Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Elizabeth M. C. Fisher"'
Autor:
Elisa M. Crombie, Andrea J. Korecki, Karen Cleverley, Bethany A. Adair, Thomas J. Cunningham, Weaverly Colleen Lee, Tess C. Lengyell, Cheryl Maduro, Victor Mo, Liam M. Slade, Ines Zouhair, Elizabeth M. C. Fisher, Elizabeth M. Simpson
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/9121673d743d4e96a21019e14ea29d93
Autor:
Tara Canonica, Emma J. Kidd, Dorota Gibbins, Eva Lana-Elola, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Mark Good
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
BackgroundTrisomy of human chromosome 21 (Hsa21) results in a constellation of features known as Down syndrome (DS), the most common genetic form of intellectual disability. Hsa21 is orthologous to three regions in the mouse genome on mouse chromosom
Externí odkaz:
https://doaj.org/article/b395bf2008984e8eba2831c22e885ced
Autor:
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome
Externí odkaz:
https://doaj.org/article/fdd398815b864621914e2872780af98c
Autor:
Zeinab Ali, Juan M. Godoy-Corchuelo, Aurea B. Martins-Bach, Irene Garcia-Toledo, Luis C. Fernández-Beltrán, Remya R. Nair, Shoshana Spring, Brian J. Nieman, Irene Jimenez-Coca, Rasneer S. Bains, Hamish Forrest, Jason P. Lerch, Karla L. Miller, Elizabeth M. C. Fisher, Thomas J. Cunningham, Silvia Corrochano
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/3f0a2c5de56a43eca3efee6113651e7a
Autor:
Kourtney Sloan, Jared Thomas, Matthew Blackwell, Deanna Voisard, Eva Lana-Elola, Sheona Watson-Scales, Daniel L. Roper, Joseph M. Wallace, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/3bbbbb9016c543a4b1f805a022884fdf
Autor:
Maria Giovanna Garone, Nicol Birsa, Maria Rosito, Federico Salaris, Michela Mochi, Valeria de Turris, Remya R. Nair, Thomas J. Cunningham, Elizabeth M. C. Fisher, Mariangela Morlando, Pietro Fratta, Alessandro Rosa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results
Externí odkaz:
https://doaj.org/article/4355909082b145b69e7ada11d6280eeb
Autor:
Jacinta I. Kalisch-Smith, Nikita Ved, Dorota Szumska, Jacob Munro, Michael Troup, Shelley E. Harris, Helena Rodriguez-Caro, Aimée Jacquemot, Jack J. Miller, Eleanor M. Stuart, Magda Wolna, Emily Hardman, Fabrice Prin, Eva Lana-Elola, Rifdat Aoidi, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Timothy J. Mohun, Samira Lakhal-Littleton, Sarah De Val, Eleni Giannoulatou, Duncan B. Sparrow
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.
Externí odkaz:
https://doaj.org/article/151683b89d484445a2fc425e4f26bd68
Autor:
Alan Mejia Maza, Seth Jarvis, Weaverly Colleen Lee, Thomas J. Cunningham, Giampietro Schiavo, Maria Secrier, Pietro Fratta, James N. Sleigh, Elizabeth M. C. Fisher, Carole H. Sudre
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The neuromuscular junction (NMJ) is the peripheral synapse formed between a motor neuron axon terminal and a muscle fibre. NMJs are thought to be the primary site of peripheral pathology in many neuromuscular diseases, but innervation/denerv
Externí odkaz:
https://doaj.org/article/3ff0e26ea9ca4cddb08257a5dd74ce5e
Autor:
Justin L. Tosh, Elena R. Rhymes, Paige Mumford, Heather T. Whittaker, Laura J. Pulford, Sue J. Noy, Karen Cleverley, LonDownS Consortium, Matthew C. Walker, Victor L. J. Tybulewicz, Rob C. Wykes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (
Externí odkaz:
https://doaj.org/article/976af835ad394de686b40b465f483f68
Autor:
Yichao Yu, Christopher Payne, Nephtali Marina, Alla Korsak, Paul Southern, Ana García‐Prieto, Isabel N. Christie, Rebecca R. Baker, Elizabeth M. C. Fisher, Jack A. Wells, Tammy L. Kalber, Quentin A. Pankhurst, Alexander V. Gourine, Mark F. Lythgoe
Publikováno v:
Advanced Science, Vol 9, Iss 6, Pp n/a-n/a (2022)
Abstract Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing
Externí odkaz:
https://doaj.org/article/3d7a471dc06340348c33afdea1613ef6