Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Elizabeth L. Ostler"'
Autor:
Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler, Lorna W. Harries
Publikováno v:
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related p
Externí odkaz:
https://doaj.org/article/717f49a517e94b39be55597aba23e861
Publikováno v:
F1000Research, Vol 6 (2017)
The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been ma
Externí odkaz:
https://doaj.org/article/196510948e2748f48c2d1b335fa6829a
Publikováno v:
Sub-cellular biochemistry. 102
Cellular senescence is a permanent state of growth arrest coupled with profound changes in phenotype that can be triggered by multiple extrinsic or intrinsic stimuli. Senescence is a process-level example of the evolution of ageing mechanisms through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d737e2b32ab871cae37f2f4d07c57a2
https://pubmed.ncbi.nlm.nih.gov/36600134
https://pubmed.ncbi.nlm.nih.gov/36600134
Publikováno v:
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science ISBN: 9783031214097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17166a6a8a72ae298ccf41089ab49de
https://doi.org/10.1007/978-3-031-21410-3_8
https://doi.org/10.1007/978-3-031-21410-3_8
Publikováno v:
Biogerontology. 21:817-826
Resveratrol alters the cytokinetics of mammalian cell populations in a dose dependent manner. Concentrations above 25-50 µM typically trigger growth arrest, senescence and/or apoptosis in multiple different cell types. In contrast, concentrations be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1556656dcca8b7c2fab5e71f35ec1c
https://doi.org/10.1007/s10522-020-09896-6
https://doi.org/10.1007/s10522-020-09896-6
Autor:
J. Charles C. Jeynes, David Melzer, Amy Hooper, Helen R. Dawe, Eva Latorre, Lynne S. Cox, Vishal C. Birar, Richard G. A. Faragher, Elizabeth L. Ostler, Angela Sheerin, Lorna W. Harries
Publikováno v:
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
BMC Cell Biology
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
BMC Cell Biology
BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aceecdf8d4045ea3a0fb1c94c888eb
http://zaguan.unizar.es/record/89885
http://zaguan.unizar.es/record/89885
Publikováno v:
The FASEB Journal. 33:1086-1097
Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age-related dysregulation of expression; they are emergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c2e76037994f7ef2721bc526b4b310
https://doi.org/10.1096/fj.201801154r
https://doi.org/10.1096/fj.201801154r
Publikováno v:
Gerontology. 66(3)
For much of the 20th century the ageing process was thought to be the result of the interplay of many different biological processes, each with relatively small effects on organismal lifespan. However, this model is no longer tenable. Rather it seems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d92127eae874c2e220f4799a6a1784
https://pubmed.ncbi.nlm.nih.gov/31914446
https://pubmed.ncbi.nlm.nih.gov/31914446
Publikováno v:
F1000Research
The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe944340b549392b918decaea484af2a
http://europepmc.org/articles/PMC5531163
http://europepmc.org/articles/PMC5531163
Autor:
Almas Kenessary, Talgat Nurgozhin, Zhaxybay Zhumadilov, Lynne S. Cox, Mark Yeoman, David Glyn Kipling, Elizabeth L. Ostler, Richard G. A. Faragher
Publikováno v:
New Biotechnology. 30:373-377
Population ageing is probably the single most important healthcare challenge the developed and developing world will face in the 21st century. This is because the later part of the human life course is marked by the emergence of a wide spectrum of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e1c97f9a47b3e4e7c04d325515b8b
https://doi.org/10.1016/j.nbt.2012.11.018
https://doi.org/10.1016/j.nbt.2012.11.018