Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Elizabeth M. Topp"'
Autor:
Ahmed Abdelraheem, Rishabh Tukra, Petr Kazarin, Michael D Sinanis, Elizabeth M Topp, Alina Alexeenko, Dimitrios Peroulis
Publikováno v:
PNAS Nexus. 1
Lyophilization is a common unit operation in pharmaceutical manufacturing but is a prolonged vacuum drying process with poor energy utilization. Microwave-assisted vacuum drying has been investigated to accelerate the lyophilization process. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326a6b4e0b06c769a84e4a10007ca95e
https://doi.org/10.1093/pnasnexus/pgac052
https://doi.org/10.1093/pnasnexus/pgac052
Autor:
Rajashekar Kammari, Elizabeth M. Topp
Publikováno v:
Molecular Pharmaceutics. 17:3541-3552
The reversibility of solid-state hydrogen-deuterium exchange (ssHDX) and the effects of prehydration on the rate and extent of deuterium incorporation were evaluated using poly-d,l-alanine (PDLA) peptides colyophilized with various excipients. In pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42167dd3dec24b8220b92ad6b4e179a9
https://doi.org/10.1021/acs.molpharmaceut.0c00571
https://doi.org/10.1021/acs.molpharmaceut.0c00571
Autor:
Alina Alexeenko, Elizabeth M. Topp
Publikováno v:
Drying Technologies for Biotechnology and Pharmaceutical Applications. :355-372
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6654fd09823c4733eb9b78c932dfcff4
https://doi.org/10.1002/9783527802104.ch15
https://doi.org/10.1002/9783527802104.ch15
Autor:
Yuan Chen, Elizabeth M. Topp
Publikováno v:
Journal of Pharmaceutical Sciences. 109:709-718
Excipients used in lyophilized protein drug products are often selected by a trial-and-error method, in part, because the analytical methods used to detect protein-excipient interactions in lyophilized solids are limited. In this study, photolytic la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d5f1a02cba1678b9abfdb2d541967d
https://doi.org/10.1016/j.xphs.2019.04.024
https://doi.org/10.1016/j.xphs.2019.04.024
Publikováno v:
Molecular pharmaceutics. 18(8)
N-terminal glutamate can cyclize to form pyroglutamate (pGlu) in pharmaceutically relevant peptides and proteins. The reaction occurs nonenzymatically during storage for monoclonal antibodies and shows a strong 'pH' dependence in solution, but the so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d94913a4c89b6e637c8005076c6aa5b
https://pubmed.ncbi.nlm.nih.gov/34232660
https://pubmed.ncbi.nlm.nih.gov/34232660
Autor:
Elizabeth M. Topp, Jing Ling, Lynne S. Taylor, Mingyue Li, Yongchao Su, Tarun Tejasvi Mutukuri, Eric J. Munson, Qi Tony Zhou, Yuan Chen, Kinnari Santosh Arte
Publikováno v:
Mol Pharm
Mannitol, leucine and trehalose have been widely used in spray-dried formulations, especially for inhalation formulations. The individual contribution of these excipients on protein physical stability in spray-dried solids were studied here using bov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe08edf41c612b3f1705d9c7b7c85ccf
https://pubmed.ncbi.nlm.nih.gov/34096731
https://pubmed.ncbi.nlm.nih.gov/34096731
Autor:
Yuan Chen, Elizabeth M. Topp
Publikováno v:
Journal of Pharmaceutical Sciences. 108:791-797
In this mini-review, the major types of photolytic labeling reagents are presented together with their reaction mechanisms. The applications of photolytic labeling in protein drug discovery and development are then discussed; these have expanded from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b4c999c0d9e33c7d01cd54d2fa930c
https://doi.org/10.1016/j.xphs.2018.10.017
https://doi.org/10.1016/j.xphs.2018.10.017
Autor:
Brendan M. Mayhugh, Elizabeth M. Topp, Eunbi Cho, Gregory A. Sacha, Jayasree M. Srinivasan, Steven L. Nail
Publikováno v:
Journal of Pharmaceutical Sciences.
Antibody drug conjugates (ADCs) have been at the forefront in cancer therapy due to their target specificity. All the FDA approved ADCs are developed in lyophilized form to minimize instability associated with the linker that connects the cytotoxic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236e224940b29066e99c2f9d084c3639
https://doi.org/10.1016/j.xphs.2021.03.006
https://doi.org/10.1016/j.xphs.2021.03.006
Autor:
Elizabeth M. Topp, Rajashekar Kammari
Publikováno v:
Molecular pharmaceutics. 17(9)
The effects of peptide secondary structure on the rate and extent of deuterium incorporation in solid-state hydrogen deuterium exchange mass spectrometry (ssHDX-MS) were assessed. Unstructured poly-d,l-alanine (PDLA) peptides, an α-helical model pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbe0e38a3f5164adec040f58b97ace0
https://pubmed.ncbi.nlm.nih.gov/32672982
https://pubmed.ncbi.nlm.nih.gov/32672982
Autor:
Qi Tony Zhou, Lynne S. Taylor, Elizabeth M. Topp, Nathan E. Wilson, Dmitry Zemlyanov, Tarun Tejasvi Mutukuri
Publikováno v:
Pharm Res
PURPOSE: The aim of this study is to determine the effects of saccharide-containing excipients on the surface composition of spray-dried protein formulations and their matrix heterogeneity. METHODS: Spray-dried formulations of myoglobin or bovine ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200e4f8e5c37f251de984ee72345bd66
https://doi.org/10.1007/s11095-019-2738-9
https://doi.org/10.1007/s11095-019-2738-9