Výsledky vyhledávání - "Elizabeth L. Lipscomb"

Biosynthesis of valine and isoleucine: synthesis and biological activity of (2S)-α-acetolactic acid (2-hydroxy-2-methyl-3-oxobutanoic acid), and (2R)- and (2S)-α-acetohydroxybutyric acid (2-ethyl-2-hydroxy-3-oxobutanoic acid)

Autor: Shimoga R. Prakash, Frank B. Armstrong, David H. G. Crout, Michael B. Mitchell, Elizabeth L. Lipscomb

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1197-1201

Stereoisomers of the two substrates for the enzyme reductoisomerase of the valine-isoleucine pathway of biosynthesis have been synthesised in optically pure form. These compounds are (2S)-α-acetolactate (2-hydroxy-2-methyl-3-oxobutanoate) and (2R)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fe598899ea14065a12c8f892c107213
https://doi.org/10.1039/p19830001197

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Structure–activity studies with the αβ-dihydroxyacid dehydratase of Salmonella typhimurium

Autor: Frank B. Armstrong, P. Morgan, Elizabeth L. Lipscomb, David H. G. Crout

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :691-696

(2RS,3RS)- and (2RS,3SR)-2,3-Dihydroxybutanoic acids, (2R,3R)-2,3-dihydroxy-3-methypentanoic acid, (2RS)-2-ethyl-2,3-dihydroxypentanoic acid, (2RS,3RS)- and (2RS,3SR)-2,3-dihydroxy-3-methylhexanoic acids, and (2RS,3RS)- and (2RS,3SR)-2,3-dihydroxy-3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::310f24961de3a9e4f560a89cbe766674
https://doi.org/10.1039/p19850000691

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Stereochemistry of valine biosynthesis. Configuration of the product of rearrangement of alpha-acetolactate

Autor: Frank B. Armstrong, Elizabeth L. Lipscomb, David H. G. Crout, Charles J. R. Hedgecock

Publikováno v: European journal of biochemistry. 110(2)

When alpha-aceto[1,3,5-13C3]lactate (2-hydroxy-2-methyl-3-oxo[1,3,5-13C3]butanoate) was incubated with a cell-free system prepared from Salmonella typhimurium, the valine produced was labelled in the C-4 pro-S position. This result proves that during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95e53279f6934678843b2b75bad936e
https://pubmed.ncbi.nlm.nih.gov/7002550

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Biosynthesis of L-valine in Salmonella typhimurium: origin of the diastereotopic methyl groups

Autor: Frank B. Armstrong, Charles J. R. Hedgecock, Elizabeth L. Lipscomb, David H. G. Crout

Publikováno v: Journal of the Chemical Society, Chemical Communications. :304

When [1,3,5-13C3]-α-acetolactate {[1,3,5-13C3]-2-hydroxy-2-methyl-3-oxobutanoate}(1′) was incubated with a cell-free system from Salmonella typhimurium, the valine (5′) produced was labelled in the C-4 pro-S position, proving that during the ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3637a41e305b0879a13ce43af42fbc58
https://doi.org/10.1039/c39800000304

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