Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Elizabeth Lekah"'
Autor:
Yuquan Tong, Yeongju Lee, Xiaohui Liu, Jessica L. Childs-Disney, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius, Herbert Waldmann, Matthew D. Disney
Publikováno v:
Nature. 618:169-179
Target occupancy is often insufficient to elicit biological activity, particularly for RNA, compounded by the longstanding challenges surrounding the molecular recognition of RNA structures by small molecules. Here we studied molecular recognition pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddd01fdc061bbc5774956f8b2b5aaea
https://doi.org/10.1038/s41586-023-06091-8
https://doi.org/10.1038/s41586-023-06091-8
Publikováno v:
ACS Chem Biol
Various studies have shown that selective molecular recognition of RNA targets by small molecules in cells, although challenging, is indeed possible. One facile strategy to enhance selectivity and potency is binding two or more sites within an RNA si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12165a5b28f1b57c4a8bbb5e81a56ecc
https://pubmed.ncbi.nlm.nih.gov/34898169
https://pubmed.ncbi.nlm.nih.gov/34898169
Autor:
Alexander Adibekian, Ilyas Yildirim, Daniel Abegg, Jonas Boström, Hafeez S. Haniff, Malin Lemurell, Matthew D. Disney, Elizabeth Lekah, Michael D. Cameron, Gogce Crynen, Kye Won Wang, Laurent Knerr, Xiaohui Liu
Publikováno v:
Nature chemistry
Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58702304fbf35d8ca290ba80c49bf9e4
https://doi.org/10.1038/s41557-020-0514-4
https://doi.org/10.1038/s41557-020-0514-4
Autor:
Bahjat T. Kurd-Misto, Wangke Shi, Chen Wang, Xiaoguang Liu, Dalila Ferrante, Michaeline Hebron, Sanjana Mulki, Elizabeth Lekah, Charbel Moussa
Publikováno v:
Journal of Alzheimer's disease : JAD. 72(2)
Ubiquitin Specific Protease-13 (USP13) is a de-ubiquinating enzyme that regulates protein ubiquitination and clearance. The role of USP13 is largely unknown in neurodegeneration. In this study we aim to demonstrate whether tau accumulation and/or cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da719320afac849aa99bc9e9626b7a3
https://pubmed.ncbi.nlm.nih.gov/31594232
https://pubmed.ncbi.nlm.nih.gov/31594232