Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Elizabeth M Rosethorne"'
Autor:
Anke Bill, Elizabeth M Rosethorne, Toby C Kent, Lindsay Fawcett, Lynn Burchell, Michiel T van Diepen, Anthony Marelli, Sergey Batalov, Loren Miraglia, Anthony P Orth, Nicole A Renaud, Steven J Charlton, Martin Gosling, L Alex Gaither, Paul J Groot-Kormelink
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97973 (2014)
The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation. hIP receptor dysfunction has been implicated in numero
Externí odkaz:
https://doaj.org/article/80aa82d5e7004c4f828cf2a96b6d0895
Autor:
Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne, Michelle L. Halls
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and
Externí odkaz:
https://doaj.org/article/5c85396c76d64dc79fc084910f1ff65a
Autor:
Michelle L. Halls, Elizabeth M. Rosethorne, Maxine J. Roberts, Alastair C. Keen, Lauren T. May, Steven J. Charlton, Bonan Liu, Terrance Lam
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789dec86fe33a91a9b182bd928dee627
https://pubmed.ncbi.nlm.nih.gov/33995100
https://pubmed.ncbi.nlm.nih.gov/33995100
Autor:
Mario Rossi, R. A. John Challiss, Colin Molloy, Eyassu Chernet, Sophie J. Bradley, Paulina Valuskova, Lisa M. Broad, Adrian J. Mogg, Karolina Gherbi, Vanessa N. Barth, Elizabeth M. Rosethorne, Andrew B. Tobin, Arthur Christopoulos, Caroline A. Wilson, Lisa Finlayson, Louis Dwomoh, Miriam Scarpa, Rajendra Mistry, Shuzo Sakata, Patrick M. Sexton, Kjell A. Svensson, David A. Sykes
Cholinesterase inhibitors, the current frontline symptomatic treatment for Alzheimer’s disease (AD), are associated with low efficacy and adverse effects. M1 muscarinic acetylcholine receptors (M1 mAChRs) represent a potential alternate therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e98a59cb796f11c7703f6b34d2e88b3
https://strathprints.strath.ac.uk/71527/1/Bradley_etal_NCB_2019_Biased_M1_muscarinic_receptor_mutant_mice_inform.pdf
https://strathprints.strath.ac.uk/71527/1/Bradley_etal_NCB_2019_Biased_M1_muscarinic_receptor_mutant_mice_inform.pdf
Autor:
Rebecca E. Broome, Elizabeth M. Rosethorne, Toby C. Kent, Maxine J. Roberts, Steven J. Charlton
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-13 (2018)
Respiratory Research
Respiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to explore alternative, novel trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4910e2047884d67fdf8788c5df6d979
http://link.springer.com/article/10.1186/s12931-018-0759-2
http://link.springer.com/article/10.1186/s12931-018-0759-2
Publikováno v:
Journal of Experimental Pharmacology
Airway remodeling is a characteristic of many chronic respiratory diseases and occurs when there are significant changes to the architecture of the small and large airways leading to progressive loss of lung function. Some common features include air
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b92657f7c839a4d2319a9effda9c64
https://pubmed.ncbi.nlm.nih.gov/30568517
https://pubmed.ncbi.nlm.nih.gov/30568517
Autor:
Elizabeth M. Rosethorne, Helen Fitch, Stephen Carl Mckeown, Catherine Leblanc, Arndt Meyer, Brian Cox, Steven J. Charlton, Emily Stanley, Christopher D. Howson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2247-2250
By considering published structural information we have designed high throughput biaryl lipophilic acid arrays leveraging facile chemistry to expedite their synthesis. We rapidly identified multiple hits which were of suitable IP agonist potency. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7aec74466fbb91e884f0518a61436
https://doi.org/10.1016/j.bmcl.2014.03.089
https://doi.org/10.1016/j.bmcl.2014.03.089
Autor:
Viral Patel, Jonathan White, Soraya S. Porres, Ben Moulton, Roy Pettipher, Peter Finan, Clive Mccarthy, Steven J. Charlton, Elizabeth M. Rosethorne, Karolina Gherbi
Publikováno v:
Cancer Research. 79:5014-5014
Adenosine is elevated in the tumour microenvironment and plays a critical role in suppressing T cell function through high affinity interaction with the A2a receptor. Genetic deficiency of A2a in mice is associated with enhanced cytotoxic responses a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eff7fdde7c97578edb206b575538cffe
https://doi.org/10.1158/1538-7445.am2019-5014
https://doi.org/10.1158/1538-7445.am2019-5014
Autor:
Steven J. Charlton, Elizabeth M. Rosethorne, Saskia Nijmeijer, Francesco Sirci, C de Graaf, Henry F. Vischer, Sabine Schultes, Rob Leurs, H Engelhardt
Publikováno v:
British Journal of Pharmacology. 170:78-88
Background and Purpose The histamine H4 receptor, originally thought to signal merely through Gαi proteins, has recently been shown to also recruit and signal via β-arrestin2. Following the discovery that the reference antagonist indolecarboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::341a81053d70955cb5443e158fd91c24
https://doi.org/10.1111/bph.12117
https://doi.org/10.1111/bph.12117
Publikováno v:
British journal of pharmacology. 174(3)
Human lung fibroblasts (HLF) express high levels of the LPAHere, we have explored the signalling profiles of a range of LPA analogues in HLF that endogenously express the LPAThese analyses demonstrated that the 16:0, 17:0, 18:2 and C18:1 LPA analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f2a4ad48ca5342cf4567d51320fa932
https://pubmed.ncbi.nlm.nih.gov/27864940
https://pubmed.ncbi.nlm.nih.gov/27864940