miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

Autor: Paul N. Valdmanis, Hak Kyun Kim, Kirk Chu, Feijie Zhang, Jianpeng Xu, Elizabeth M. Munding, Jia Shen, Mark A. Kay

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

miR-122 is a highly expressed microRNA in the liver. Here the authors analyse the mouse liver microRNA landscape following depletion of miR-122 and the impact that this has on its target mRNAs.

Externí odkaz: https://doaj.org/article/bce2ee1a64f046a383d8e6d4a3be7c1a

Loss of Epigenetic Information as a Cause of Mammalian Aging

Autor: Brendan O'Connell, Xiaojing Yang, Jaime M. Ross, Yuancheng Lu, Jonathan G. Seidman, Mital Bhakta, Amy J. Wagers, João A. Amorim, Qiao Su, Bruce R. Ksander, Jae-Hyun Yang, Jill A. Kreiling, Elias L. Salfati, Stuart J. Shankland, Richard E. Green, Christine E. Seidman, Ana-Maria Balta, Andreas R. Pfenning, George F. Murphy, Michael Bonkowski, Benjamin A. Garcia, Luis A. Rajman, Patrick Griffin, Marco Blanchette, Yasuaki Mohri, Meghan A. Rego, Sarah J. Mitchell, Meredith S Gregory-Ksander, Kazuo Tsubota, Sachin Thakur, Raul Mostoslavsky, Caiyue Xu, Hiroko Wakimoto, John M. Sedivy, Norman S. Wolf, Philipp Oberdoerffer, Yap Ching Chew, John K. Apostolides, Alice E. Kane, Michael L. Creswell, Laura Schaevitz, Motoshi Hayano, Zhixun Dou, Margarita V. Meer, Giuseppe Coppotelli, Elizabeth M. Munding, Xiao Tian, Carlos M. Palmeira, Wei Guo, Shelley L. Berger, Tatjana C. Jakobs, Daniel L. Vera, Emi K. Nishimura, Lei Zhong, David A. Sinclair, Abhirup Das, Jeffrey W. Pippin, Vadim N. Gladyshev, Stephen J. Bonasera, Neha Garg

Publikováno v: SSRN Electronic Journal.

All living things experience entropy, manifested as a loss of inherited genetic and epigenetic information over time. In yeast, epigenetic changes result in a loss of cell identity and sterility, both hallmarks of yeast aging. In mammals, epigenetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::245f07f1a3ddd3b145824aa1a6d8802f
https://doi.org/10.2139/ssrn.3951490

Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome

Autor: Robert Shelansky, Jason Talkish, Elizabeth M. Munding, Sol Katzman, Lily Shiue, Rhonda J. Perriman, Haller Igel, John Paul Donohue, Manuel Ares

Publikováno v: PLoS Genetics, Vol 15, Iss 8, p e1008249 (2019)
PLoS genetics, vol 15, iss 8
PLoS Genetics

Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs) glo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af59a5aef74ee9ba816b4e5d33d3f90c
https://doaj.org/article/bb1bc818d7cc45c9ab1f236047b04be5

RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice

Autor: Huban Kutay, Yong Huang, Paul N. Valdmanis, Mark A. Kay, Kirk Chu, Kalpana Ghoshal, Elizabeth M. Munding, Leszek Lisowski, Feijie Zhang, Yue Zhang, Lan Jin, Shuo Gu

Publikováno v: Nature Medicine. 22:557-562

Small RNAs can be engineered to target and eliminate expression of disease-causing genes or infectious viruses, resulting in the preclinical and clinical development of RNA interference (RNAi) therapeutics using these small RNAs. To ensure the succes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::550a7cc2629136100a2730ca978c20a9
https://doi.org/10.1038/nm.4079

Competition between Pre-mRNAs for the splicing machinery drives global regulation of splicing

Autor: Elizabeth M. Munding, Sol Katzman, John Paul Donohue, Manuel Ares, Lily Shiue

Publikováno v: Munding, EM; Shiue, L; Katzman, S; Donohue, JP; & Ares, M. (2013). Competition between Pre-mRNAs for the splicing machinery drives global regulation of splicing. Molecular Cell, 51(3), 338-348. doi: 10.1016/j.molcel.2013.06.012. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/4h28r6r9
Molecular cell, vol 51, iss 3

During meiosis in yeast, global splicing efficiency increases and then decreases. Here we provide evidence that splicing improves due to reduced competition for the splicing machinery. The timing of this regulation corresponds to repression and react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2e14b757d926b55c9d83659e244bab
http://www.escholarship.org/uc/item/4h28r6r9