Výsledky vyhledávání - "Elizabeth M. Repash"

Akademický článek

Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators

Autor: Elizabeth M. Repash, Kaitlin M. Pensabene, Peter M. Palenchar, Aimee L. Eggler

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Multi-drug combination therapy carries significant promise for pharmacological intervention, primarily better efficacy with less toxicity and fewer side effects. However, the field lacks methodology to assess synergistic or antagonistic interactions

Externí odkaz: https://doaj.org/article/f4501d430b854b3b8afbcaa03d0b7357

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Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators

Autor: Kaitlin M Pensabene, Aimee L. Eggler, Elizabeth M Repash, Peter M. Palenchar

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b6f9264175725611344fef22f44065
https://www.frontiersin.org/articles/10.3389/fphar.2021.686201/full

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Quantifying synergy for hormetic compounds using the dose-equivalence/zero-interaction (DE/ZI) method: Nrf2/antioxidant response element pathway activation

Autor: Elizabeth M Repash, Aimee L. Eggler, Peter M. Palenchar

Publikováno v: Free Radical Biology and Medicine. 128:S119

Small molecule Nrf2/ARE pathway activators show promise to preventchronic disease conditions, given their role in mitigating oxidative and electrophilic stress. We find that the efficacy and potency of the clinically-studied electrophilic Nrf2/ARE ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cddbf534b53a6015edb2eab5ece9a56
https://doi.org/10.1016/j.freeradbiomed.2018.10.292

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Akademický článek

Solving the Problem of Assessing Synergy and Antagonism for Non-Traditional Dosing Curve Compounds Using the DE/ZI Method: Application to Nrf2 Activators.

Autor: Repash, Elizabeth M., Pensabene, Kaitlin M., Palenchar, Peter M., Eggler, Aimee L.

Publikováno v: Frontiers in Pharmacology; 6/7/2021, Vol. 12, p1-14, 14p

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Abstract PO077: BT7480, a novel fully synthetic tumor-targeted immune cell agonist (TICA™) induces tumor localized 4-1BB agonism

Autor: Marianna Kleyman, Jun Ma, Kevin Mcdonnell, Philip Brandish, Sailaja Battula, Johanna Lahdenranta, Punit Upadhyaya, Elizabeth Repash, Eric Haines, Nicholas Keen, Kristen Hurov, Liuhong Chen, Jessica Kublin

Publikováno v: Cancer Immunology Research. 9:PO077-PO077

Harnessing costimulatory molecules expressed on T and NK cells namely 4-1BB (CD137/TNFRSF9) is ideal for cancer immunotherapy. Despite promise preclinically, 4-1BB agonistic antibodies, were unable to demarcate hepatoxicity from efficacy in the clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b84741692db9ff257ff84f0606f14f6
https://doi.org/10.1158/2326-6074.tumimm20-po077

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