Výsledky vyhledávání - "Elizabeth Medcalf"

Using epidemics to map H3 equine influenza virus determinants of antigenicity

Autor: Elizabeth Medcalf, Adam Rash, Alana Woodward, Debra Elton, Neil Bryant

Publikováno v: Virology. 481:187-198

Equine influenza is a major cause of respiratory infections in horses and causes widespread epidemics, despite the availability of commercial vaccines. Antigenic drift within the haemagglutinin (HA) glycoprotein is thought to play a part in vaccinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60689e53d0f128d52454c2953df0e5b1
https://doi.org/10.1016/j.virol.2015.02.027

Zobrazit plný text záznamu

Studies of an Influenza A Virus Temperature-Sensitive Mutant Identify a Late Role for NP in the Formation of Infectious Virions

Autor: Sarah L. Noton, John W. McCauley, Elizabeth Medcalf, Martha Simpson-Holley, Paul Digard, Edward C. Hutchinson, Helen M. Wise

Publikováno v: Noton, S L, Simpson-Holley, M, Medcalf, E, Wise, H M, Hutchinson, E C, McCauley, J W & Digard, P 2009, ' Studies of an Influenza A Virus Temperature-Sensitive Mutant Identify a Late Role for NP in the Formation of Infectious Virions ', Journal of Virology, vol. 83, no. 2, pp. 562-571 . https://doi.org/10.1128/jvi.01424-08

The influenza A virus nucleoprotein (NP) is a single-stranded RNA-binding protein that encapsidates the virus genome and has essential functions in viral-RNA synthesis. Here, we report the characterization of a temperature-sensitive ( ts ) NP mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527879a494771c6815fbe63b89282afe
https://doi.org/10.1128/jvi.01424-08

Zobrazit plný text záznamu

Interaction of the influenza virus nucleoprotein with F-actin

Autor: Elizabeth Medcalf, Martha Simpson-Holley, Paul Digard, Debra Elton

Publikováno v: International Congress Series. 1219:503-512

Introduction : The influenza virus genome is transcribed in the nucleus of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7bbe8ed3bd4f3641775a668f701811
https://doi.org/10.1016/s0531-5131(01)00628-8

Zobrazit plný text záznamu

The E1∧E4 Protein of Human Papillomavirus Type 16 Associates with a Putative RNA Helicase through Sequences in Its C Terminus

Autor: Elizabeth Medcalf, Simon N Stacey, Yohannes Mengistu, John Doorbar, Deborah J. Jackson, Ken Raj, Philip Masterson, Robert C. Elston, Julia Dunlop, Nicholas Coleman, Heather Griffin, Sawsan Napthine

Publikováno v: Journal of Virology. 74:10081-10095

Human papillomavirus type 16 (HPV16) infects cervical epithelium and is associated with the majority of cervical cancers. The E1∧E4 protein of HPV16 but not those of HPV1 or HPV6 was found to associate with a novel member of the DEAD box protein fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f8d1e159ac61c8ec628d03b0746e77
https://doi.org/10.1128/jvi.74.21.10081-10095.2000

Zobrazit plný text záznamu

Oligomerization of the Influenza Virus Nucleoprotein: Identification of Positive and Negative Sequence Elements

Autor: Debra Elton, Paul Digard, Elizabeth Medcalf, Konrad Bishop

Publikováno v: Elton, D, Medcalf, L, Bishop, K & Digard, P 1999, ' Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements ', Virology, vol. 260, no. 1, pp. 190-200 . https://doi.org/10.1006/viro.1999.9818

The RNA genome of influenza virus is encapsidated by the virus nucleoprotein (NP) to form ribonucleoprotein (RNP) structures of defined morphology. These structures result from the ability of NP to oligomerise and to bind single-strand RNA. To charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a33cb05d312a30f1dadcbee398f1a55

Zobrazit plný text záznamu

Isolation and characterisation of equine influenza viruses (H3N8) from Europe and North America from 2008 to 2009

Autor: Debra Elton, Ashish Tiwari, Franziska Wohlfender, Elizabeth Medcalf, Alana Woodward, Thomas M. Chambers, Maud Helwegen, Kerstin Borchers, Claudia Herrmann, Adam Rash, J. Richard Newton, Fatima Cruz, Neil Bryant, Jennifer A. Mumford

Publikováno v: Veterinary microbiology. 147(1-2)

Like other influenza A viruses, equine influenza virus undergoes antigenic drift. It is therefore essential that surveillance is carried out to ensure that recommended strains for inclusion in vaccines are kept up to date. Here we report antigenic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90505b4076a5c27e32895ad205d8913
https://pubmed.ncbi.nlm.nih.gov/20580170

Zobrazit plný text záznamu

Efficacy of a whole inactivated EI vaccine against a recent EIV outbreak isolate and comparative detection of virus shedding

Autor: Richard Newton, H. Barnes, Debra Elton, Elizabeth Medcalf, P. Trail, Romain Paillot, Martyn Jeggo, Fernando Montesso, James Watson, Neil Bryant, C. Donald, L. Prowse

Publikováno v: Veterinary immunology and immunopathology. 136(3-4)

An outbreak of H3N8 Equine Influenza virus (EIV) that occurred in vaccinated horses in Japan was caused by a genetically divergent EIV isolate of the Florida clade 1 sub-lineage. This virus subsequently entered Australia where it infected thousands o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77588c999a48599f7aa5a67163a4d054
https://pubmed.ncbi.nlm.nih.gov/20400185

Zobrazit plný text záznamu

Comparison of two modern vaccines and previous influenza infection against challenge with an equine influenza virus from the Australian 2007 outbreak

Autor: Julie Ross, Elizabeth Medcalf, Martyn Jeggo, Fernando Montesso, J. Richard Newton, Nicola S. Lewis, Debra Elton, James Watson, Adam Rash, Romain Paillot, Neil Bryant

Publikováno v: Veterinary Research
Veterinary Research, BioMed Central, 2010, 41 (2), ⟨10.1051/vetres/2009067⟩

International audience; During 2007, large outbreaks of equine influenza (EI) caused by Florida sublineage Clade 1 viruses affected horse populations in Japan and Australia. The likely protection that would be provided by two modern vaccines commerci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0745e96cf642b13b798de2f90c66381c
https://pubmed.ncbi.nlm.nih.gov/19863903

Zobrazit plný text záznamu

Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

Autor: Rosa M. Dalton, Maria João Amorim, Paul Digard, Anne E. Mullin, Laurence Tiley, Elizabeth Medcalf

Publikováno v: Dalton, R M, Mullin, A E, Amorim, M J, Medcalf, L, Tiley, L S & Digard, P 2006, ' Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes ', Virology Journal, vol. 3, no. 58 . https://doi.org/10.1186/1743-422X-3-58
Virology Journal, Vol 3, Iss 1, p 58 (2006)
Virology Journal

Background The RNA-dependent RNA polymerase of Influenza A virus is a determinant of viral pathogenicity and host range that is responsible for transcribing and replicating the negative sense segmented viral genome (vRNA). Transcription produces capp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5544409a1dc0d4449ec6428db39395da
https://www.pure.ed.ac.uk/ws/files/11478939/Temperature_sensitive_influenza_A_virus_genome_replication_results_from_low_thermal_stability_of_polymerase_cRNA_complexes.pdf

Zobrazit plný text záznamu

Modulation of Nuclear Localization of the Influenza Virus Nucleoprotein through Interaction with Actin Filaments

Autor: Konrad Bishop, Elizabeth Medcalf, Alan G. Weeds, Brian Pope, Paul Digard, Debra Elton

Publikováno v: Digard, P, Elton, D, Bishop, K, Medcalf, L, Weeds, A & Pope, B 1999, ' Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments ', Journal of Virology, vol. 73, no. 3, pp. 2222-31 .

The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145fd0f6fc5966d95ab79c4f13bf0d61
https://europepmc.org/articles/PMC104467/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání