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been
Externí odkaz:
https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 79, Iss , Pp 102228- (2022)
Extramedullary hematopoiesis occurs in the setting of hematologic disorders or malignancies when the activity of the bone marrow is insufficient to generate blood cells. We report a unique case of adrenal extramedullary hematopoiesis diagnosed in a 1
Externí odkaz:
https://doaj.org/article/3b39eef208c945fd905b17175f0517e0
Autor:
Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Markert, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, David K. Crossman, Karina J. Yoon, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 14, Iss 7, Pp 101099- (2021)
Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric pa
Externí odkaz:
https://doaj.org/article/ba8c4f5263934279a3ed4ec995b89d8c
Autor:
Adele P. Williams, Evan F. Garner, Laura L. Stafman, Jamie M. Aye, Colin H. Quinn, Raoud Marayati, Jerry E. Stewart, Venkatram R. Atigadda, Elizabeth Mroczek-Musulman, Blake P. Moore, Elizabeth A. Beierle, Gregory K. Friedman
Publikováno v:
Translational Oncology, Vol 12, Iss 10, Pp 1364-1374 (2019)
PURPOSE: In spite of advances in therapy for some subtypes, group 3 medulloblastoma continues to portend a poor prognosis. A subpopulation of medulloblastoma cells expressing the cell surface marker CD133 have been posited as possible stem cell like
Externí odkaz:
https://doaj.org/article/798dcfd1d04e44b4aa17ab1120ac63b9
Autor:
Laura V Bownes, Adele P Williams, Raoud Marayati, Laura L Stafman, Hooper Markert, Colin H Quinn, Nikita Wadhwani, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0246244 (2021)
Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival. Enhancer of Zeste Homolog 2 (EZH2) is known to play a key role in supporting the m
Externí odkaz:
https://doaj.org/article/00f6cc5570544d52be7e472249944929
Autor:
Evan F. Garner, Adele P. Williams, Laura L. Stafman, Jamie M. Aye, Elizabeth Mroczek-Musulman, Blake P. Moore, Jerry E. Stewart, Gregory K. Friedman, Elizabeth A. Beierle
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Group 3 tumors account for 28% of medulloblastomas and have the worst prognosis. FTY720, an immunosuppressant currently approved for treatment of multiple sclerosis, has shown antitumor effects in several human cancer cell lines. We hypothes
Externí odkaz:
https://doaj.org/article/60d3b17a2b504ab498e8b0462588e830
Autor:
Laura L Stafman, Adele P Williams, Raoud Marayati, Jamie M Aye, Jerry E Stewart, Elizabeth Mroczek-Musulman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214469 (2019)
Despite an increase in incidence, treatments for hepatoblastoma remain virtually unchanged for the past 20 years, emphasizing the need for novel therapeutics. FTY720 (fingolimod) is an immunomodulator approved for use in multiple sclerosis in childre
Externí odkaz:
https://doaj.org/article/ca19d782775f4addb86b63daed0b25c9
Autor:
Alicia M. Waters, Laura L. Stafman, Evan F. Garner, Smitha Mruthyunjayappa, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle
Publikováno v:
Translational Oncology, Vol 9, Iss 4, Pp 263-273 (2016)
Despite the tremendous advances in the treatment of childhood solid tumors, rhabdomyosarcoma (RMS) continues to provide a therapeutic challenge. Children with metastatic or relapsed disease have a disease-free survival rate under 30%. Focal adhesion
Externí odkaz:
https://doaj.org/article/b5bd3aaff2064b53b27bfa1b1025c3f5
Autor:
Michael L Megison, Lauren A Gillory, Jerry E Stewart, Hugh C Nabers, Elizabeth Mroczek-Musulman, Alicia M Waters, Jennifer M Coleman, Virginia Kelly, James M Markert, G Yancey Gillespie, Gregory K Friedman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86843 (2014)
Recently, investigators showed that mice with syngeneic murine gliomas that were treated with a neuroattenuated oncolytic herpes simplex virus-1 (oHSV), M002, had a significant increase in survival. M002 has deletions in both copies of the γ134.5 ge
Externí odkaz:
https://doaj.org/article/cf72fe49647b4cb0863b5ccbf4674e7c
Autor:
Lauren A Gillory, Michael L Megison, Jerry E Stewart, Elizabeth Mroczek-Musulman, Hugh C Nabers, Alicia M Waters, Virginia Kelly, Jennifer M Coleman, James M Markert, G Yancey Gillespie, Gregory K Friedman, Elizabeth A Beierle
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77753 (2013)
Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric neural crest tumor, neuroblastoma, continues to be responsible for over 15% of pediatric cancer deaths. Novel therapeutic options are needed for this
Externí odkaz:
https://doaj.org/article/696aff62f7aa4201ace8f7313d31b1c0