Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Elizabeth M Nolan"'
Autor:
Romana R. Gerner, Suzana Hossain, Artur Sargun, Kareem Siada, Grant J. Norton, Tengfei Zheng, Wilma Neumann, Sean-Paul Nuccio, Elizabeth M. Nolan, Manuela Raffatellu
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the gastrointestinal tract and profound alterations to the gut microbiome. Adherent-invasive Escherichia coli (AIEC) is a mucosa-associated pathobiont that coloni
Externí odkaz:
https://doaj.org/article/1b65887a6d9f4da093e24d1064d852d9
Autor:
Cassandra E. Nelson, Weiliang Huang, Emily M. Zygiel, Elizabeth M. Nolan, Maureen A. Kane, Amanda G. Oglesby
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT To combat infections, the mammalian host limits availability of essential transition metals such as iron (Fe), zinc (Zn), and manganese (Mn) in a strategy termed “nutritional immunity.” The innate immune protein calprotectin (CP) contrib
Externí odkaz:
https://doaj.org/article/d41ca8573911442cb600d96d5551750a
Autor:
Chuchu, Guo, Elizabeth M, Nolan
Publikováno v:
Journal of the American Chemical Society. 144(28)
The global crisis of untreatable microbial infections necessitates the design of new antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire. In this study, we repurpose the clinically approved anticancer agent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22f6128acbcbbbacb0e75ee58b5f55dc
https://pubmed.ncbi.nlm.nih.gov/35803281
https://pubmed.ncbi.nlm.nih.gov/35803281
Autor:
Chuchu Guo, Elizabeth M. Nolan
Publikováno v:
Journal of the American Chemical Society. 144:12756-12768
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e54e15fc6016f3e0e3457004dacc7dbd
https://doi.org/10.1021/jacs.2c03324
https://doi.org/10.1021/jacs.2c03324
Publikováno v:
Trends Microbiol
During infection, the mammalian host initiates a metal-withholding response against invading microbial pathogens to inhibit their growth and survival, a process often termed 'nutritional immunity'. The host-defense S100 proteins calprotectin (CP) (S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa28ea22256241b51ac1695c5bc794
https://doi.org/10.1016/j.tim.2021.12.006
https://doi.org/10.1016/j.tim.2021.12.006
Autor:
Elizabeth M. Nolan, Janet J. Y. Peet
Publikováno v:
BioMetals.
Human calprotectin (CP, S100A8/S100A9 oligomer) is an abundant neutrophil protein that contributes to innate immunity by sequestering nutrient metal ions in the extracellular space. This process starves invading microbial pathogens of essential metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff787867604e1bcbf5ddf8755da7ae5
https://doi.org/10.1007/s10534-023-00493-x
https://doi.org/10.1007/s10534-023-00493-x
Publikováno v:
Chemical Science
Chemical science, vol 12, iss 11
Chemical science, vol 12, iss 11
The design and synthesis of narrow-spectrum antibiotics that target a specific bacterial strain, species, or group of species is a promising strategy for treating bacterial infections when the causative agent is known. In this work, we report the syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6fddabc5e3229567cfa68390f790a4
http://europepmc.org/articles/PMC8179508
http://europepmc.org/articles/PMC8179508
Publikováno v:
J Am Chem Soc
Although knowledge of the coordination chemistry and metal-withholding function of the innate immune protein human calprotectin (hCP) has broadened in recent years, understanding of its Ca2+-binding properties in solution remains incomplete. In parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b05cd6391143a32493db5dce81bf29
https://doi.org/10.1021/jacs.9b11950
https://doi.org/10.1021/jacs.9b11950
Publikováno v:
Metallomics
Zinc is an essential transition metal nutrient for bacterial survival and growth but may become toxic when present at elevated levels. The Gram-positive bacterial pathogen Streptococcus pneumoniae is sensitive to zinc poisoning, which results in grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06925202301a0718e59643192fa3d4df
https://doi.org/10.1093/mtomcs/mfac001
https://doi.org/10.1093/mtomcs/mfac001
Publikováno v:
Biochemistry
Iron (Fe) plays important roles in both essential cellular processes and virulence pathways for many bacteria. Consequently, Fe withholding by the human innate immune system is an effective form of defense against bacterial infection. In this Perspec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edc3706bbb84a0085a0266593a4941d
https://pubmed.ncbi.nlm.nih.gov/34739212
https://pubmed.ncbi.nlm.nih.gov/34739212