A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Autor: Ellis Patrick, Marta Olah, Mariko Taga, Hans-Ulrich Klein, Jishu Xu, Charles C. White, Daniel Felsky, Sonal Agrawal, Chris Gaiteri, Lori B. Chibnik, Sara Mostafavi, Julie A. Schneider, David A. Bennett, Elizabeth M. Bradshaw, Philip L. De Jager

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five mod

Externí odkaz: https://doaj.org/article/e82600beb2694bc492f222157dea85d1

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Autor: Marta Olah, Vilas Menon, Naomi Habib, Mariko F. Taga, Yiyi Ma, Christina J. Yung, Maria Cimpean, Anthony Khairallah, Guillermo Coronas-Samano, Roman Sankowski, Dominic Grün, Alexandra A. Kroshilina, Danielle Dionne, Rani A. Sarkis, Garth R. Cosgrove, Jeffrey Helgager, Jeffrey A. Golden, Page B. Pennell, Marco Prinz, Jean Paul G. Vonsattel, Andrew F. Teich, Julie A. Schneider, David A. Bennett, Aviv Regev, Wassim Elyaman, Elizabeth M. Bradshaw, Philip L. De Jager

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia

Externí odkaz: https://doaj.org/article/70f5aedb5f20425e97be8410947e4a81

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

Autor: Daniel Felsky, Tina Roostaei, Kwangsik Nho, Shannon L. Risacher, Elizabeth M. Bradshaw, Vlad Petyuk, Julie A. Schneider, Andrew Saykin, David A. Bennett, Philip L. De Jager

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis

Externí odkaz: https://doaj.org/article/5c2b0cd3de2c44ac9e972835b9851021

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Autor: Ahmed T. Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M. Bradshaw, Samia J. Khoury, Wassim Elyaman

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mou

Externí odkaz: https://doaj.org/article/2bd631802f2e4fff88549ccea12edba1

APOE and immunity:Research highlights

Autor: Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Piña‐Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia TCW, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C. Carrillo

Publikováno v: Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G M, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity : Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
Alzheimer's and dementia 19(6), 2677-2696 (2023). doi:10.1002/alz.13020
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity: Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020

INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d9ff92093ab0b6d772041ff569c18f
https://research.vumc.nl/en/publications/823b40ac-c075-4456-8a2d-bdf139906d29