Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Elizabeth M. Perez"'
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
We possess rather little detailed information on the lives of the first inhabitants of Puerto Rico—the so-called “Archaic” or “Pre-Arawak” people—despite more than a century of archeological research. This is particularly true bioarchaeol
Externí odkaz:
https://doaj.org/article/cccf511864474c8283d42d31ba4ee219
Autor:
Robert T. Lawrence, Elizabeth M. Perez, Daniel Hernández, Chris P. Miller, Kelsey M. Haas, Hanna Y. Irie, Su-In Lee, C. Anthony Blau, Judit Villén
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 630-644 (2015)
Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical outcomes and a shortage of targeted treatment options. To discover molecular features of triple-negative breast cancer, we performed quantitative proteomics analy
Externí odkaz:
https://doaj.org/article/b77b8a1f878c45758aa622ed53bbe73c
Autor:
Giulia Notarangelo, Jessica B. Spinelli, Elizabeth M. Perez, Gregory J. Baker, Kiran Kurmi, Ilaria Elia, Sylwia A. Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J. Golby, Shakchhi Joshi, Heide F. Baron, Jefte M. Drijvers, Peter Georgiev, Alison E. Ringel, Elma Zaganjor, Samuel K. McBrayer, Peter K. Sorger, Arlene H. Sharpe, Kai W. Wucherpfennig, Sandro Santagata, Nathalie Y. R. Agar, Mario L. Suvà, Marcia C. Haigis
Publikováno v:
Science
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the production of d -2-hydroxyglutarate ( d -2HG), an oncometabolite that promotes tumorigenesis through epigenetic alterations. The cancer cell–intrinsic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7a58c7c475f20ec0bb7e357a802a07
https://pubmed.ncbi.nlm.nih.gov/36173838
https://pubmed.ncbi.nlm.nih.gov/36173838
Autor:
Meenal Datta, Sampurna Chatterjee, Elizabeth M. Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X. Chen, Kamila Naxerova, Ashwin S. Kumar, Mitrajit Ghosh, Kyrre E. Emblem, Mei R. Ng, William W. Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C. Speranza, Martha R. Neagu, David A. Reardon, Arlene H. Sharpe, Gordon J. Freeman, Mario L. Suvà, Lei Xu, Rakesh K. Jain
Immune checkpoint blockers (ICBs) have failed in all Phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice with glioblastoma. Through single-cell RNA sequencing, intravital imaging, and T cell blockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6474488349a3ee36820acad414ac747
https://doi.org/10.1101/2022.06.28.497997
https://doi.org/10.1101/2022.06.28.497997
Autor:
Raffaele Renella, Tugba Keskin, Mario L. Suvà, Manuel Diezi, Stéphane Cherix, Liliane C. Broye, Igor Letovanec, Stefano La Rosa, Paolo Provero, Ivan Stamenkovic, Elizabeth M. Perez, Beatrice Rucci, Patricia Martin, Carlo Fusco, Sandrine Cornaz-Buros, Nicolo Riggi, Katarina Cisarova
Publikováno v:
Science advances, vol. 7, no. 27, pp. eabf9394
Targeting of the most aggressive tumor cell subpopulations is key for effective management of most solid malignancies. However, the metastable nature of tumor heterogeneity, which allows cells to transition between strong and weak tumorigenic phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ce34667ed8f5eb29b801a9dab6afe5
https://pubmed.ncbi.nlm.nih.gov/34215585
https://pubmed.ncbi.nlm.nih.gov/34215585
Autor:
Mario Suva, Kai Wucherpfennig, David A. Reardon, Simon Gritsch, Elizabeth M. Perez, Aviv Regev, Sascha Marx, Orr Ashenberg, Nathan Mathewson
Publikováno v:
Neuro-Oncology Advances. 3:ii15-ii15
T-cells are critical effector cells of cancer immunotherapies, but little is known about T-cell gene expression programs in diffuse gliomas. We leveraged single-cell RNA-seq to chart the gene expression and clonal landscape of tumor-infiltrating T-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a7c930ce88a4c1a020935345b36356
https://doi.org/10.1093/noajnl/vdab070.059
https://doi.org/10.1093/noajnl/vdab070.059
Publikováno v:
Oncotarget
Previous Epstein-Barr virus (EBV) prophylactic vaccines based on the major surface glycoprotein gp350/220 as an immunogen have failed to block viral infection in humans, suggesting a need to target other viral envelope glycoproteins. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07c18f9322010fc5de6e7cd26264386
https://doi.org/10.18632/oncotarget.13770
https://doi.org/10.18632/oncotarget.13770
Autor:
Matthew P. Frosch, Orr Ashenberg, Mirco Friedrich, Hiroaki Wakimoto, Heather L. Cahill, Prafulla C. Gokhale, Gordon J. Freeman, Jason Pyrdol, X. Shirley Liu, Kai W. Wucherpfennig, Priscilla K. Brastianos, Rony Chanoch-Myers, Michael J. Poitras, Daniel P. Cahill, Itay Tirosh, David A. Reardon, Marni E. Shore, Wubing Zhang, Olamide Olawoyin, L. Nicolas Gonzalez Castro, Yoshinaga Ito, Nathan Mathewson, Simon Gritsch, David N. Louis, Toshiro Hara, Pamela S. Jones, Alexander Marson, Orit Rozenblatt-Rosen, Keith L. Ligon, Livnat Jerby-Arnon, E. Antonio Chiocca, Aviv Regev, Christine M. Hebert, Sascha Marx, Matthew Drummond, Alyssa R. Richman, Brian A. Shaw, Kathrin Schumann, Elizabeth M. Perez, Mario L. Suvà
Publikováno v:
Cell. 184(5)
Summary T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-seq) to chart the gene expression and clonal landscape of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4b267468acc6e98c731dad13fcecea
https://pubmed.ncbi.nlm.nih.gov/33811061
https://pubmed.ncbi.nlm.nih.gov/33811061
Autor:
Daniel P. Cahill, Tracy T. Batchelor, Priscilla K. Brastianos, William T. Curry, Orit Rozenblatt-Rosen, Dennis M. Bonal, John M. DeWitt, Ivan Stamenkovic, Anoop P. Patel, Inder M. Verma, Irene Slavc, Aviv Regev, Ravindra Mylvaganam, René Geyeregger, Mario L. Suvà, Christine M. Hebert, Anat Stemmer-Rachamimov, Julia L. Small, Lisa Mayr, Nicholas Druck, Alexander Kaplan, Simon Gritsch, Sarah Becker, L. Nicolas Gonzalez Castro, David N. Louis, Toshiro Hara, Danielle Dionne, Brian V. Nahed, Rachel L. Servis, Xiaoyang Lan, McKenzie Shaw, Keith L. Ligon, Cyril Neftel, Christopher Rodman, Kristine Pelton, Johannes Gojo, Mariella G. Filbin, Matthew P. Frosch, Esther Rheinbay, Tony Hunter, Michelle Monje, Marni E. Shore, Dana Silverbush, Elizabeth M. Perez, Gilbert J. Rahme, Hiroaki Wakimoto, Jeremy M. Fung, Quang-Dé Nguyen, Itay Tirosh, Maria Martinez-Lage, Julie Laffy, Alyssa R. Richman, Mia Bertalan, Thomas Czech, Christine Haberler, Bradley E. Bernstein, Nicolo Riggi, Bob S. Carter
Publikováno v:
Cell
PMC
PMC
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, we use an integrative approach spanning single-cell RNA-sequencing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85367a06752131d82809bde947d45b2f
https://europepmc.org/articles/PMC6703186/
https://europepmc.org/articles/PMC6703186/
Autor:
Sharon R. Grossman, Glen Munson, Joseph Nasser, Drew T. Bergman, Elizabeth M. Perez, Michael Kane, Elena K. Stamenova, Benjamin R. Doughty, Thouis R. Jones, Charles P. Fulco, Rockwell Anyoha, Eric S. Lander, Neva C. Durand, Tung T. Nguyen, Tejal A. Patwardhan, Vidya Subramanian, Jesse M. Engreitz, Erez Lieberman Aiden
Mammalian genomes harbor millions of noncoding elements called enhancers that quantitatively regulate gene expression, but it remains unclear which enhancers regulate which genes. Here we describe an experimental approach, based on CRISPR interferenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a9c53caf034ef390045c07f233f26d
https://doi.org/10.1101/529990
https://doi.org/10.1101/529990