Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elizabeth M Davies"'
Autor:
Sarah E. Conduit, Elizabeth M. Davies, Alex J. Fulcher, Viola Oorschot, Christina A. Mitchell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment o
Externí odkaz:
https://doaj.org/article/fb8468d7a7d848198f306db1e3a4ec54
Autor:
Elizabeth M. Davies, Rajendra Gurung, Kai Qin Le, Katherine T. T. Roan, Richard P. Harvey, Geraldine M. Mitchell, Quenten Schwarz, Christina A. Mitchell
Publikováno v:
Science Advances. 9
Dynamic positioning of endothelial tip and stalk cells, via the interplay between VEGFR2 and NOTCH signaling, is essential for angiogenesis. VEGFR2 activates PI3K, which phosphorylates PI(4,5)P 2 to PI(3,4,5)P 3 , activating AKT; however, PI3K/AKT do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4ba1a101bfabcab36ceed205fad802
https://doi.org/10.1126/sciadv.add6911
https://doi.org/10.1126/sciadv.add6911
Autor:
Mona Tafreshi, Jyeswei Guan, Rebecca J. Gorrell, Nicole Chew, Yue Xin, Virginie Deswaerte, Manfred Rohde, Roger J. Daly, Richard M. Peek, Brendan J. Jenkins, Elizabeth M. Davies, Terry Kwok
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The Gram-negative bacterium, Helicobacter pylori, causes chronic gastritis, peptic ulcers, and gastric cancer in humans. Although the gastric epithelium is the primary site of H. pylori colonization, H. pylori can gain access to deeper tissues. Concu
Externí odkaz:
https://doaj.org/article/b1a097d42b064ad4bc1909c04fb46664
Publikováno v:
Br J Radiol
Recent trends in medical decision-making have moved from paternalistic doctor-patient relations to shared decision-making. Informed consent is fundamental to this process and to ensuring patients’ ongoing trust in the health-care profession. It can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76e721dc51476744fe0aa10c2962a28
https://doi.org/10.1259/bjr.20210620
https://doi.org/10.1259/bjr.20210620
Autor:
Christina Anne Mitchell, Elizabeth M Davies, Alex J. Fulcher, Viola Oorschot, Sarah E Conduit
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4acc13747ec35a886e0aae15d23ff65
http://europepmc.org/articles/PMC8120242
http://europepmc.org/articles/PMC8120242
Autor:
Kerrie-Ann McMahon, Lakshmi Balasubramaniam, Srikanth Budnar, Saroja Weeratunga, Robert J. Ju, Suzie Verma, Yoke Seng Lee, Brett M. Collins, Benoit Ladoux, Bipul R. Acharya, Rachel Templin, Hiroko Katsuno-Kambe, Vanesa M. Tomatis, Guillermo A. Gomez, Samantha J. Stebhens, Robert G. Parton, Christina Anne Mitchell, Meagan Jane Mcgrath, Elizabeth M Davies, Jessica L. Teo, Ivar Noordstra, Alpha S. Yap
Epithelia are active materials where mechanical tension governs morphogenesis and homeostasis. But how that tension is regulated remains incompletely understood. We now report that caveolae control epithelial tension and show that this is necessary f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96640b55bce6dd1ec3a1b08a0167768d
https://hdl.handle.net/11541.2/143257
https://hdl.handle.net/11541.2/143257
Autor:
Jennifer M Dyson, Absorn Sriratana, Monica N. Koenig, Sharon D. Ricardo, Sandra Hakim, Robin M. Hobbs, Ian M. Smyth, Elizabeth M Davies, Sandra J Feeney, Christina Anne Mitchell, Olga V. Plotnikova
Publikováno v:
Human Molecular Genetics. 25:2295-2313
Polycystic kidney disease (PKD) is a common cause of renal failure with few effective treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates phosphoinositide 3-kinase (PI3K)-generated PI(3,4,5)P3 and is mutated in ciliopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f664b682f0537b256ba2895e14f97a15
https://doi.org/10.1093/hmg/ddw097
https://doi.org/10.1093/hmg/ddw097
Publikováno v:
Advances in biological regulation. 71
Phosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e1a0d6b42a88d38ba89bed7e33dd72
https://pubmed.ncbi.nlm.nih.gov/30503054
https://pubmed.ncbi.nlm.nih.gov/30503054
Autor:
Elizabeth M Davies, Laima Arsala, Gillian Seaton, Clare G Fedele, Parvin Rahman, Christina Anne Mitchell, Megan Victoria Astle
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 58:451-456
Phosphoinositide signaling molecules control cellular growth, proliferation and differentiation, intracellular vesicle trafficking, and cytoskeletal rearrangement. The inositol polyphosphate 5-phosphatase family remove the D-5 position phosphate from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405789f7206520d4f759b6e260d42b9f
https://doi.org/10.1080/15216540600871159
https://doi.org/10.1080/15216540600871159
Autor:
Clare G Fedele, Antonella Papa, Rajendra Gurung, Lauren C. Binge, Parvin Rahman, Daniel T. Ferguson, Catriona McLean, Ryan C. Chai, John T. Price, Paul Timpson, Lisa M Ooms, James R.W. Conway, Frank Koentgen, Jessica L. Vieusseux, Tony Tiganis, Elizabeth M Davies, Christina Anne Mitchell
Publikováno v:
Cancer cell. 28(2)
SummaryMetastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast cancer cell proliferation and regulates migration. To date, none of the inositol polyphos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509752fd86394ce629df98d83ea6e526
https://pubmed.ncbi.nlm.nih.gov/26267528
https://pubmed.ncbi.nlm.nih.gov/26267528