Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Elizabeth L. Read"'
Publikováno v:
Frontiers in Genetics, Vol 10 (2020)
Single-cell transcriptomics is advancing discovery of the molecular determinants of cell identity, while spurring development of novel data analysis methods. Stochastic mathematical models of gene regulatory networks help unravel the dynamic, molecul
Externí odkaz:
https://doaj.org/article/dfdf45cae83c47b69c85499b17dda3f5
Autor:
Luis Busto-Moner, Julien Morival, Honglei Ren, Arjang Fahim, Zachary Reitz, Timothy L Downing, Elizabeth L Read
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007195 (2020)
DNA methylation is a heritable epigenetic modification that plays an essential role in mammalian development. Genomic methylation patterns are dynamically maintained, with DNA methyltransferases mediating inheritance of methyl marks onto nascent DNA
Externí odkaz:
https://doaj.org/article/3aeeb43d2c62484aa88d0013ba4b891c
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006352 (2019)
In many biological settings, two or more cells come into physical contact to form a cell-cell interface. In some cases, the cell-cell contact must be transient, forming on timescales of seconds. One example is offered by the T cell, an immune cell wh
Externí odkaz:
https://doaj.org/article/3979338afbd84bdf940e3869e6c6a478
Publikováno v:
Journal of the Royal Society, Interface. 19(195)
DNA methylation occurs predominantly on cytosine-phosphate-guanine (CpG) dinucleotides in the mammalian genome, and the methylation landscape is maintained over mitotic cell division. It has been posited that coupling of maintenance methylation activ
Publikováno v:
Biophysical journal, vol 121, iss 9
The activation of Tcells, key players of the immune system, involves local evacuation of phosphatase CD45 from a region of the Tcell's surface, segregating it from the Tcell receptor. What drives this evacuation? In the presence of antigen, what ensu
The activation of T cells, key players of the immune system, involves local evacuation of phosphatase CD45 from a region of the T cell’s surface, segregating it from the T cell receptor. What drives this evacuation? In the presence of antigen, what
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8927e10caddad1020f0ad07ac82eded3
https://doi.org/10.1101/2021.09.29.462451
https://doi.org/10.1101/2021.09.29.462451
DNA methylation occurs predominantly on cytosine-phosphate-guanine (CpG) dinucleotides in the mammalian genome, and the methylation landscape is maintained over mitotic cell division. It has been posited that coupling of methylation activity among ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79dbb178d054b2e8e205a869d706a27
https://doi.org/10.1101/2021.09.28.462223
https://doi.org/10.1101/2021.09.28.462223
Autor:
Luis Busto-Moner, Timothy L. Downing, Zachary L. Reitz, Julien L. P. Morival, Arjang Fahim, Elizabeth L. Read
DNA methylation is a heritable epigenetic modification that plays an essential role in mammalian development. Genomic methylation patterns are dynamically maintained, with DNA methyltransferases mediating inheritance of methyl marks onto nascent DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195520b8cff6ac1d3f5ad20221d15b69
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro, vol 8, iss 9
Macrophages are versatile cells of the immune system that play an important role in both advancing and resolving inflammation. Macrophage activation has been described as a continuum, and different stimuli lead to M1, M2, or mixed phenotypes. In addi
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006336 (2018)
PLoS Computational Biology
PLoS Computational Biology
Stochastic simulation has been a powerful tool for studying the dynamics of gene regulatory networks, particularly in terms of understanding how cell-phenotype stability and fate-transitions are impacted by noisy gene expression. However, gene networ