Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elizabeth M. Horstman"'
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 12, Pp 1714-1717 (2016)
A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-hydroxy-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzothiazine-3-carboxamide–2-(4-oxido-1,1-dioxo-2H-1λ6,2-benzothiazine-3-amido)pyridin-1-ium–2,5-dihydroxybenzoic acid, 2C15H13
Externí odkaz:
https://doaj.org/article/79d612aed0064563a5b9fdd83c6e8779
Autor:
Sean Ritchie, Michael J. Geier, Philippa Payne, Remus Osan, Elizabeth M. Horstman, Henry Morrison, Ernest Lee, Mark E. Scott, Xiaotian Wang
Publikováno v:
Organic Process Research & Development. 25:1036-1046
Presented herein is an approach for correlating active pharmaceutical ingredient (API) bulk properties such as particle size, surface area, powder flow, morphology, and dissolution in order to prov...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370bba6d1d111433ac2db3219c9cf5eb
https://doi.org/10.1021/acs.oprd.1c00043
https://doi.org/10.1021/acs.oprd.1c00043
Publikováno v:
Organic Process Research & Development. 22:1432-1440
GS-X and GS-Y are novel active pharmaceutical ingredients (APIs) selected for early clinical development. For each API, two slightly hygroscopic unsolvated polymorphs were identified, and investigations of these phases were required to identify the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f2d8a3fafae1a5388038c93f61a95a
https://doi.org/10.1021/acs.oprd.8b00253
https://doi.org/10.1021/acs.oprd.8b00253
Publikováno v:
ACS Applied Materials & Interfaces. 10:10480-10489
Nanosizing is rapidly emerging as an alternative approach to enhance solubility and thus the bioavailability of poorly aqueous soluble active pharmaceutical ingredients (APIs). Although numerous techniques have been developed to perform nanosizing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fad78cc8b1582dbcf5703758df27245
https://doi.org/10.1021/acsami.8b01074
https://doi.org/10.1021/acsami.8b01074
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 12, Pp 1714-1717 (2016)
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications
A new co-crystal of piroxicam and gentisic acid has been characterized, in which the ratio of piroxicam (one neutral molecule and one zwitterion) to gentisic acid is 2:1.
A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-
A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef77bde57b8f92f13081486c402b17b0
http://scripts.iucr.org/cgi-bin/paper?S2056989016017321
http://scripts.iucr.org/cgi-bin/paper?S2056989016017321
Autor:
Aristotle E. Economou, Geoff G. Z. Zhang, Elizabeth M. Horstman, Yuchuan Gong, Theodore Papadopoulos, Paul J. A. Kenis, Sachit Goyal
Publikováno v:
RSC Advances. 6:13286-13296
We describe a microfluidic platform with enhanced solvent compatibility to screen solid forms of pharmaceutical parent compounds including salts, cocrystals, and their crystal forms via controlled solvent evaporation and antisolvent addition techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b736724458ddcbc7cd05dc811dc8af0
https://doi.org/10.1039/c5ra26426j
https://doi.org/10.1039/c5ra26426j
Autor:
Yuchuan Gong, Geoff G. Z. Zhang, Garam Lee, Paul J. A. Kenis, Elizabeth M. Horstman, Sachit Goyal, Ashtamurthy S. Pawate
Publikováno v:
Crystal Growth & Design. 15:1201-1209
We describe a microfluidic approach to optimize crystallization of active pharmaceutical ingredients (APIs) and their solid forms (cocrystals) via crystal seeding. Subsequent on-chip X-ray diffraction is used to verify the crystal from. The microflui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1118b9fb56891f871ab9f4b3851da0d
https://doi.org/10.1021/cg5016065
https://doi.org/10.1021/cg5016065
Autor:
Jeffery A. Bertke, Elizabeth M. Horstman, Yuchuan Gong, E. H. Kim, Geoff G. Z. Zhang, L. C. Gonzalez, Paul J. A. Kenis
Publikováno v:
CrystEngComm. 17:5299-5306
A cocrystal of piroxicam (PRX) and 2,5-dihydroxybenzoic acid (HBA), PRX–HBA, and an acetone (ACT) solvate of the cocrystal, PRX–HBA–ACT, were crystallized on a microfluidic platform via solvent evaporation. The inclusion of ACT was found serend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f33667013b9c6e9901070b5ea48fcc37
https://doi.org/10.1039/c5ce00355e
https://doi.org/10.1039/c5ce00355e
Autor:
Phillip Rzeczycki, Gus R. Rosania, Elizabeth M. Horstman, Paul J. A. Kenis, Rahul K. Keswani, Vernon LaLone, Benjamin A. Frey, Jeffery A. Bertke
Supramolecular crystalline assembly constitutes a rational approach to bioengineer intracellular structures. Here, biocrystals of clofazimine (CFZ) that form in vivo within macrophages were measured to have marked curvature. Isolated crystals, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d5307aae0be659181482cb870571fb
https://europepmc.org/articles/PMC5514847/
https://europepmc.org/articles/PMC5514847/
Publikováno v:
Macromolecules. 46:7363-7377
With the goal of improving the moisture resistance of thermosetting polyimides, a thermally stable, polyhedral oligomeric silsesquioxane (POSS) dianiline, which features an aromatic periphery, was co-oligomerized with 4,4 (hexafluoroisopropylidene)di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2a4b5f5ba6d0ffa8a8583d110944726
https://doi.org/10.1021/ma401347q
https://doi.org/10.1021/ma401347q