Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elizabeth M. Leaf"'
Autor:
Jimin Lee, Cameron Stewart, Alexandra Schäfer, Elizabeth M. Leaf, Young-Jun Park, Daniel Asarnow, John M. Powers, Catherine Treichel, Kaitlin R. Sprouse, Davide Corti, Ralph Baric, Neil P. King, David Veesler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a v
Externí odkaz:
https://doaj.org/article/780e43f46b0341b2b056a3f52e383c25
Autor:
Subramanian Dharmarajan, Mei Y. Speer, Kate Pierce, Jake Lally, Elizabeth M. Leaf, Mu-En Lin, Marta Scatena, Cecilia M. Giachelli
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification. Combine
Externí odkaz:
https://doaj.org/article/3bbcae9c41154eefb33daa442b24a944
Autor:
Isaac D. Lutz, Shunzhi Wang, Christoffer Norn, Alexis Courbet, Andrew J. Borst, Yan Ting Zhao, Annie Dosey, Longxing Cao, Jinwei Xu, Elizabeth M. Leaf, Catherine Treichel, Patrisia Litvicov, Zhe Li, Alexander D. Goodson, Paula Rivera-Sánchez, Ana-Maria Bratovianu, Minkyung Baek, Neil P. King, Hannele Ruohola-Baker, David Baker
Publikováno v:
Science. 380:266-273
As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approa
Autor:
Marta Scatena, Jake Lally, Cecilia M. Giachelli, Mu-En Lin, Elizabeth M. Leaf, Mei Y. Speer, Subramanian Dharmarajan, Kate Pierce
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Background: Calcific aortic valve disease is common in the aging population and is characterized by the histological changes of the aortic valves including extracellular matrix remodeling, osteochondrogenic differentiation, and calcification. Combine
Autor:
Mary C. Wallingford, Elizabeth M. Leaf, Cecilia M. Giachelli, Susan M Lund, Kadin E Brooks, Nicholas W. Chavkin
Publikováno v:
J Vasc Res
The sodium-dependent phosphate transporter, SLC20A1, is required for elevated inorganic phosphate (Pi) induced vascular smooth muscle cell (VSMC) matrix mineralization and phenotype transdifferentiation. Recently, elevated Pi was shown to induce ERK1
Autor:
Brandon McLeod, Moustafa T. Mabrouk, Kazutoyo Miura, Rashmi Ravichandran, Sally Kephart, Sophia Hailemariam, Thao P. Pham, Anthony Semesi, Iga Kucharska, Prasun Kundu, Wei-Chiao Huang, Max Johnson, Alyssa Blackstone, Deleah Pettie, Michael Murphy, John C. Kraft, Elizabeth M. Leaf, Yang Jiao, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Jordache Ramjith, C. Richter King, Randall S. MacGill, Yimin Wu, Kelly K. Lee, Matthijs M. Jore, Neil P. King, Jonathan F. Lovell, Jean-Philippe Julien
Publikováno v:
Immunity, 55, 1680-1692.e8
Immunity, 55, 9, pp. 1680-1692.e8
Immunity, 55, 9, pp. 1680-1692.e8
Contains fulltext : 283288.pdf (Publisher’s version ) (Open Access) Malaria transmission-blocking vaccines (TBVs) aim to elicit human antibodies that inhibit sporogonic development of Plasmodium falciparum in mosquitoes, thereby preventing onward t
Autor:
Marta Scatena, Elizabeth M. Leaf, Cecilia M. Giachelli, Melissa F. Jackson, Mary C. Wallingford, Mei Y. Speer
Publikováno v:
Cardiovascular Pathology. 34:28-37
Objective Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis (AS) and cardiac insufficiency. Patients with type II diabetes mellitus (T2DM) are at heightened risk for CAVD, and their valves have greater calcification than nondia
Autor:
Cecilia M. Giachelli, Hai Zhang, Apichai Yavirach, Elizabeth M. Leaf, Marta Scatena, Jonathan Y. An, Worakanya Buranaphatthana
Publikováno v:
Bone
Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of antiresorptive medications such as denosumab (humanized anti-RANKL antibody), yet its pathophysiology remains elusive. It has been posited that inhibition of osteoclastic
Autor:
Cecilia M. Giachelli, Suhaib Borgeia, Mary C. Wallingford, Timothy C. Cox, Chenphop Sawangmake, Jia Jun Chia, Elizabeth M. Leaf, Kenneth I. Marro, Nicholas W. Chavkin, Mei Y. Speer
Publikováno v:
Brain Pathology. 27:64-76
Idiopathic basal ganglia calcification is a brain calcification disorder that has been genetically linked to autosomal dominant mutations in the sodium-dependent phosphate co-transporter, SLC20A2. The mechanisms whereby deficiency of Slc20a2 leads to
Publikováno v:
The American Journal of Pathology. 185:1958-1969
Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common feature of AMC, and is preceded by expression of runt-related transcription f