Zobrazeno 1 - 10
of 648
pro vyhledávání: '"Elizabeth M. Jaffee"'
Autor:
Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity i
Externí odkaz:
https://doaj.org/article/098a7d924d184c9b829632f226e3bd36
Autor:
Sahana Jayaraman, Janelle M. Montagne, Thomas R. Nirschl, Emily Marcisak, Jeanette Johnson, Amanda Huff, Meng-Hsuan Hsiao, Julie Nauroth, Thatcher Heumann, Jelani C. Zarif, Elizabeth M. Jaffee, Nilo Azad, Elana J. Fertig, Neeha Zaidi, H. Benjamin Larman
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100600- (2023)
Summary: Assays linking cellular phenotypes with T cell or B cell antigen receptor sequences are crucial for characterizing adaptive immune responses. Existing methodologies are limited by low sample throughput and high cost. Here, we present INtraCE
Externí odkaz:
https://doaj.org/article/45d70b67a0e84bbe9759acdd360e9fa1
Autor:
George J. Xu, Matthew A. Loberg, Jean-Nicolas Gallant, Quanhu Sheng, Sheau-Chiann Chen, Brian D. Lehmann, Sophia M. Shaddy, Megan L. Tigue, Courtney J. Phifer, Li Wang, Mario W. Saab-Chalhoub, Lauren M. Dehan, Qiang Wei, Rui Chen, Bingshan Li, Christine Y. Kim, Donna C. Ferguson, James L. Netterville, Sarah L. Rohde, Carmen C. Solórzano, Lindsay A. Bischoff, Naira Baregamian, Aaron C. Shaver, Mitra Mehrad, Kim A. Ely, Daniel W. Byrne, Thomas P. Stricker, Barbara A. Murphy, Jennifer H. Choe, Luciane T. Kagohara, Elizabeth M. Jaffee, Eric C. Huang, Fei Ye, Ethan Lee, Vivian L. Weiss
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100409- (2023)
Summary: Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging and histology, with few molecular prognostic and treatment biomarkers. Here, we utilize a large c
Externí odkaz:
https://doaj.org/article/fc1b6ef5686b46cf86fe3857f3b602c5
Autor:
Eric S. Christenson, Valerie Lee, Hao Wang, Mark Yarchoan, Ana De Jesus-Acosta, Nilo Azad, Ahmet Gurakar, Ming-Tseh Lin, Dung T. Le, Daniel C. Brennan, Elizabeth M. Jaffee, Katherine Bever
Publikováno v:
Current Oncology, Vol 30, Iss 1, Pp 75-84 (2022)
Solid organ transplants are associated with a modestly increased risk of colorectal cancers (CRC). However, the molecular profile of these cancers has not been described. We hypothesized that transplant-related immunosuppression may promote developme
Externí odkaz:
https://doaj.org/article/b110dfb63cd44b4ba2e832db24cc3f56
Autor:
Eric S. Christenson, Hua-Ling Tsai, Dung T. Le, Elizabeth M. Jaffee, Jonathan Dudley, Rena R. Xian, Christopher D. Gocke, James R. Eshleman, Ming-Tseh Lin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe highest incidence of colorectal cancer (CRC) is in patients diagnosed at 80 years or older highlighting a need for understanding the clinical and molecular features of these tumors. Methods. In this retrospective cohort study, 544 CRC
Externí odkaz:
https://doaj.org/article/8841049f59e041529a1006b1a22e697f
Autor:
Emily F. Davis-Marcisak, Allison A. Fitzgerald, Michael D. Kessler, Ludmila Danilova, Elizabeth M. Jaffee, Neeha Zaidi, Louis M. Weiner, Elana J. Fertig
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Tumor response to therapy is affected by both the cell types and the cell states present in the tumor microenvironment. This is true for many cancer treatments, including immune checkpoint inhibitors (ICIs). While it is well-estab
Externí odkaz:
https://doaj.org/article/80075777f0424f8d9407c33875af4fe0
Autor:
Dimitrios N. Sidiropoulos, Genevieve L. Stein-O’Brien, Ludmila Danilova, Nicole E. Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Hao Wang, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Mass cytometry, or cytometry by TOF (CyTOF), provides a robust means of determining protein-level measurements of more than 40 markers simultaneously. While the functional states of immune cells occur along continuous phenotypic transitions, cytometr
Externí odkaz:
https://doaj.org/article/16cb3e58e1f7450682ee64a8668cb44a
Autor:
Won Jin Ho, Rossin Erbe, Ludmila Danilova, Zaw Phyo, Emma Bigelow, Genevieve Stein-O’Brien, Dwayne L. Thomas, Soren Charmsaz, Nicole Gross, Skylar Woolman, Kayla Cruz, Rebecca M. Munday, Neeha Zaidi, Todd D. Armstrong, Marcelo B. Sztein, Mark Yarchoan, Elizabeth D. Thompson, Elizabeth M. Jaffee, Elana J. Fertig
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Background The majority of pancreatic ductal adenocarcinomas (PDAC) are diagnosed at the metastatic stage, and standard therapies have limited activity with a dismal 5-year survival rate of only 8%. The liver and lung are the most common sit
Externí odkaz:
https://doaj.org/article/4cd9bd7ed8eb40259c3e0e809f852646
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
The COVID-19 pandemic has elevated mRNA vaccines to global recognition due to their unprecedented success rate in protecting against a deadly virus. This international success is underscored by the remarkable versatility, favorable immunogenicity, an
Externí odkaz:
https://doaj.org/article/8eb773cdff2e47a6b6e25cd27c64f576
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to low therapeutic response rates and poor prognoses. Majority of patients present with symptoms post metastatic spread, which contributes to its overall lethality as th
Externí odkaz:
https://doaj.org/article/8fbdea4367b240f496e4f6ddb4f33b2a