Výsledky vyhledávání - "Elizabeth M, Kass"

Akademický článek

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation

Autor: Elizabeth M. Kass, Pei Xin Lim, Hildur R. Helgadottir, Mary Ellen Moynahan, Maria Jasin

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Mutations in homology-directed repair genes likeBRCA2are linked to breast cancer susceptibility. Here the authors generate mice with an inducible DNA break-reporter system and see high levels of homology-directed repair in proliferative mammary tissu

Externí odkaz: https://doaj.org/article/05628ecc62f8432486b6a2626164ba2c

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Akademický článek

Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females

Autor: Elizabeth R. De Oliveira e Silva, Margaret Kong, Zhihua Han, Catherine Starr, Elizabeth M. Kass, Suh-Hang Hank Juo, David Foster, Hayes M. Dansky, Martin Merkel, Katherine Cundey, Eliot A. Brinton, Jan L. Breslow, Jonathan D. Smith

Publikováno v: Journal of Lipid Research, Vol 40, Iss 7, Pp 1211-1221 (1999)

The metabolic and genetic determinants of HDL cholesterol (HDL-C) levels and HDL turnover were studied in 36 normolipidemic female subjects on a whole-food low-fat metabolic diet. Lipid, lipoprotein, and apolipoprotein levels, lipoprotein size, and a

Externí odkaz: https://doaj.org/article/2ceabc52de4d4de38c1a326ec19e00db

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Akademický článek

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

Autor: James A Dowdle, Monika Mehta, Elizabeth M Kass, Bao Q Vuong, Akiko Inagaki, Dieter Egli, Maria Jasin, Scott Keeney

Publikováno v: PLoS Genetics, Vol 9, Iss 11, p e1003945 (2013)

ATP-dependent chromatin remodelers control DNA access for transcription, recombination, and other processes. Acf1 (also known as BAZ1A in mammals) is a defining subunit of the conserved ISWI-family chromatin remodelers ACF and CHRAC, first purified o

Externí odkaz: https://doaj.org/article/aa9fe6b38eb543f08c279486fb1deca4

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ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair

Autor: Elizabeth M. Kass, Mary Ellen Moynahan, Maria Jasin, Jayanta Chaudhuri, Wei-Feng Yen, Chun-Chin Chen, Thomas Ludwig

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(29)

BRCA1 is essential for homology-directed repair (HDR) of DNA double-strand breaks in part through antagonism of the nonhomologous end-joining factor 53BP1. The ATM kinase is involved in various aspects of DNA damage signaling and repair, but how ATM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6093c6640428ac77a44fed0ad522338c
https://pubmed.ncbi.nlm.nih.gov/28659469

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