Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Elizabeth L. Siegler"'
Autor:
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide C
Externí odkaz:
https://doaj.org/article/9385e305f428439ba7536b1503dee2fa
Autor:
Shuto Negishi, James H. Girsch, Elizabeth L. Siegler, Evandro D. Bezerra, Kotaro Miyao, R. Leo Sakemura
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2024)
Clinical trials of anti-CD19 chimeric antigen receptor T (CART19) cell therapy have shown high overall response rates in patients with relapsed/refractory B-cell malignancies. CART19 cell therapy has been approved by the US Food and Drug Administrati
Externí odkaz:
https://doaj.org/article/57f5450f57a94f5d869f86b22d6a122f
Autor:
Karan Chohan, Olivia Sirpilla, R. Leo Sakemura, Michelle Cox, Mehrdad Hefazi, Truc Huynh, James Girsch, Kendall Schick, Claudia Manriquez Roman, Carli M. Stewart, Kun Yun, Ismail Can, Ekene J. Ogbodo, Long Mai, Brooke Kimball, Stephen M. Ansell, N. Nora Bennani, Patrick B. Johnston, Jonas Paludo, Jose C. Villasboas-Bisneto, Arushi Khurana, Urshila Durani, Yucai Wang, Paul J. Hampel, Allison Rosenthal, Javier Munoz, Eider Moreno, Januario E. Castro, Hemant S. Murthy, Mohamed Kharfan Dabaja, Sameer Parikh, Neil Kay, Yi Lin, Elizabeth L. Siegler, Saad S. Kenderian
Publikováno v:
HemaSphere, Vol 7, p e07303db (2023)
Externí odkaz:
https://doaj.org/article/31c0139a73454618b647bd71cdefdd63
Autor:
Lionel A. Kankeu Fonkoua, Olivia Sirpilla, Reona Sakemura, Elizabeth L. Siegler, Saad S. Kenderian
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 69-77 (2022)
Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable outcomes in individuals with hematological malignancies, but its success has been hindered by barriers intrinsic to the tumor microenvironment (TME), particularly for solid tu
Externí odkaz:
https://doaj.org/article/fdf450aff84b4f6389f187c5b0ff589e
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 625-633 (2021)
Chimeric antigen receptor T (CART) cells are a promising immunotherapy that has induced dramatic anti-tumor responses in certain B cell malignancies. However, CART cell expansion and trafficking are often insufficient to yield long-term remissions, a
Externí odkaz:
https://doaj.org/article/ad7048e061164c59a855b70e5763821c
Publikováno v:
Clinical Hematology International, Vol 2, Iss 4 (2020)
T cells genetically engineered with chimeric antigen receptors (CART) have become a potent class of cancer immunotherapeutics. Numerous clinical trials of CART cells have revealed remarkable remission rates in patients with relapsed or refractory hem
Externí odkaz:
https://doaj.org/article/ac80b00c5bbb4b24b328a80995121ea8
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chimeric antigen receptor T (CART) cell immunotherapy has been remarkably successful in treating certain relapsed/refractory hematological cancers. However, CART cell therapy is also associated with toxicities which present an obstacle to its wider a
Externí odkaz:
https://doaj.org/article/2146c58c88f44275b0a646dd5793f9b8
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Chimeric antigen receptors (CARs) are engineered receptors that mediate T cell activation. CARs are comprised of activating and co-stimulatory intracellular signaling domains derived from endogenous T cells that initiate signaling required f
Externí odkaz:
https://doaj.org/article/db329b258642401dbf1f0e0ad03c32b1
Publikováno v:
Current Hematologic Malignancy Reports. 18:9-18
Autor:
Reona Leo Sakemura, Claudia Manriquez-Roman, Paulina Horvei, Michelle J. Cox, Truc Huynh, James H. Girsch, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Kristina Ilieva-Babinsky, Christian Augsberger, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Elizabeth L. Siegler, Saad S. Kenderian
Publikováno v:
Blood. 140:2362-2364