Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Elizabeth Mazzio"'
1
Akademický článek
Plants against cancer: the immune-boosting herbal microbiome: not of the plant, but in the plant. Basic concepts, introduction, and future resource for vaccine adjuvant discovery
Autor: Elizabeth Mazzio, Andrew Barnes, Ramesh Badisa, Stevie Council, Karam F. A. Soliman
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
The presence of microorganism communities (MOCs) comprised of bacteria, fungi, archaea, algae, protozoa, viruses, and the like, are ubiquitous in all living tissue, including plant and animal. MOCs play a significant role in establishing innate and a
Externí odkaz: https://doaj.org/article/145959f416fa4fd8adcb466b08aab8cf
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2
Akademický článek
Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells
Autor: Ebony Nottingham, Elizabeth Mazzio, Sunil Kumar Surapaneni, Shallu Kutlehria, Arindam Mondal, Ramesh Badisa, Stephen Safe, Arun K. Rishi, Mandip Singh
Publikováno v: Journal of Pharmaceutical Analysis, Vol 11, Iss 6, Pp 799-807 (2021)
Non-small cell lung cancer (NSCLC) is often characterized by an underlying mutation in the epidermal growth factor receptor (EGFR), contributing to aggressive metastatic disease. Methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate (CDODA-Me), a
Externí odkaz: https://doaj.org/article/3aa7b7264fb1488ea63bccebb7902a3f
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3
Akademický článek
Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid
Autor: Elizabeth Mazzio, Nzinga Mack, Ramesh B. Badisa, Karam F. A. Soliman
Publikováno v: Biomolecules, Vol 11, Iss 12, p 1751 (2021)
A number of aggressive human malignant tumors are characterized by an intensified glycolytic rate, over-expression of lactic acid dehydrogenase A (LDHA), and subsequent lactate accumulation, all of which contribute toward an acidic peri-cellular immu
Externí odkaz: https://doaj.org/article/1fb09f8a29924425a1149f5a37d758c9
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4
Akademický článek
Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells.
Autor: David Bauer, Natalie Redmon, Elizabeth Mazzio, Karam F Soliman
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175558 (2017)
Mortality associated with breast cancer is attributable to aggressive metastasis, to which TNFα plays a central orchestrating role. TNFα acts on breast tumor TNF receptors evoking the release of chemotactic proteins (e.g. MCP-1/CCL2). These protein
Externí odkaz: https://doaj.org/article/88c6ba4c49bc40198a779d5edd432491
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5
Akademický článek
N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells.
Autor: Ramesh B Badisa, Sanjay S Kumar, Elizabeth Mazzio, Rasheda D Haughbrook, John R Allen, Michael W Davidson, Cheryl A Fitch-Pye, Carl B Goodman
Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0114285 (2015)
Cocaine has a short half-life of only about an hour but its effects, predominantly on the central nervous system (CNS), are fairly long-lasting. Of all cells within the CNS, astrocytes may be the first to display cocaine toxicity owing to their relat
Externí odkaz: https://doaj.org/article/1779d78db14c406dbb7059a0ebbdbd85
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7
Abstract 3834: Antiproliferative activity of substituted chromone-2-carboxamides on MDA-MB-231 cells and their 3D pharmacophore models
Autor: Kinfe Ken Redda, Madhavi Gangapuram, Suresh Eyunni, Elizabeth Mazzio, Karam F. A. Soliman
Publikováno v: Cancer Research. 83:3834-3834
After lung cancer, breast cancer is the second leading cause of cancer death in women in the United States, accounting for 12.5 % of all new cancer cases globally. Triple-negative breast cancer (TNBC) remains the hardest breast cancer and is difficul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1479c422ed3e4141ca2ff238371267bf
https://doi.org/10.1158/1538-7445.am2023-3834
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8
Metabolic Response to the Mitochondrial Toxin 1-Methyl-4-phenylpyridinium (MPP+) in LDH-A/B Double-knockout LS174T Colon Cancer Cells
Autor: Elizabeth Mazzio, Karam F.A. Soliman, Nzinga Mack, Ramesh B. Badisa
Publikováno v: Cancer Genomics Proteomics
Background/Aim: Rapid glycolytic substrate-level phosphorylation (SLP) and accumulation of lactic acid are characteristics of diverse cancers. Recent advances in drug discovery have included the use of glycolytic inhibitors with mitochondrial targeti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff1b6f4fefeea9fa86256a9627016ae
https://doi.org/10.21873/cgp.20267
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9
Effects of Wild Yam Root (Dioscorea villosa) Extract on the Gene Expression Profile of Triple-negative Breast Cancer Cells
Autor: Abdulaziz Almalki, Karam F.A. Soliman, Elizabeth Mazzio, Selina Darling-Reed
Publikováno v: Cancer Genomics Proteomics
Background/aim Wild yam extract [Dioscorea villosa, (WYE)] is consistently lethal at low IC50s across diverse cancer-lines in vitro. Unlike traditional anti-cancer botanicals, WYE contains detergent saponins which reduce oil-water interfacial tension
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147f1ff44dec7f4620fd80bdd4013bd
https://doi.org/10.21873/cgp.20294
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