A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

Autor: Elizabeth M. Haynes, Tyler K. Ulland, Kevin W. Eliceiri

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Rodents have been the dominant animal models in neurobiology and neurological disease research over the past 60 years. The prevalent use of rats and mice in neuroscience research has been driven by several key attributes including their organ physiol

Externí odkaz: https://doaj.org/article/98a749ec7ed1480c9907e323d38f639b

KLC4 shapes axon arbors during development and mediates adult behavior

Autor: Elizabeth M. Haynes, Korri H. Burnett, Jiaye He, Marcel Jean-Pierre, Martin Jarzyna, Kevin W. Eliceiri, Jan Huisken, Mary C. Halloran

Development of elaborate and polarized neuronal morphology requires precisely regulated transport of cellular cargos by motor proteins such as kinesin-1. Kinesin-1 has numerous cellular cargos which must be delivered to unique neuronal compartments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b6f3204ab13fe4341664aebb1dc769
https://doi.org/10.1101/2021.09.26.461872

Lamellipodia are crucial for haptotactic sensing and response

Autor: James G. Alb, Brian Kuhlman, Alicia C. Tagliatela, Daniel J. Marston, Jason M. Haugh, Maddy Parsons, Irina P. Lebedeva, James E. Bear, Seth P. Zimmerman, Jeremy D. Rotty, Elizabeth M. Haynes, Sreeja B. Asokan, Samantha J. King, Devon R. Blake, Norman E. Sharpless, Heath E. Johnson

Publikováno v: King, S J, Asokan, S B, Haynes, E M, Zimmerman, S P, Rotty, J D, Alb, J G, Tagliatela, A, Blake, D R, Lebedeva, I P, Marston, D, Johnson, H E, Parsons, M, Sharpless, N E, Kuhlman, B, Haugh, J M & Bear, J E 2016, ' Lamellipodia are crucial for haptotactic sensing and response ', Journal of Cell Science, vol. 129, no. 12, pp. 2329-2342 . https://doi.org/10.1242/jcs.184507

Haptotaxis is the process by which cells respond to gradients of substrate-bound cues, such as extracellular matrix proteins (ECM); however, the cellular mechanism of this response remains poorly understood and has mainly been studied by comparing ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8536acd15d89018a7d05f98f9ec43a
https://kclpure.kcl.ac.uk/en/publications/82b919ff-3fea-4ece-8e9f-e334493cc508

Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling

Autor: Ian J. Davis, Albert S. Baldwin, James E. Bear, Sreeja B. Asokan, Jeremy M. Simon, Elizabeth M. Haynes, Gary L. Johnson, Norman E. Sharpless, Congying Wu

Publikováno v: The Journal of Cell Biology

A decrease in Arp2/3 levels results in an NF-κB–dependent increase in the expression of several secreted factors, resulting in nonautonomous effects on chemotaxis.
Arp2/3-branched actin is critical for cytoskeletal dynamics and cell migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b67afb8e9ccfeda727500688aab26a
https://pubmed.ncbi.nlm.nih.gov/24344184

Profilin-1 Serves as a Gatekeeper for Actin Assembly by Arp2/3-Dependent and -Independent Pathways

Autor: James E. Bear, Cristian Suarez, Congying Wu, Jason M. Haugh, David R. Kovar, Jonathan D. Winkelman, Jeremy D. Rotty, Elizabeth M. Haynes, Heath E. Johnson

Publikováno v: Developmental Cell. (1):54-67

Summary Cells contain multiple F-actin assembly pathways, including the Arp2/3 complex, formins, and Ena/VASP, which have largely been analyzed separately. They collectively generate the bulk of F-actin from a common pool of G-actin; however, the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e75a09e6ff536b6b4e0146b879d09b