Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Autor: Andrea Strakova, Thomas J. Nicholls, Adrian Baez-Ortega, Máire Ní Leathlobhair, Alexander T. Sampson, Katherine Hughes, Isobelle A. G. Bolton, Kevin Gori, Jinhong Wang, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Clara L. Arnold, Leontine Bansse-Issa, Thinlay N. Bhutia, Jocelyn L. Bisson, Kelli Blank, Cristóbal Briceño, Artemio Castillo Domracheva, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Eric Davis, Karina F. de Castro, Andrigo B. De Nardi, Anna P. de Vos, Laura Delgadillo Keenan, Edward M. Donelan, Adela R. Espinoza Huerta, Ibikunle A. Faramade, Mohammed Fazil, Eleni Fotopoulou, Skye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Pagona G. Gouletsou, Rodrigo F. Häfelin Manrique, Joaquim J. G. P. Henriques, Rodrigo S. Horta, Natalia Ignatenko, Yaghouba Kane, Cathy King, Debbie Koenig, Ada Krupa, Steven J. Kruzeniski, Marta Lanza-Perea, Mihran Lazyan, Adriana M. Lopez Quintana, Thibault Losfelt, Gabriele Marino, Simón Martínez Castañeda, Mayra F. Martínez-López, Bedan M. Masuruli, Michael Meyer, Edward J. Migneco, Berna Nakanwagi, Karter B. Neal, Winifred Neunzig, Sally J. Nixon, Antonio Ortega-Pacheco, Francisco Pedraza-Ordoñez, Maria C. Peleteiro, Katherine Polak, Ruth J. Pye, Juan C. Ramirez-Ante, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Alan G. Sherlock, Audrey E. Steenland-Smit, Alla Svitich, Lester J. Tapia Martínez, Ismail Thoya Ngoka, Cristian G. Torres, Elizabeth M. Tudor, Mirjam G. van der Wel, Bogdan A. Vițălaru, Sevil A. Vural, Oliver Walkinton, Alvaro S. Wehrle-Martinez, Sophie A. E. Widdowson, Irina Zvarich, Patrick F. Chinnery, Maria Falkenberg, Claes M. Gustafsson, Elizabeth P. Murchison

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer a

Externí odkaz: https://doaj.org/article/cb9d1b65978f4b9aba741090656d7d49

Implementing the Flipped Classroom in a Veterinary Pre-clinical Science Course: Student Engagement, Performance, and Satisfaction

Autor: Laura M. Dooley, Elizabeth M Tudor, Elise Boller, Sarah Frankland

Publikováno v: Journal of Veterinary Medical Education. 45:195-203

There has been a recent move toward active learning pedagogies in veterinary education, with increasing use of a blended approach that incorporates both online resources and live classroom sessions. In this study, an established veterinary pre-clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef247619d1abf77fc624598c9250f653
https://doi.org/10.3138/jvme.1116-173r

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Autor: Ludmil B. Alexandrov, Janice L Allen, Maximilian R Stammnitz, Adrian Baez-Ortega, Ismail Thoya Ngoka, Yaghouba Kane, Katherine Polak, Debbie Koenig, Gabriele Marino, Inigo Martincorena, Berna Nakanwagi, Andrigo Barboza De Nardi, Joaquim Henriques, Mayra F Martínez-López, Artemio Castillo Domracheva, Cathy King, Thibault Losfelt, Kevin Gori, Young Mi Kwon, Ada Krupa, John F Reece, Antonio Ortega-Pacheco, Natalia Ignatenko, Alvaro S Wehrle-Martinez, Pagona G. Gouletsou, Sally J Nixon, Bogdan A. Viţălaru, Laura Delgadillo Keenan, Elizabeth M Tudor, Audrey E Steenland-Smit, Hugh R Cran, Sevil Atalay Vural, Marta Lanza-Perea, Leontine Bansse-Issa, Michael R. Stratton, Edward J. Migneco, Maria C. Peleteiro, Karina F de Castro, Michael C. Meyer, Eric Davis, Sheila K Schmeling, Adriana M Lopez Quintana, Elizabeth P. Murchison, Simón Martínez Castañeda, Olga Shamanova, Rodrigo dos Santos Horta, Jinhong Wang, Mihran Lazyan, Fanny Gallardo-Arrieta, Skye N Fruean, Karter B. Neal, Anna P de Vos, Jocelyn L Bisson, Alan G. Sherlock, Sophie A.E. Widdowson, Olga Glebova, Lester J. Tapia Martínez, Mohammed Fazil, Steven J. Kruzeniski, Cristian G. Torres, Oliver Walkinton, Ibikunle A Faramade, Winifred Neunzig, Jose Rojas Gutierrez, Adela R. Espinoza Huerta, Mirjam G van der Wel, Haleema Sadia, Edward M Donelan, Alla Svitich, Rodrigo F Häfelin Manrique, Thinlay N Bhutia, Eleni Fotopoulou, Karen M Allum, Francisco Pedraza-Ordoñez, Cristóbal Briceño, Ruth J. Pye, Máire Ní Leathlobhair, Jane T Crawford, Andrea Strakova, Anne M Corrigan

Publikováno v: Baez-Ortega, A, Gori, K, Strakova, A, Allen, J L, Allum, K M, Bansse-Issa, L, Bhutia, T N, Bisson, J L, Briceño, C, Castillo Domracheva, A, Corrigan, A M, Cran, H R, Crawford, J T, Davis, E, de Castro, K F, B de Nardi, A, de Vos, A P, Delgadillo Keenan, L, Donelan, E M, Espinoza Huerta, A R, Faramade, I A, Fazil, M, Fotopoulou, E, Fruean, S N, Gallardo-Arrieta, F, Glebova, O, Gouletsou, P G, Häfelin Manrique, R F, Henriques, J J G P, Horta, R S, Ignatenko, N, Kane, Y, King, C, Koenig, D, Krupa, A, Kruzeniski, S J, Kwon, Y-M, Lanza-Perea, M, Lazyan, M, Lopez Quintana, A M, Losfelt, T, Marino, G, Martínez Castañeda, S, Martínez-López, M F, Meyer, M, Migneco, E J, Nakanwagi, B, Neal, K B, Neunzig, W, Ní Leathlobhair, M, Nixon, S J, Ortega-Pacheco, A, Pedraza-Ordoñez, F, Peleteiro, M C, Polak, K, Pye, R J, Reece, J F, Rojas Gutierrez, J, Sadia, H, Schmeling, S K, Shamanova, O, Sherlock, A G, Stammnitz, M, Steenland-Smit, A E, Svitich, A, Tapia Martínez, L J, Thoya Ngoka, I, Torres, C G, Tudor, E M, van der Wel, M G, Viţălaru, B A, Vural, S A, Walkinton, O, Wang, J, Wehrle-Martinez, A S, Widdowson, S A E, Stratton, M R, Alexandrov, L B, Martincorena, I & Murchison, E P 2019, ' Somatic evolution and global expansion of an ancient transmissible cancer lineage ', Science, vol. 365, no. 6452 . https://doi.org/10.1126/science.aau9923
Science (New York, N.Y.)
Science
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2019-10-06T15:53:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-02 GPD Charitable Trust Leverhulme Trust The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a8d470dc0d731744f9f15700e58704
https://hdl.handle.net/20.500.11820/f34b369d-63dd-4dc1-8101-e952ba9a35e9

Plasma HMGB ‐1 and Nucleosome Concentrations in Horses with Colic and Healthy Horses

Autor: G. Forbes, Jenni Bauquier, Simon R. Bailey, L. Nath, Elizabeth M Tudor

Publikováno v: Journal of Veterinary Internal Medicine

Background Acute gastrointestinal disease occurs commonly in horses. Novel biomarkers might improve the understanding of SIRS and aid diagnosis and determination of prognosis. Hypotheses Increased plasma concentrations of the biomarkers HMGB-1 and nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c0fbe7d31d84f1b3815e1778479751
https://doi.org/10.1111/jvim.13811

A controlled randomized clinical trial to assess postoperative analgesia after thiopental-isoflurane anaesthesia or total intravenous anaesthesia with alfaxalone in dogs

Autor: Elizabeth M Tudor, Ted Whittem, Paula M Bennell

Publikováno v: Journal of veterinary pharmacology and therapeutics. 42(3)

Alfaxalone, a synthetic neuroactive steroid, has been attributed with properties including sedation, anaesthesia and analgesia. The clinical relevance of any analgesic properties of alfaxalone has not been demonstrated. This study was a prospective,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1680737cdbf2e1294ddca39291b61e5
https://pubmed.ncbi.nlm.nih.gov/30666663