Výsledky vyhledávání - "Elizabeth Millerman"

Akademický článek

Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.

Autor: Susan H Smith, Carlos E Peredo, Yukimasa Takeda, Thi Bui, Jessica Neil, David Rickard, Elizabeth Millerman, Jean-Philippe Therrien, Edwige Nicodeme, Jean-Marie Brusq, Veronique Birault, Fabrice Viviani, Hans Hofland, Anton M Jetten, Javier Cote-Sierra

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0147979 (2016)

Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, the stratum

Externí odkaz: https://doaj.org/article/eafec2826fc340719a00dd38c007ee18

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Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

Autor: David J. Rickard, Edwige Nicodeme, Jessica Neil, Javier Cote-Sierra, Véronique Birault, Anton M. Jetten, Susan H. Smith, Elizabeth Millerman, Thi Bui, Hans Hofland, Yukimasa Takeda, Fabrice Viviani, Jean-Marie Brusq, Jean-Philippe Therrien, Carlos E. Peredo

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0147979 (2016)

Background Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebff659de79b3a3b7f4a2c9d70b05aa
https://doi.org/10.1371/journal.pone.0147979

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ChemInform Abstract: Multiple Parallel Synthesis of N,N-Dialkyldipeptidylamines as N-Type Calcium Channel Blockers

Autor: Michael Francis Rafferty, Katalin Tarczy-Hornoch, Balazs G. Szoke, Lain-Yen Hu, Todd Robert Ryder, Elizabeth Millerman

Publikováno v: ChemInform. 30

Selective N-type Voltage Sensitive Calcium Channel (VSCC) blockers have shown utility in several models of stroke and pain. A series of N , N -dialkyldipeptidylamines with potent functional activity at N-type VSCC's has been identified. Multiple para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75452dadac3efbb072c9938c105f09e9
https://doi.org/10.1002/chin.199944207

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The discovery of [1-(4-dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethylbutyl)-phen yl]-(3-methyl-but-2-enyl)-amine, an N-type Ca+2 channel blocker with oral activity for analgesia

Autor: Susan M. Lotarski, Lain Yen Hu, Todd Robert Ryder, Balazs G. Szoke, M.Rose Feng, Charles Taylor, Michael Francis Rafferty, Elizabeth Millerman, Be Sheng Kuo, George P. Miljanich, Krista M. Siebers

Publikováno v: Bioorganicmedicinal chemistry. 8(6)

Our drug discovery efforts for N-type calcium channel blockers in the 4-piperidinylaniline series led to the discovery of an orally active analgesic agent 26.1-[4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethyl-but yl)-phenyl]-(3-methyl-but-2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e6f1bfcf79e5a6f819aeec3664caca
https://pubmed.ncbi.nlm.nih.gov/10896101

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Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties

Autor: G P Miljanich, Mark L. Weber, David M. Rock, B G Szoke, Lain-Yen Hu, Sally J. Stoehr, Todd Robert Ryder, Michael Sinz, Michael Francis Rafferty, Elizabeth Millerman, Yong-Xiang Wang, Susan M. Lotarski, S. Scott Bowersox, Charles Taylor, M R Feng

Publikováno v: Journal of medicinal chemistry. 42(20)

In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is described. N-Type VSCC blockers, such as ziconotide, have shown utility in several models o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5717d41b5b94e5d2230840d4c36c644a
https://pubmed.ncbi.nlm.nih.gov/10514294

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Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists

Autor: Elizabeth Millerman, Balazs G. Szoke, Susan M. Lotarski, Michael Francis Rafferty, David M. Rock, George P. Miljanich, Lain-Yen Hu, Todd Robert Ryder, Charles Taylor, Mark L. Weber, Sally J. Stoehr

Publikováno v: Bioorganicmedicinal chemistry letters. 9(16)

Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad06e5d10ff3d0b2e50572a570a5a53
https://pubmed.ncbi.nlm.nih.gov/10476886

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Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers

Autor: David J. Dooley, Charles Taylor, David M. Rock, Sally J. Stoehr, Lain-Yen Hu, George P. Miljanich, Elizabeth Millerman, Joann J. Geer, Susan M. Lotarski, Mark G. Vartanian, Balazs G. Szoke, Michael Francis Rafferty, R. Todd Ryder

Publikováno v: Bioorganicmedicinal chemistry letters. 9(15)

Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. In the process of searching for small molecule N-type calcium channel blockers, we have identified a series of N-methy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e325778df2c038aa46c8d2093a6fa49
https://pubmed.ncbi.nlm.nih.gov/10465535

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Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers

Autor: Balazs G. Szoke, Sham Shridhar Nikam, Elizabeth Millerman, Todd Robert Ryder, Lain-Yen Hu, Michael Francis Rafferty

Publikováno v: Bioorganicmedicinal chemistry letters. 9(8)

Selective N-type Voltage Activated Calcium Channel (VACC) blockers have shown utility in several models of stroke and pain. In the process of searching for small molecules as N-type calcium channel blockers, we have identified a series of N,N-dialkyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f07577f91d83e15ba150ba245a65963
https://pubmed.ncbi.nlm.nih.gov/10328297

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