Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Elizabeth M A Hirst"'
Autor:
Darren J Wight, Virginie C Boucherit, Madushi Wanaguru, Efrat Elis, Elizabeth M A Hirst, Wilson Li, Marcelo Ehrlich, Eran Bacharach, Kate N Bishop
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004474 (2014)
The murine leukaemia virus (MLV) gag gene encodes a small protein called p12 that is essential for the early steps of viral replication. The N- and C-terminal regions of p12 are sequentially acting domains, both required for p12 function. Defects in
Externí odkaz:
https://doaj.org/article/9d5f606ea0a5457790c7a55db9679a92
Autor:
Paola Bonfanti, Anna Baulies, Vivian S. W. Li, Nikhil Thapar, P De Coppi, L Meran, Ambrosius P. Snijders, Michael Orford, Anna Kucharska, Riana Gaifulina, Simon Eaton, Elizabeth M. A. Hirst, Geraint M.H. Thomas, Lucy M. Collinson, Isobel Massie, S. Eli, Julia König, Anne Weston, Peter Faull, Alfonso M Tedeschi, Alessandro Filippo Pellegata
Intestinal failure (IF), following extensive anatomical or functional loss of small intestine (SI), has debilitating long-term effects on infants and children with this condition. Priority of care is to increase the child’s length of functional int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8d5f36c66744d609ff9cc3e85598e8
https://doi.org/10.1101/854083
https://doi.org/10.1101/854083
Autor:
Eva-Maria Frickel, Elizabeth M. A. Hirst, Clémence Foltz, Anna Napolitano, Rabia T. Khan, Barbara Clough
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
Interferon gamma (IFNγ) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the destruction of the parasitophorous vacuole (PV). We previously identified TRIM21 as an IFNγ
Autor:
Vivian S. W. Li, Michael Orford, Paolo De Coppi, Nikhil Thapar, Alessandro Filippo Pellegata, Susanna Eli, L Meran, Alfonso M Tedeschi, Simon Eaton, Sara Campinoti, Ambrosius P. Snijders, Riana Gaifulina, Elizabeth M. A. Hirst, Lucinda Tullie, Laura Novellasdemunt, Anna Baulies, Lucy M. Collinson, Anne Weston, Isobel Massie, Julia König, Paola Bonfanti, Nikolaos Angelis, Geraint M.H. Thomas, Anna Kucharska, Peter Faull
Publikováno v:
Nature medicine. 26(10)
Intestinal failure, following extensive anatomical or functional loss of small intestine, has debilitating long-term consequences for children1. The priority of patient care is to increase the length of functional intestine, particularly the jejunum,
Autor:
Serena Lattante, Marcella Zollino, Paolo Niccolò Doronzio, Aleck W.E. Jones, Antonella Spinazzola, Elizabeth M. A. Hirst, Ilaria Dalla Rosa, Romina Durigon, Henry Houlden, Alice L Mitchell, Giuseppe Maragni, Ian J Holt, Andreea Manole, Mara Mennuni
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
The diverse clinical phenotypes of Wolf–Hirschhorn syndrome (WHS) are the result of haploinsufficiency of several genes, one of which, LETM1, encodes a protein of the mitochondrial inner membrane of uncertain function. Here, we show that LETM1 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52359f6c5d9a714302263c2662e1a83
http://hdl.handle.net/10807/134209
http://hdl.handle.net/10807/134209
Autor:
Elizabeth M. A. Hirst, Vicky L. Spivey, Roger S. Buxton, Stephen J. Smerdon, Rachael H. Whalan
Publikováno v:
Fems Microbiology Letters
The ATP-binding cassette transporter Rv1747 is required for the growth of Mycobacterium tuberculosis in mice and in macrophages. Its structure suggests it is an exporter. Rv1747 forms a two-gene operon with pknF coding for the serine/threonine protei
Autor:
Elizabeth M. A. Hirst, Brigitta Stockinger, Stefania Crotta, Matteo Villa, Andreas Wack, Helena Ahlfors, Kevin S. Dingwell, James C. Smith, Manolis Gialitakis
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia function as barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). However, AhR function in these tissues is unknown. Here we show that AhR regulates multiciliogenesis in both murine air
Autor:
Katarina Milutinovic, Elizabeth M. A. Hirst, Chrislaine Withers-Martinez, Michael J. Blackman, Michael Shea, Catherine Suarez, Fiona Hackett, Andrea Ruecker
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: Malaria parasite egress from host erythrocytes requires cysteine protease activity, but the identity of key parasite proteases is unknown. Results: SERA6 is an essential parasite cysteine protease that resides in the parasitophorous vacuo
Autor:
Eleni Bazigou, Holger Apitz, Jana Johansson, Iris Salecker, Ruth H. Palmer, Pei-Ling Chen, Elizabeth M. A. Hirst, Christina E. Lorén
Publikováno v:
Cell. 128:961-975
SummaryAnaplastic lymphoma kinase (Alk) has been proposed to regulate neuronal development based on its expression pattern in vertebrates and invertebrates; however, its function in vivo is unknown. We demonstrate that Alk and its ligand Jelly belly
Autor:
Elizabeth M. A. Hirst, James Briscoe, Martin Cheung, Anita Mynett, Andreas Schedl, Marie-Christine Chaboissier
Publikováno v:
Developmental Cell. 8:179-192
SummaryTrunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroe