Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elizabeth M. H. Tank"'
Autor:
Eric Bareke, Ze'ev Melamed, Laurie Destroimaisons, Lorne Zinman, Geneviève Di Tomasso, Elizabeth M. H. Tank, Martine Tétreault, Pascale Legault, Anaïs Aulas, Jade-Emmanuelle Deshaies, Sami J. Barmada, Shangxi Xiao, J. Alex Parker, Janice Robertson, Hana Fakim, Christine Vande Velde, Hadjara Sidibé, Paul M. McKeever, Nicolás B. Gómez, Yousra Khalfallah
Publikováno v:
Brain
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a2a74325fd31df4145b13e88f6ded
http://europepmc.org/articles/PMC8677511
http://europepmc.org/articles/PMC8677511
Autor:
Sei-Kyoung Park, Joo Y Hong, Fatih Arslan, Vydehi Kanneganti, Basant Patel, Alex Tietsort, Elizabeth M H Tank, Xingli Li, Sami J Barmada, Susan W Liebman
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006805 (2017)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dep
Externí odkaz:
https://doaj.org/article/c28ff73ebc9b458c8c669f2f26ffcbc2
Autor:
Michael Ostrovsky, Amir Dori, Romana Weissova, Yarden Opatowsky, Roy Maimon, Sami J. Barmada, Eran Perlson, Gayster Alexandra, Elizabeth M. H. Tank, Topaz Altman, Natalia Shelestovich, Martin Balastik, Ariel Ionescu, Tal Gradus Pery, Lior Ankol
Publikováno v:
The EMBO Journal
Amyotrophic lateral sclerosis (ALS) is a fatal non‐cell‐autonomous neurodegenerative disease characterized by the loss of motor neurons (MNs). Mutations in CRMP4 are associated with ALS in patients, and elevated levels of CRMP4 are suggested to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1032758a11a26b7706bca88c678ab41
https://doi.org/10.15252/embj.2020107586
https://doi.org/10.15252/embj.2020107586
Autor:
Jason P. Chua, Jennifer M. Colón-Mercado, Elizabeth M. H. Tank, Lois S. Weisman, Sami J. Barmada, Mats Ljungman, Michelle T. Paulsen, Erin S. Kim, Karan Bedi, Michael E. Ward
Publikováno v:
SSRN Electronic Journal.
Autophagy is a conserved, multi-step process of capturing proteolytic cargo in autophagosomes for lysosome degradation. The capacity to remove toxic proteins that accumulate in neurodegenerative disorders attests to the disease-modifying potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d95004a97a5c587b3d2771ed5fd8b9
https://doi.org/10.2139/ssrn.3892424
https://doi.org/10.2139/ssrn.3892424
Autor:
Yousra Khalfallah, Janice Robertson, Lorne Zinman, Nicolás B. Gómez, G. Di Tomasso, Elizabeth M. H. Tank, Laurie Destroismaisons, Shangxi Xiao, Paul M. McKeever, C. Vande Velde, Z. Melamed, Sami J. Barmada, Martine Tétreault, Anaïs Aulas, Pascale Legault, Eric Bareke, Hadjara Sidibé, J. A. Parker, Jade-Emmanuelle Deshaies
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06a91b9e2f40672fe5ec256cb9016e6
https://doi.org/10.1101/2020.09.15.298455
https://doi.org/10.1101/2020.09.15.298455
Publikováno v:
Genetics. 210:999-1009
The widely conserved heat-shock response, regulated by heat-shock transcription factors, is not only essential for cellular stress resistance and adult longevity, but also for proper development. However, the genetic mechanisms by which heat-shock tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b30ee16ff8ed6b59d027e1d026f9f22
https://doi.org/10.1534/genetics.118.301533
https://doi.org/10.1534/genetics.118.301533
Autor:
Mats Ljungman, Nathaniel Safren, Claudia Figueroa-Romero, Elizabeth M. H. Tank, Lucy M. Hinder, Karan Bedi, S. Thumma, Hilary C. Archbold, Crystal Pacut, Xingli Li, Michelle T. Paulsen, Sami J. Barmada, Junguk Hur, Kaitlin Weskamp, Ximena Paez-Colasante, Eva L. Feldman, Kai Guo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein TDP-43. TDP-43 regulates RNA homeostasis, but it remains unclear whether RNA stability is affected in these di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca4247560fce124f411c68973460916
https://doaj.org/article/a184e2bde9db4d10910de0c58efe84b6
https://doaj.org/article/a184e2bde9db4d10910de0c58efe84b6
Autor:
Elizabeth M H Tank, Heather L True
Publikováno v:
PLoS Genetics, Vol 5, Iss 2, p e1000382 (2009)
Protein homeostasis is critical for cellular survival and its dysregulation has been implicated in Alzheimer's disease (AD) and other neurodegenerative disorders. Despite the growing appreciation of the pathogenic mechanisms involved in familial form
Externí odkaz:
https://doaj.org/article/a6b043ebdf764326ad32144d259cdf8d
Autor:
Yarden Opatowsky, Lior Ankol, Martin Balastik, Elizabeth M. H. Tank, Sami J. Barmada, Romana Weissova, Roy Maimon, Eran Perlson, Tal Gradus Pery
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with selective dysfunction; it causes the death of motor neurons (MNs). In spite of some progress, currently no effective treatment is available for ALS. Before such treatment c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494cb0718bcf3538c27080593a071985
https://doi.org/10.1101/774737
https://doi.org/10.1101/774737
Autor:
Andrea Serio, Jemeen Sreedharan, Elizabeth M. H. Tank, Jonathon P McBride, Ziqiang Lin, Kaitlin Weskamp, Carmen Moreno Gonzalez, Nicolás B. Gómez, Sami J. Barmada, Matthew White, Roberto Miguez
Publikováno v:
J Clin Invest
Weskamp, K, Tank, E M, Miguez, R, McBride, J P, Gómez, N B, White, M, Lin, Z, Moreno Gonzalez, C, Serio, A, Sreedharan, J & Barmada, S J 2020, ' Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS ', Journal of Clinical Investigation, vol. 130, no. 3, pp. 1139-1155 . https://doi.org/10.1172/JCI130988
Weskamp, K, Tank, E M, Miguez, R, McBride, J P, Gómez, N B, White, M, Lin, Z, Moreno Gonzalez, C, Serio, A, Sreedharan, J & Barmada, S J 2020, ' Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS ', Journal of Clinical Investigation, vol. 130, no. 3, pp. 1139-1155 . https://doi.org/10.1172/JCI130988
Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly-conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship between these phenomena remains poorly defined. Here, we showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d701d1a3c042de226b9bbdc3b705021e
https://pubmed.ncbi.nlm.nih.gov/31714900
https://pubmed.ncbi.nlm.nih.gov/31714900